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IID00219
 UniprotQ8WUM0
ProteinNuclear pore complex protein Nup133
GeneNUP133
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1156
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 67-514 Monomer :
 Evidence X-RAY 1xks A Reference
       Region 1xks A 67-74 disorder
       Region 1xks A 75-162 order
       Region 1xks A 163-169 disorder
       Region 1xks A 170-201 order
       Region 1xks A 202-205 disorder
       Region 1xks A 206-251 order
       Region 1xks A 252-269 disorder
       Region 1xks A 270-477 order
       Region 1xks A 478-514 disorder
Seq 517-1156 Hetero dimer : P57740
 Evidence X-RAY 3i4r B Reference
       Region 3i4r B 517-517 disorder
       Region 3i4r B 518-575 order
       Region 3i4r B 576-595 disorder
       Region 3i4r B 596-630 order
       Region 3i4r B 631-637 disorder
       Region 3i4r B 638-713 order
       Region 3i4r B 714-717 disorder
       Region 3i4r B 718-746 order
       Region 3i4r B 747-774 disorder
       Region 3i4r B 775-907 order
       Region 3i4r B 908-920 disorder
       Region 3i4r B 921-1059 order
       Region 3i4r B 1060-1063 disorder
       Region 3i4r B 1064-1083 order
       Region 3i4r B 1084-1094 disorder
       Region 3i4r B 1095-1105 order
       Region 3i4r B 1106-1118 disorder
       Region 3i4r B 1119-1129 order
       Region 3i4r B 1130-1140 disorder
       Region 3i4r B 1141-1156 order
Seq 934-1156 Hetero dimer : P57740
 Evidence X-RAY 3cqg B Reference
       Region 3cqg B 934-934 disorder
       Region 3cqg B 935-1060 order
       Region 3cqg B 1061-1064 disorder
       Region 3cqg B 1065-1083 order
       Region 3cqg B 1084-1094 disorder
       Region 3cqg B 1095-1105 order
       Region 3cqg B 1106-1118 disorder
       Region 3cqg B 1119-1129 order
       Region 3cqg B 1130-1139 disorder
       Region 3cqg B 1140-1156 order
Seq 935-1156 Hetero dimer : P57740
 Evidence X-RAY 3cqc B Reference
       Region 3cqc B 935-1059 order
       Region 3cqc B 1060-1063 disorder
       Region 3cqc B 1064-1083 order
       Region 3cqc B 1084-1094 disorder
       Region 3cqc B 1095-1105 order
       Region 3cqc B 1106-1118 disorder
       Region 3cqc B 1119-1129 order
       Region 3cqc B 1130-1140 disorder
       Region 3cqc B 1141-1156 order
Seqphosphorylation
    28-28 Phosphothreonine
    489-489 Phosphoserine
    480-480 Phosphoserine
    131-131 Phosphoserine
    72-72 Phosphoserine
    50-50 Phosphoserine
    45-45 Phosphoserine
    41-41 Phosphoserine
    493-493 Phosphoserine
    27-27 Phosphoserine
    15-15 Phosphoserine
    7-7 Phosphoserine
    501-501 Phosphoserine
    755-755 Phosphoserine
    1133-1133 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
    787-787 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-68,163-171,250-268,480-496
Order 69-131,136-162,172-249,269-474,501-589,595-713,718-982,988-1156
ProS 250-268,483-496
AlphaFold
Disorder 1-75,101-101,131-132,134-136,162-168,202-205,248-270,477-517,531-533,545-554,580-594,715-717,752-758,825-827,919-920,1060-1063,1084-1092,1116-1116,1129-1131,1133-1133,1136-1136,1153-1156
Order 76-100,102-130,133-133,137-161,169-201,206-247,271-476,518-530,534-544,555-579,595-714,718-751,759-824,828-918,921-1059,1064-1083,1093-1115,1117-1128,1132-1132,1134-1135,1137-1152
Pfam Hmmer
PF04044 569-1036 1.3e-264
SEG 542-558 ,844-853 ,965-980 ,1052-1069
Function
Function in SwissProt
Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222).