Search Keyword:


Search option:


IID00245
UniprotQ13185
ProteinChromobox protein homolog 3
GeneCBX3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
183
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 29-81 Hetero dimer : Q92133
 Evidence NMR 2l11 A Reference
       Region 2l11 A 29-81 order
Seq 29-81 Hetero dimer : IID00538Complex
 Evidence X-RAY 3tzd A Reference
       Region 3tzd A 29-81 order
Seq 29-86 Hetero dimer : IID00250Complex
 Evidence X-RAY 3dm1 G Reference
       Region 3dm1 G 29-81 order
       Region 3dm1 G 82-86 disorder
 Evidence X-RAY 3dm1 E Reference
       Region 3dm1 E 29-81 order
       Region 3dm1 E 82-86 disorder
 Evidence X-RAY 3dm1 C Reference
       Region 3dm1 C 29-80 order
       Region 3dm1 C 81-86 disorder
 Evidence X-RAY 3dm1 A Reference
       Region 3dm1 A 29-80 order
       Region 3dm1 A 81-86 disorder
Seq 110-173 Homo tetramer :
 Evidence X-RAY 3kup D Reference
       Region 3kup D 110-113 disorder
       Region 3kup D 114-173 order
 Evidence X-RAY 3kup C Reference
       Region 3kup C 110-111 disorder
       Region 3kup C 112-131 order
       Region 3kup C 132-133 disorder
       Region 3kup C 134-172 order
       Region 3kup C 173-173 disorder
 Evidence X-RAY 3kup B Reference
       Region 3kup B 110-111 disorder
       Region 3kup B 112-173 order
 Evidence X-RAY 3kup A Reference
       Region 3kup A 110-113 disorder
       Region 3kup A 114-172 order
       Region 3kup A 173-173 disorder
Seq 110-176 Hetero trimer : IID00062Complex
 Evidence X-RAY 5t1i B Reference
       Region 5t1i B 110-176 order
 Evidence X-RAY 5t1i A Reference
       Region 5t1i A 110-176 order
Seqphosphorylation
    176-176 Phosphoserine
    99-99 Phosphoserine
    97-97 Phosphoserine
    95-95 Phosphoserine
    93-93 Phosphoserine
Seqacetylation
    50-50 N6-acetyllysine
    44-44 N6-acetyllysine
    10-10 N6-acetyllysine; alternate
    5-5 N6-acetyllysine; alternate
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-32,85-119,180-183
Order 33-84,120-179
ProS 28-32,85-119
AlphaFold
Disorder 1-3,6-28,82-112,177-183
Order 4-5,29-81,113-176
Pfam Hmmer
PF00385 30-79 2.7e-21
PF01393 119-176 1.9e-39
SEG 9-35 ,90-113
Function
Function in SwissProt
Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679).
Biological Process
See also
Diagram with PDB data
EHMT2/CBX3Crystal structure of the complex of human chromobox homolog 3 (CBX3) with peptide