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IID00241
 UniprotQ06609
ProteinDNA repair protein RAD51 homolog 1
GeneRAD51
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
339
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-114 Monomer :
 Evidence NMR 1b22 A Reference
       Region 1b22 A 1-15 disorder
       Region 1b22 A 16-85 order
       Region 1b22 A 16-16 high_rmsd
       Region 1b22 A 85-85 high_rmsd
       Region 1b22 A 86-114 disorder
Seq 1-339 Homo heptamer :
 Evidence X-RAY 5nwl N Reference
       Region 5nwl N 1-20 disorder
       Region 5nwl N 21-270 order
       Region 5nwl N 271-288 disorder
       Region 5nwl N 289-339 order
 Evidence X-RAY 5nwl M Reference
       Region 5nwl M 1-20 disorder
       Region 5nwl M 21-270 order
       Region 5nwl M 271-289 disorder
       Region 5nwl M 290-339 order
 Evidence X-RAY 5nwl L Reference
       Region 5nwl L 1-20 disorder
       Region 5nwl L 21-270 order
       Region 5nwl L 271-288 disorder
       Region 5nwl L 289-339 order
 Evidence X-RAY 5nwl K Reference
       Region 5nwl K 1-20 disorder
       Region 5nwl K 21-270 order
       Region 5nwl K 271-288 disorder
       Region 5nwl K 289-339 order
 Evidence X-RAY 5nwl J Reference
       Region 5nwl J 1-20 disorder
       Region 5nwl J 21-270 order
       Region 5nwl J 271-289 disorder
       Region 5nwl J 290-339 order
 Evidence X-RAY 5nwl I Reference
       Region 5nwl I 1-20 disorder
       Region 5nwl I 21-270 order
       Region 5nwl I 271-289 disorder
       Region 5nwl I 290-339 order
 Evidence X-RAY 5nwl H Reference
       Region 5nwl H 1-20 disorder
       Region 5nwl H 21-270 order
       Region 5nwl H 271-290 disorder
       Region 5nwl H 291-339 order
 Evidence X-RAY 5nwl G Reference
       Region 5nwl G 1-20 disorder
       Region 5nwl G 21-270 order
       Region 5nwl G 271-288 disorder
       Region 5nwl G 289-339 order
 Evidence X-RAY 5nwl F Reference
       Region 5nwl F 1-20 disorder
       Region 5nwl F 21-269 order
       Region 5nwl F 270-289 disorder
       Region 5nwl F 290-339 order
 Evidence X-RAY 5nwl E Reference
       Region 5nwl E 1-20 disorder
       Region 5nwl E 21-270 order
       Region 5nwl E 271-288 disorder
       Region 5nwl E 289-339 order
 Evidence X-RAY 5nwl D Reference
       Region 5nwl D 1-20 disorder
       Region 5nwl D 21-270 order
       Region 5nwl D 271-287 disorder
       Region 5nwl D 288-339 order
 Evidence X-RAY 5nwl C Reference
       Region 5nwl C 1-20 disorder
       Region 5nwl C 21-270 order
       Region 5nwl C 271-288 disorder
       Region 5nwl C 289-339 order
 Evidence X-RAY 5nwl B Reference
       Region 5nwl B 1-20 disorder
       Region 5nwl B 21-270 order
       Region 5nwl B 271-289 disorder
       Region 5nwl B 290-339 order
 Evidence X-RAY 5nwl A Reference
       Region 5nwl A 1-20 disorder
       Region 5nwl A 21-270 order
       Region 5nwl A 271-288 disorder
       Region 5nwl A 289-339 order
Seq 97-339 Hetero tetramer : IID00237Complex
 Evidence X-RAY 1n0w A Reference
       Region 1n0w A 97-97 disorder
       Region 1n0w A 98-229 order
       Region 1n0w A 230-236 disorder
       Region 1n0w A 237-267 order
       Region 1n0w A 268-292 disorder
       Region 1n0w A 293-339 order
Seqphosphorylation
    13-13 Phosphothreonine; by CK2
    14-14 Phosphoserine; by PLK1
    54-54 Phosphotyrosine; by ABL1
    309-309 Phosphothreonine; by CHEK1
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-22,335-339
Order 23-334
ProS 19-22,335-339
AlphaFold
Disorder 1-20,274-281
Order 21-273,282-339
Pfam Hmmer
PF08423 78-338 2.7e-214
SEG 245-256
Function
Function in SwissProt
Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:28575658). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed:26253028).
Biological Process
See also
Diagram with PDB data
BRCA2/RAD51Crystal structure of a RAD51-BRCA2 BRC repeat complex
PALB2/BRCA2Crystal Structure of a PALB2 / BRCA2 complex