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IID00247
 UniprotQ15637
ProteinSplicing factor 1
GeneSF1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
639
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-25
 Evidence NMR Reference
       Region 1-25 disorder
Seq 1-145 Hetero dimer : IID00147Complex
 Evidence NMR 2m0g A Reference
       Region 2m0g A 1-145 order
       Region 2m0g A 1-10 high_rmsd
       Region 2m0g A 27-35 high_rmsd
       Region 2m0g A 71-97 high_rmsd
       Region 2m0g A 133-145 high_rmsd
 Evidence X-RAY 4fxw D Reference
       Region 4fxw D 14-18 disorder
       Region 4fxw D 19-25 order
       Region 4fxw D 26-31 disorder
       Region 4fxw D 32-126 order
       Region 4fxw D 127-127 disorder
       Region 4fxw D 128-132 order
 Evidence X-RAY 4fxw B Reference
       Region 4fxw B 14-19 disorder
       Region 4fxw B 20-25 order
       Region 4fxw B 26-33 disorder
       Region 4fxw B 34-128 order
       Region 4fxw B 129-132 disorder
Seq 13-25 Hetero dimer : IID00147Complex
 Evidence NMR 1opi B Reference
       Region 1opi B 13-25 order
 Evidence NMR 1o0p B Reference
       Region 1o0p B 13-25 order
Seq 26-145 Monomer :
 Evidence NMR 2m09 A Reference
       Region 2m09 A 27-145 order
       Region 2m09 A 27-36 high_rmsd
       Region 2m09 A 75-83 high_rmsd
       Region 2m09 A 89-91 high_rmsd
       Region 2m09 A 134-145 high_rmsd
 Evidence X-RAY 4fxx D Reference
       Region 4fxx D 26-72 order
       Region 4fxx D 73-83 disorder
       Region 4fxx D 84-90 order
       Region 4fxx D 91-92 disorder
       Region 4fxx D 93-132 order
 Evidence X-RAY 4fxx C Reference
       Region 4fxx C 26-32 disorder
       Region 4fxx C 33-73 order
       Region 4fxx C 74-81 disorder
       Region 4fxx C 82-131 order
       Region 4fxx C 132-132 disorder
 Evidence X-RAY 4fxx B Reference
       Region 4fxx B 26-35 disorder
       Region 4fxx B 36-72 order
       Region 4fxx B 73-82 disorder
       Region 4fxx B 83-131 order
       Region 4fxx B 132-132 disorder
 Evidence X-RAY 4fxx A Reference
       Region 4fxx A 26-32 disorder
       Region 4fxx A 33-74 order
       Region 4fxx A 75-80 disorder
       Region 4fxx A 81-131 order
       Region 4fxx A 132-132 disorder
Seq 133-260 Monomer :
 Evidence NMR 1k1g A Reference
       Region 1k1g A 133-133 disorder
       Region 1k1g A 134-255 order
       Region 1k1g A 191-192 high_rmsd
       Region 1k1g A 256-260 disorder
SeqProS verified 13-25 Hetero dimer : IID00147Complex
       Region 1opi B 13-25 order
       Region 1o0p B 13-25 order
       Region 1-25 disorder
Seqphosphorylation
    463-463 Phosphoserine
    14-14 Phosphoserine
    20-20 Phosphoserine; by PKG
    80-80 Phosphoserine
    82-82 Phosphoserine
    87-87 Phosphotyrosine
    89-89 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-27,77-81,181-198,299-639
Order 28-76,82-180,199-298
ProS 18-27,77-81,181-198,306-324,345-351,362-415,438-447,610-630
AlphaFold
Disorder 1-7,9-36,71-78,80-80,82-82,133-134,185-199,256-275,295-305,321-419,423-423,426-426,431-478,485-499,501-507,510-581,589-599,606-630,632-632,636-639
Order 8-8,37-70,79-79,81-81,83-132,135-184,200-255,276-294,306-320,420-422,424-425,427-430,479-484,500-500,508-509,582-588,600-605,631-631,633-635
Pfam Hmmer
PF00013 149-222 8.1e-06
PF00098 277-294 0.00038
SEG 335-358 ,378-402 ,406-446 ,468-524 ,529-534 ,542-561 ,564-609 ,615-637
Function
Function in SwissProt
Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.