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IID00235
 UniprotP36956
ProteinSterol regulatory element-binding protein 1
GeneSREBF1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1147
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 319-400 Homo tetramer :
 Evidence X-RAY 1am9 D Reference
       Region 1am9 D 319-394 order
       Region 1am9 D 395-400 disorder
 Evidence X-RAY 1am9 C Reference
       Region 1am9 C 319-400 order
 Evidence X-RAY 1am9 B Reference
       Region 1am9 B 319-319 disorder
       Region 1am9 B 320-394 order
       Region 1am9 B 395-400 disorder
 Evidence X-RAY 1am9 A Reference
       Region 1am9 A 319-398 order
       Region 1am9 A 399-400 disorder
Seqphosphorylation
    117-117 Phosphoserine
    457-457 Phosphoserine
    1060-1060 Phosphoserine
    402-402 Phosphoserine; by SIK1
    396-396 Phosphoserine; by AMPK
    337-337 Phosphoserine; by SIK1
    338-338 Phosphoserine; by SIK1
    98-98 Phosphoserine
 
Prediction
NeProc
Disorder 1-20,25-322,402-538,649-652,825-836,846-851,995-1004,1068-1076,1141-1147
Order 21-24,323-401,539-648,653-752,757-824,837-845,856-988,1009-1067,1077-1140
ProS 1-8,14-20,25-49,289-293,301-309,410-415,426-430,461-465,483-538,649-652,825-836,995-999,1068-1076,1141-1147
AlphaFold
Disorder 1-325,397-397,399-480,502-543,649-654,752-754,781-784,820-830,851-868,931-938,959-962,990-1004,1062-1081,1103-1105,1123-1123,1139-1147
Order 326-396,398-398,481-501,544-648,655-751,755-780,785-819,831-850,869-930,939-958,963-989,1005-1061,1082-1102,1106-1122,1124-1138
Pfam Hmmer
PF00010 324-374 2.8e-18
SEG 62-82 ,87-107 ,143-159 ,164-179 ,184-201 ,215-238 ,438-461 ,544-566 ,599-612 ,657-672 ,690-703 ,987-998 ,1062-1075
Function
Function in SwissProt
Sterol regulatory element-binding protein 1:Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity).
Processed sterol regulatory element-binding protein 1:Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed:8402897, PubMed:12177166, PubMed:32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:8402897, PubMed:12177166). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation (PubMed:8402897, PubMed:12177166, PubMed:32322062).
Isoform SREBP-1A
Isoform expressed only in select tissues, which has higher transcriptional activity compared to SREBP-1C (By similarity). Able to stimulate both lipogenic and cholesterogenic gene expression (PubMed:12177166). Has a role in the nutritional regulation of fatty acids and triglycerides in lipogenic organs such as the liver (By similarity). Required for innate immune response in macrophages by regulating lipid metabolism (By similarity).
Isoform SREBP-1C
Predominant isoform expressed in most tissues, which has weaker transcriptional activity compared to isoform SREBP-1A (By similarity). Primarily controls expression of lipogenic gene (PubMed:12177166). Strongly activates global lipid synthesis in rapidly growing cells (By similarity).
Isoform SREBP-1aDelta
The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters.
Isoform SREBP-1cDelta
The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters.