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IID00242
 UniprotQ12772
ProteinSterol regulatory element-binding protein 2
GeneSREBF2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1141
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 343-403 Hetero trimer : IID50146Complex
 Evidence X-RAY 1ukl F Reference
       Region 1ukl F 343-403 order
 Evidence X-RAY 1ukl E Reference
       Region 1ukl E 343-403 order
 Evidence X-RAY 1ukl D Reference
       Region 1ukl D 343-403 order
 Evidence X-RAY 1ukl C Reference
       Region 1ukl C 343-403 order
Seqphosphorylation
    855-855 Phosphoserine
    1098-1098 Phosphoserine
 
Prediction
NeProc
Disorder 1-336,397-552,821-834,991-1001,1061-1071,1134-1141
Order 337-396,553-750,756-820,835-990,1006-1060,1072-1133
ProS 4-50,243-248,311-314,333-336,397-418,478-506,517-552,827-834,996-1001,1061-1071,1134-1141
AlphaFold
Disorder 1-332,361-361,403-475,496-530,559-560,566-566,641-654,684-685,729-729,748-757,773-774,776-784,789-789,818-832,849-870,933-933,935-936,959-963,994-1000,1059-1075,1096-1099,1134-1141
Order 333-360,362-402,476-495,531-558,561-565,567-640,655-683,686-728,730-747,758-772,775-775,785-788,790-817,833-848,871-932,934-934,937-958,964-993,1001-1058,1076-1095,1100-1133
Pfam Hmmer
PF00010 331-381 2.6e-17
SEG 5-26 ,52-82 ,98-110 ,128-149 ,179-215 ,221-246 ,394-405 ,628-641 ,973-986
Function
Function in SwissProt
Sterol regulatory element-binding protein 2:Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:32322062).
Processed sterol regulatory element-binding protein 2:Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:12177166, PubMed:32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:7903453, PubMed:12177166). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:12177166, PubMed:32322062).