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IID00225
 UniprotQ9UBU9
ProteinNuclear RNA export factor 1
GeneNXF1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
619
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 53-82 Hetero dimer : IID00094Complex
 Evidence X-RAY 2z5k B Reference
       Region 2z5k B 53-67 disorder
       Region 2z5k B 68-79 order
       Region 2z5k B 80-82 disorder
 Evidence X-RAY 2z5m B Reference
       Region 2z5m B 53-69 disorder
       Region 2z5m B 70-79 order
       Region 2z5m B 80-82 disorder
Seq 96-362 Monomer :
 Evidence X-RAY 3rw6 A This region binds to RNA. Reference
       Region 3rw6 A 96-117 disorder
       Region 3rw6 A 118-362 order
 Evidence X-RAY 3rw6 B This region binds to RNA. Reference
       Region 3rw6 B 96-116 disorder
       Region 3rw6 B 117-360 order
       Region 3rw6 B 361-362 disorder
Seq 96-372 Homo dimer :
 Evidence X-RAY 1koh A Reference
       Region 1koh A 96-104 disorder
       Region 1koh A 105-362 order
       Region 1koh A 363-372 disorder
 Evidence X-RAY 1koh B Reference
       Region 1koh B 96-200 disorder
       Region 1koh B 201-367 order
       Region 1koh B 368-372 disorder
 Evidence X-RAY 1koh C Reference
       Region 1koh C 96-103 disorder
       Region 1koh C 104-362 order
       Region 1koh C 363-372 disorder
 Evidence X-RAY 1koh D Reference
       Region 1koh D 96-200 disorder
       Region 1koh D 201-372 order
 Evidence X-RAY 1koo A Reference
       Region 1koo A 96-104 disorder
       Region 1koo A 105-362 order
       Region 1koo A 363-372 disorder
 Evidence X-RAY 1koo B Reference
       Region 1koo B 96-202 disorder
       Region 1koo B 203-367 order
       Region 1koo B 368-372 disorder
 Evidence X-RAY 1koo C Reference
       Region 1koo C 96-100 disorder
       Region 1koo C 101-362 order
       Region 1koo C 363-372 disorder
 Evidence X-RAY 1koo D Reference
       Region 1koo D 96-203 disorder
       Region 1koo D 204-372 order
 Evidence X-RAY 3rw7 A Reference
       Region 3rw7 A 96-117 disorder
       Region 3rw7 A 118-199 order
       Region 3rw7 A 200-202 disorder
       Region 3rw7 A 203-362 order
 Evidence X-RAY 3rw7 B Reference
       Region 3rw7 B 96-202 disorder
       Region 3rw7 B 203-362 order
 Evidence X-RAY 3rw7 C Reference
       Region 3rw7 C 96-116 disorder
       Region 3rw7 C 117-198 order
       Region 3rw7 C 199-202 disorder
       Region 3rw7 C 203-362 order
 Evidence X-RAY 3rw7 D Reference
       Region 3rw7 D 96-203 disorder
       Region 3rw7 D 204-362 order
Seq 96-555 Hetero tetramer : IID00399Complex
 Evidence X-RAY 4wyk A Reference
       Region 4wyk A 96-202 disorder
       Region 4wyk A 203-423 order
       Region 4wyk A 424-426 disorder
       Region 4wyk A 427-549 order
       Region 4wyk A 550-555 disorder
 Evidence X-RAY 4wyk C Reference
       Region 4wyk C 96-201 disorder
       Region 4wyk C 202-424 order
       Region 4wyk C 425-426 disorder
       Region 4wyk C 427-549 order
       Region 4wyk C 550-555 disorder
Seq 102-372 Hetero trimer :
 Evidence X-RAY 1ft8 A Reference
       Region 1ft8 A 102-117 disorder
       Region 1ft8 A 118-199 order
       Region 1ft8 A 200-202 disorder
       Region 1ft8 A 203-362 order
       Region 1ft8 A 363-372 disorder
 Evidence X-RAY 1ft8 B Reference
       Region 1ft8 B 102-202 disorder
       Region 1ft8 B 203-367 order
       Region 1ft8 B 368-372 disorder
 Evidence X-RAY 1ft8 C Reference
       Region 1ft8 C 102-116 disorder
       Region 1ft8 C 117-198 order
       Region 1ft8 C 199-200 disorder
       Region 1ft8 C 201-362 order
       Region 1ft8 C 363-372 disorder
 Evidence X-RAY 1ft8 D Reference
       Region 1ft8 D 102-203 disorder
       Region 1ft8 D 204-365 order
       Region 1ft8 D 366-372 disorder
 Evidence X-RAY 1ft8 E Reference
       Region 1ft8 E 102-118 disorder
       Region 1ft8 E 119-123 order
       Region 1ft8 E 124-130 disorder
       Region 1ft8 E 131-153 order
       Region 1ft8 E 154-159 disorder
       Region 1ft8 E 160-175 order
       Region 1ft8 E 176-372 disorder
Seq 102-372 Homo dimer :
 Evidence X-RAY 1fo1 A Reference
       Region 1fo1 A 102-122 disorder
       Region 1fo1 A 123-143 order
       Region 1fo1 A 144-146 disorder
       Region 1fo1 A 147-159 order
       Region 1fo1 A 160-170 disorder
       Region 1fo1 A 171-191 order
       Region 1fo1 A 192-202 disorder
       Region 1fo1 A 203-362 order
       Region 1fo1 A 363-372 disorder
 Evidence X-RAY 1fo1 B Reference
       Region 1fo1 B 102-202 disorder
       Region 1fo1 B 203-365 order
       Region 1fo1 B 366-372 disorder
Seq 371-619 Hetero dimer : IID00399Complex
 Evidence X-RAY 1jkg B Reference
       Region 1jkg B 371-423 order
       Region 1jkg B 424-429 disorder
       Region 1jkg B 430-555 order
       Region 1jkg B 556-619 disorder
Seq 371-619 Hetero trimer : IID00399Complex
 Evidence X-RAY 1jn5 B Reference
       Region 1jn5 B 371-423 order
       Region 1jn5 B 424-427 disorder
       Region 1jn5 B 428-555 order
       Region 1jn5 B 556-619 disorder
Seq 551-619 Monomer :
 Evidence NMR 1go5 A Reference
       Region 1go5 A 551-619 order
       Region 1go5 A 551-562 disorder
       Region 1go5 A 551-561 high_rmsd
       Region 1go5 A 563-619 order
Seq 561-619 Hetero dimer :
 Evidence X-RAY 1oai A Reference
       Region 1oai A 561-619 order
SeqProS possible 68-79 Nuclear Localization Signal (NLS) Hetero dimer : IID00094Complex
       Region 2z5m B 70-79 order
       Region 2z5k B 68-79 order
SeqProS verified 194-204 This region binds to RNA. :
       Region 3rw6 A 118-362 order
       Region 3rw6 B 117-360 order
       Region 1fo1 A 192-202 disorder
Seqphosphorylation
    9-9 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-115,545-565
Order 116-544,566-619
ProS 1-46,51-102
AlphaFold
Disorder 1-117,198-202,550-562,566-566,577-577,592-592,594-595,597-599,601-601,603-605,608-609,611-611,619-619
Order 118-197,203-549,563-565,567-576,578-591,593-593,596-596,600-600,602-602,606-607,610-610,612-618
Pfam Hmmer
PF02136 386-536 4.5e-16
PF03943 558-619 5.1e-39
SEG 36-51 ,184-194 ,267-280 ,551-565
Function
Function in SwissProt
Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244).