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IID00228
 UniprotQ9Y263
ProteinPhospholipase A-2-activating protein
GenePLAA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
795
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 340-465 Hetero dimer : P0CG48
 Evidence NMR 2k8b B Reference
       Region 2k8b B 386-465 order
       Region 2k8b B 386-389 high_rmsd
       Region 2k8b B 463-465 high_rmsd
 Evidence NMR 2k8c B Reference
       Region 2k8c B 340-392 disorder
       Region 2k8c B 386-465 order
       Region 2k8c B 386-391 high_rmsd
       Region 2k8c B 393-456 order
       Region 2k8c B 457-465 disorder
       Region 2k8c B 465-465 high_rmsd
Seq 386-465 Monomer :
 Evidence NMR 2k89 A Reference
       Region 2k89 A 386-465 order
       Region 2k89 A 386-391 high_rmsd
       Region 2k89 A 460-465 high_rmsd
 Evidence NMR 2k8a A Reference
       Region 2k8a A 386-465 order
       Region 2k8a A 386-391 high_rmsd
       Region 2k8a A 460-465 high_rmsd
Seq 511-795 Hetero tetramer : IID00201Complex
 Evidence X-RAY 3ebb A Reference
       Region 3ebb A 511-530 disorder
       Region 3ebb A 531-795 order
 Evidence X-RAY 3ebb B Reference
       Region 3ebb B 511-530 disorder
       Region 3ebb B 531-717 order
       Region 3ebb B 718-720 disorder
       Region 3ebb B 721-795 order
 Evidence X-RAY 3ebb C Reference
       Region 3ebb C 511-529 disorder
       Region 3ebb C 530-632 order
       Region 3ebb C 633-633 disorder
       Region 3ebb C 634-795 order
 Evidence X-RAY 3ebb D Reference
       Region 3ebb D 511-531 disorder
       Region 3ebb D 532-692 order
       Region 3ebb D 693-693 disorder
       Region 3ebb D 694-716 order
       Region 3ebb D 717-718 disorder
       Region 3ebb D 719-795 order
Seqphosphorylation
    50-50 Phosphoserine
Seqacetylation
    529-529 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-5,324-327,459-529
Order 6-323,328-458,530-582,592-647,653-795
ProS 467-478,491-502,514-521
AlphaFold
Disorder 1-5,51-52,163-163,323-332,334-334,382-395,398-399,409-414,456-530
Order 6-50,53-162,164-322,333-333,335-381,396-397,400-408,415-455,531-795
Pfam Hmmer
PF00400 55-98 1.9e-06
PF00400 102-139 0.00034
PF00400 141-179 6.1e-11
PF00400 181-218 0.00045
PF00400 221-259 5.7e-09
PF08324 533-791 5.6e-112
Function
Function in SwissProt
Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986).