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IID00238
 UniprotP52298
ProteinNuclear cap-binding protein subunit 2
GeneNCBP2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
156
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-156 Hetero dimer : IID00167Complex
 Evidence X-RAY 1h2u X Reference
       Region 1h2u X 1-3 disorder
       Region 1h2u X 4-152 order
       Region 1h2u X 153-156 disorder
Seq 1-156 Hetero dimer : IID00167Complex
 Evidence X-RAY 1h2u Y Reference
       Region 1h2u Y 1-4 disorder
       Region 1h2u Y 5-151 order
       Region 1h2u Y 152-156 disorder
Seq 1-156 Hetero dimer : IID00167Complex
 Evidence X-RAY 1h2t Z Reference
       Region 1h2t Z 1-4 disorder
       Region 1h2t Z 5-150 order
       Region 1h2t Z 151-156 disorder
Seq 1-156 Hetero trimer : IID00167Complex
 Evidence X-RAY 3fex B Reference
       Region 3fex B 1-34 disorder
       Region 3fex B 35-74 order
       Region 3fex B 75-78 disorder
       Region 3fex B 79-118 order
       Region 3fex B 119-156 disorder
Seq 1-156 Hetero dimer : IID00167Complex
 Evidence X-RAY 5oob G Reference
       Region 5oob G 1-3 disorder
       Region 5oob G 4-152 order
       Region 5oob G 153-156 disorder
 Evidence X-RAY 1n54 B Reference
       Region 1n54 B 1-5 disorder
       Region 1n54 B 6-126 order
       Region 1n54 B 127-156 disorder
 Evidence X-RAY 1n52 B Reference
       Region 1n52 B 1-5 disorder
       Region 1n52 B 6-153 order
       Region 1n52 B 154-156 disorder
 Evidence X-RAY 1h6k Z Reference
       Region 1h6k Z 22-37 disorder
       Region 1h6k Z 38-76 order
       Region 1h6k Z 78-78 order
       Region 1h6k Z 79-80 disorder
       Region 1h6k Z 81-118 order
       Region 1h6k Z 119-120 disorder
 Evidence X-RAY 1h6k Y Reference
       Region 1h6k Y 22-37 disorder
       Region 1h6k Y 38-76 order
       Region 1h6k Y 78-80 disorder
       Region 1h6k Y 81-117 order
       Region 1h6k Y 118-120 disorder
 Evidence X-RAY 1h6k X Reference
       Region 1h6k X 22-37 disorder
       Region 1h6k X 38-76 order
       Region 1h6k X 78-80 disorder
       Region 1h6k X 81-118 order
       Region 1h6k X 119-120 disorder
 Evidence X-RAY 1h2v Z Reference
       Region 1h2v Z 1-32 disorder
       Region 1h2v Z 33-125 order
       Region 1h2v Z 126-156 disorder
Seq 1-156 Hetero trimer : IID00167Complex,IID00734Complex
 Evidence X-RAY 5oo6 W Reference
       Region 5oo6 W 1-3 disorder
       Region 5oo6 W 4-151 order
       Region 5oo6 W 152-156 disorder
 Evidence X-RAY 5oo6 T Reference
       Region 5oo6 T 1-3 disorder
       Region 5oo6 T 4-151 order
       Region 5oo6 T 152-156 disorder
 Evidence X-RAY 5oo6 Q Reference
       Region 5oo6 Q 1-3 disorder
       Region 5oo6 Q 4-151 order
       Region 5oo6 Q 152-156 disorder
 Evidence X-RAY 5oo6 N Reference
       Region 5oo6 N 1-3 disorder
       Region 5oo6 N 4-151 order
       Region 5oo6 N 152-156 disorder
 Evidence X-RAY 5oo6 K Reference
       Region 5oo6 K 1-3 disorder
       Region 5oo6 K 4-151 order
       Region 5oo6 K 152-156 disorder
 Evidence X-RAY 5oo6 H Reference
       Region 5oo6 H 1-3 disorder
       Region 5oo6 H 4-151 order
       Region 5oo6 H 152-156 disorder
 Evidence X-RAY 5oo6 E Reference
       Region 5oo6 E 1-3 disorder
       Region 5oo6 E 4-151 order
       Region 5oo6 E 152-156 disorder
 Evidence X-RAY 5oo6 B Reference
       Region 5oo6 B 1-3 disorder
       Region 5oo6 B 4-151 order
       Region 5oo6 B 152-156 disorder
Seq 1-156 Hetero trimer : IID00153Complex,IID00167Complex
 Evidence X-RAY 3fey B Reference
       Region 3fey B 1-11 disorder
       Region 3fey B 12-15 order
       Region 3fey B 16-29 disorder
       Region 3fey B 30-74 order
       Region 3fey B 75-78 disorder
       Region 3fey B 79-126 order
       Region 3fey B 127-156 disorder
Seq 1-156 Hetero trimer : IID00030Complex,IID00167Complex
 Evidence X-RAY 5oob J Reference
       Region 5oob J 1-3 disorder
       Region 5oob J 4-151 order
       Region 5oob J 152-156 disorder
 Evidence X-RAY 5oob D Reference
       Region 5oob D 1-3 disorder
       Region 5oob D 4-154 order
       Region 5oob D 155-156 disorder
 Evidence X-RAY 5oob B Reference
       Region 5oob B 1-3 disorder
       Region 5oob B 4-155 order
       Region 5oob B 156-156 disorder
SeqProS verified 4-32,126-153 Hetero dimer : IID00167Complex
       Region 1h2u Y 5-151 order
       Region 1h2v Z 1-32 disorder
       Region 1h2v Z 126-156 disorder
SeqProS verified 4-32,126-153 Hetero dimer : IID00167Complex
       Region 5oob G 4-152 order
       Region 1n52 B 6-153 order
       Region 1h2v Z 1-32 disorder
       Region 1h2v Z 126-156 disorder
SeqProS verified 4-32,126-153 Hetero dimer : IID00167Complex
       Region 1h2u X 4-152 order
       Region 1h2v Z 1-32 disorder
       Region 1h2v Z 126-156 disorder
SeqProS verified 4-32,126-153 Hetero dimer : IID00167Complex
       Region 1h2t Z 5-150 order
       Region 1h2v Z 1-32 disorder
       Region 1h2v Z 126-156 disorder
SeqProS verified 4-32,126-153 Hetero trimer : IID00167Complex,IID00734Complex
       Region 5oo6 B 4-151 order
       Region 5oo6 E 4-151 order
       Region 5oo6 H 4-151 order
       Region 5oo6 K 4-151 order
       Region 5oo6 N 4-151 order
       Region 5oo6 Q 4-151 order
       Region 5oo6 T 4-151 order
       Region 5oo6 W 4-151 order
       Region 1h2v Z 1-32 disorder
       Region 1h2v Z 126-156 disorder
SeqProS verified 4-32,126-153 Hetero trimer : IID00030Complex,IID00167Complex
       Region 5oob B 4-155 order
       Region 5oob D 4-154 order
       Region 5oob J 4-151 order
       Region 1h2v Z 1-32 disorder
       Region 1h2v Z 126-156 disorder
Seqphosphorylation
    13-13 Phosphoserine
    18-18 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-28,127-156
Order 29-126
ProS 1-28,127-156
AlphaFold
Disorder 1-8,10-10
Order 9-9,11-156
Pfam Hmmer
PF00076 42-113 6.9e-18
SEG 122-135
Function
Function in SwissProt
Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (PubMed:26382858).