Search Keyword:


Search option:


IID00240
 UniprotQ02078
ProteinMyocyte-specific enhancer factor 2A
GeneMEF2A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
507
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-64,92-95 Homo dimer : Q02080
 Evidence X-RAY 6byy B Reference
       Region 6byy B 1-1 disorder
       Region 6byy B 2-64 order
       Region 6byy B 92-92 order
       Region 6byy B 93-95 disorder
 Evidence X-RAY 6byy A Reference
       Region 6byy A 1-1 disorder
       Region 6byy A 2-64 order
       Region 6byy A 92-92 order
       Region 6byy A 93-95 disorder
Seq 1-64,92-95 Homo dimer : Q02080
 Evidence X-RAY 6bz1 A Reference
       Region 6bz1 A 1-1 disorder
       Region 6bz1 A 2-64 order
       Region 6bz1 A 92-95 disorder
 Evidence X-RAY 6bz1 B Reference
       Region 6bz1 B 1-1 disorder
       Region 6bz1 B 2-64 order
       Region 6bz1 B 92-95 disorder
Seq 1-64,92-95 Homo dimer : Q02080
 Evidence X-RAY 6byy C Reference
       Region 6byy C 1-1 disorder
       Region 6byy C 2-64 order
       Region 6byy C 92-92 order
       Region 6byy C 93-95 disorder
 Evidence X-RAY 6byy D Reference
       Region 6byy D 1-1 disorder
       Region 6byy D 2-64 order
       Region 6byy D 92-95 disorder
Seq 1-64,92-95 Homo dimer : Q02080
 Evidence X-RAY 6bz1 C Reference
       Region 6bz1 C 1-1 disorder
       Region 6bz1 C 2-64 order
       Region 6bz1 C 92-95 disorder
 Evidence X-RAY 6bz1 D Reference
       Region 6bz1 D 1-1 disorder
       Region 6bz1 D 2-64 order
       Region 6bz1 D 92-95 disorder
Seq 2-91 Hetero heptamer : IID00070Complex
 Evidence X-RAY 3p57 J Reference
       Region 3p57 J 2-91 order
 Evidence X-RAY 3p57 I Reference
       Region 3p57 I 2-91 order
 Evidence X-RAY 3p57 D Reference
       Region 3p57 D 2-91 order
 Evidence X-RAY 3p57 C Reference
       Region 3p57 C 2-91 order
 Evidence X-RAY 3p57 B Reference
       Region 3p57 B 2-91 order
 Evidence X-RAY 3p57 A Reference
       Region 3p57 A 2-91 order
Seq 2-91 Homo dimer :
 Evidence NMR 1c7u B Reference
       Region 1c7u B 2-75 order
       Region 1c7u B 76-86 disorder
 Evidence NMR 1c7u A Reference
       Region 1c7u A 2-75 order
       Region 1c7u A 76-86 disorder
 Evidence X-RAY 3mu6 D Reference
       Region 3mu6 D 2-70 order
 Evidence X-RAY 3mu6 C Reference
       Region 3mu6 C 2-70 order
 Evidence X-RAY 3mu6 B Reference
       Region 3mu6 B 2-70 order
 Evidence X-RAY 3mu6 A Reference
       Region 3mu6 A 2-70 order
 Evidence X-RAY 3kov J Reference
       Region 3kov J 2-91 order
 Evidence X-RAY 3kov I Reference
       Region 3kov I 2-91 order
 Evidence X-RAY 3kov B Reference
       Region 3kov B 2-91 order
 Evidence X-RAY 3kov A Reference
       Region 3kov A 2-91 order
 Evidence X-RAY 1egw D Reference
       Region 1egw D 2-72 order
       Region 1egw D 73-78 disorder
 Evidence X-RAY 1egw C Reference
       Region 1egw C 2-73 order
       Region 1egw C 74-78 disorder
 Evidence X-RAY 1egw B Reference
       Region 1egw B 2-73 order
       Region 1egw B 74-78 disorder
 Evidence X-RAY 1egw A Reference
       Region 1egw A 2-72 order
       Region 1egw A 73-78 disorder
Seq 269-280 Hetero dimer : IID50045Complex
 Evidence X-RAY 1lew B Reference
       Region 1lew B 269-269 disorder
       Region 1lew B 270-279 order
       Region 1lew B 280-280 disorder
SeqProS possible 270-279 MAPK docking motif (D-motif). Hetero dimer : IID50045Complex
       Region 1lew B 270-279 order
Seqphosphorylation
    30-30 Phosphoserine
    30-30 Phosphoserine
    98-98 Phosphoserine
    98-98 Phosphoserine
    98-98 Phosphoserine
    453-453 Phosphoserine; by MAPK
    59-59 Phosphoserine; by CK2
    98-98 Phosphoserine
    235-235 Phosphoserine
    255-255 Phosphoserine; by MAPK14
    312-312 Phosphothreonine; by MAPK7 and MAPK14
    312-312 Phosphothreonine; by NLK
    319-319 Phosphothreonine; by MAPK7 and MAPK14
    355-355 Phosphoserine; by MAPK7
    408-408 Phosphoserine; by CDK5
    415-415 Phosphothreonine
Seqacetylation
    249-249 N6-acetyllysine
    403-403 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-6,91-507
Order 7-90
ProS 1-6,91-105,129-136,206-209,216-230,273-276,455-458,467-483,491-507
AlphaFold
Disorder 1-1,93-113,129-431,433-507
Order 2-92,114-128,432-432
Pfam Hmmer
PF00319 9-59 1.3e-24
SEG 159-183 ,256-262 ,290-296 ,309-324 ,420-446 ,453-472
Function
Function in SwissProt
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.