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IID00224
UniprotQ9NQS7
ProteinInner centromere protein
GeneINCENP
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
918
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-47 Hetero trimer : IID00186Complex,IID00215Complex
 Evidence X-RAY 2qfa C Reference
       Region 2qfa C 1-2 disorder
       Region 2qfa C 3-47 order
Seq 47-55 Hetero trimer : Q04826
 Evidence X-RAY 5ieh C Reference
       Region 5ieh C 47-55 order
 Evidence X-RAY 5iek C Reference
       Region 5iek C 47-55 order
Seq 835-903 Hetero dimer : Q96GD4
 Evidence X-RAY 4af3 D Reference
       Region 4af3 D 835-839 disorder
       Region 4af3 D 840-882 order
       Region 4af3 D 883-903 disorder
Seqphosphorylation
    213-213 Phosphothreonine
    199-199 Phosphothreonine
    197-197 Phosphoserine
    195-195 Phosphothreonine
    150-150 Phosphothreonine
    148-148 Phosphoserine
    143-143 Phosphoserine
    119-119 Phosphoserine
    72-72 Phosphoserine
    478-478 Phosphothreonine
    239-239 Phosphothreonine
    263-263 Phosphoserine
    269-269 Phosphoserine
    275-275 Phosphoserine
    292-292 Phosphothreonine
    296-296 Phosphoserine
    306-306 Phosphoserine
    312-312 Phosphoserine
    314-314 Phosphoserine
    330-330 Phosphoserine
    400-400 Phosphoserine
    406-406 Phosphothreonine
    446-446 Phosphoserine
    476-476 Phosphoserine
    219-219 Phosphothreonine
    480-480 Phosphoserine
    510-510 Phosphoserine
    514-514 Phosphoserine
    828-828 Phosphoserine
    831-831 Phosphoserine
    832-832 Phosphothreonine
    892-892 Phosphothreonine; by AURKB and AURKC
    893-893 Phosphoserine; by AURKB and AURKC
    894-894 Phosphoserine; by AURKB and AURKC
    899-899 Phosphoserine
    914-914 Phosphoserine
    214-214 Phosphoserine
 
Prediction
NeProc
Disorder 1-5,43-534,786-836,886-918
Order 6-42,535-785,837-885
ProS 43-57,72-76,121-126,165-181,238-245,252-257,278-288,320-324,353-365,450-455,487-498,516-534,789-836,886-905,910-918
AlphaFold
Disorder 1-9,46-55,60-60,63-170,188-534,758-758,760-760,762-818,822-832,891-918
Order 10-45,56-59,61-62,171-187,535-757,759-759,761-761,819-821,833-890
Pfam Hmmer
PF03941 825-883 2.9e-34
SEG 83-103 ,127-153 ,197-208 ,377-394 ,459-472 ,558-582 ,586-602 ,608-784
Function
Function in SwissProt
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:15316025, PubMed:12925766, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428).