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IID00220
 UniprotQ92585
ProteinMastermind-like protein 1
GeneMAML1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1016
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 13-74
 Evidence CD Reference
       Region 13-74 disorder
Seq 13-74 Hetero trimer : IID00199Complex,IID00380Complex
 Evidence X-RAY 2f8x M Reference
       Region 2f8x M 13-15 disorder
       Region 2f8x M 16-70 order
       Region 2f8x M 71-74 disorder
Seq 13-74 Hetero hexamer : IID00199Complex,IID00380Complex
 Evidence X-RAY 3nbn F Reference
       Region 3nbn F 13-15 disorder
       Region 3nbn F 16-70 order
       Region 3nbn F 71-74 disorder
 Evidence X-RAY 3nbn C Reference
       Region 3nbn C 13-15 disorder
       Region 3nbn C 16-70 order
       Region 3nbn C 71-74 disorder
Seq 13-74 Hetero tetramer : IID00199Complex,IID00380Complex
 Evidence X-RAY 3v79 M Reference
       Region 3v79 M 13-15 disorder
       Region 3v79 M 16-70 order
       Region 3v79 M 71-74 disorder
SeqProS verified 16-70 This region is ordered in the complex with the Ank domain in notch. Hetero hexamer : IID00199Complex,IID00380Complex
       Region 3nbn C 16-70 order
       Region 3nbn F 16-70 order
       Region 13-74 disorder
SeqProS verified 16-70 This region is ordered in the complex with the Ank domain in notch. Hetero tetramer : IID00199Complex,IID00380Complex
       Region 3v79 M 16-70 order
       Region 13-74 disorder
SeqProS verified 16-70 This region is ordered in the complex with the Ank domain in notch. Hetero trimer : IID00199Complex,IID00380Complex
       Region 2f8x M 16-70 order
       Region 13-74 disorder
Seqphosphorylation
    45-45 Phosphoserine
    120-120 Phosphoserine
    303-303 Phosphoserine
    314-314 Phosphoserine
    360-360 Phosphoserine
    1015-1015 Phosphoserine
Seqacetylation
    822-822 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-11,42-990,1013-1016
Order 12-41,991-1012
ProS 1-11,42-66,106-116,125-148,186-193,207-226,238-278,314-317,960-978,984-990,1013-1016
AlphaFold
Disorder 1-16,71-245,261-264,268-268,271-396,408-614,662-990,999-1002,1015-1016
Order 17-70,246-260,265-267,269-270,397-407,615-661,991-998,1003-1014
SEG 21-32 ,77-90 ,413-426 ,526-535 ,622-654 ,801-810 ,907-926
Function
Function in SwissProt
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.