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IID00250
 UniprotQ96KQ7
ProteinHistone-lysine N-methyltransferase EHMT2
GeneEHMT2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1210
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 179-190 Hetero dimer : IID00245Complex
 Evidence X-RAY 3dm1 B Reference
       Region 3dm1 B 179-186 order
       Region 3dm1 B 187-190 disorder
 Evidence X-RAY 3dm1 D Reference
       Region 3dm1 D 179-179 disorder
       Region 3dm1 D 180-189 order
       Region 3dm1 D 190-190 disorder
 Evidence X-RAY 3dm1 F Reference
       Region 3dm1 F 179-187 order
       Region 3dm1 F 188-190 disorder
 Evidence X-RAY 3dm1 H Reference
       Region 3dm1 H 179-185 order
       Region 3dm1 H 186-190 disorder
Seq 913-1193 Homo dimer :
 Evidence X-RAY 3rjw A Reference
       Region 3rjw A 913-917 disorder
       Region 3rjw A 918-1162 order
       Region 3rjw A 1163-1164 disorder
       Region 3rjw A 1165-1187 order
       Region 3rjw A 1188-1193 disorder
 Evidence X-RAY 3rjw B Reference
       Region 3rjw B 913-920 disorder
       Region 3rjw B 921-1091 order
       Region 3rjw B 1092-1094 disorder
       Region 3rjw B 1095-1193 order
 Evidence X-RAY 4nvq A Reference
       Region 4nvq A 913-915 disorder
       Region 4nvq A 916-1089 order
       Region 4nvq A 1090-1093 disorder
       Region 4nvq A 1094-1163 order
       Region 4nvq A 1164-1164 disorder
       Region 4nvq A 1165-1187 order
       Region 4nvq A 1188-1193 disorder
 Evidence X-RAY 4nvq B Reference
       Region 4nvq B 913-917 disorder
       Region 4nvq B 918-987 order
       Region 4nvq B 988-992 disorder
       Region 4nvq B 993-1090 order
       Region 4nvq B 1091-1095 disorder
       Region 4nvq B 1096-1190 order
       Region 4nvq B 1191-1193 disorder
 Evidence X-RAY 5tuy A Reference
       Region 5tuy A 921-1187 order
 Evidence X-RAY 5tuy B Reference
       Region 5tuy B 921-922 disorder
       Region 5tuy B 923-1090 order
       Region 5tuy B 1091-1093 disorder
       Region 5tuy B 1094-1187 order
 Evidence X-RAY 5vsc A Reference
       Region 5vsc A 916-917 disorder
       Region 5vsc A 918-1090 order
       Region 5vsc A 1091-1094 disorder
       Region 5vsc A 1095-1190 order
 Evidence X-RAY 5vsc B Reference
       Region 5vsc B 916-1090 order
       Region 5vsc B 1091-1093 disorder
       Region 5vsc B 1094-1190 order
Seq 913-1193 Homo tetramer :
 Evidence X-RAY 5ttf A Reference
       Region 5ttf A 913-917 disorder
       Region 5ttf A 918-1090 order
       Region 5ttf A 1091-1094 disorder
       Region 5ttf A 1095-1186 order
       Region 5ttf A 1187-1193 disorder
 Evidence X-RAY 5ttf B Reference
       Region 5ttf B 913-917 disorder
       Region 5ttf B 918-1091 order
       Region 5ttf B 1092-1094 disorder
       Region 5ttf B 1095-1188 order
       Region 5ttf B 1189-1193 disorder
 Evidence X-RAY 5ttf C Reference
       Region 5ttf C 913-920 disorder
       Region 5ttf C 921-1091 order
       Region 5ttf C 1092-1094 disorder
       Region 5ttf C 1095-1188 order
       Region 5ttf C 1189-1193 disorder
 Evidence X-RAY 5ttf D Reference
       Region 5ttf D 913-917 disorder
       Region 5ttf D 918-1090 order
       Region 5ttf D 1091-1094 disorder
       Region 5ttf D 1095-1182 order
       Region 5ttf D 1183-1193 disorder
Seq 913-1193 Monomer :
 Evidence X-RAY 2o8j A Reference
       Region 2o8j A 913-919 disorder
       Region 2o8j A 920-1090 order
       Region 2o8j A 1091-1094 disorder
       Region 2o8j A 1095-1160 order
       Region 2o8j A 1161-1164 disorder
       Region 2o8j A 1165-1181 order
       Region 2o8j A 1182-1193 disorder
 Evidence X-RAY 2o8j B Reference
       Region 2o8j B 913-921 disorder
       Region 2o8j B 922-1192 order
       Region 2o8j B 1193-1193 disorder
 Evidence X-RAY 2o8j C Reference
       Region 2o8j C 913-921 disorder
       Region 2o8j C 922-1089 order
       Region 2o8j C 1090-1094 disorder
       Region 2o8j C 1095-1188 order
       Region 2o8j C 1189-1193 disorder
 Evidence X-RAY 2o8j D Reference
       Region 2o8j D 913-921 disorder
       Region 2o8j D 922-1089 order
       Region 2o8j D 1090-1095 disorder
       Region 2o8j D 1096-1159 order
       Region 2o8j D 1160-1165 disorder
       Region 2o8j D 1166-1181 order
       Region 2o8j D 1182-1193 disorder
 Evidence X-RAY 3k5k A Reference
       Region 3k5k A 913-916 disorder
       Region 3k5k A 917-1092 order
       Region 3k5k A 1093-1094 disorder
       Region 3k5k A 1095-1190 order
       Region 3k5k A 1191-1193 disorder
 Evidence X-RAY 3k5k B Reference
       Region 3k5k B 913-918 disorder
       Region 3k5k B 919-1091 order
       Region 3k5k B 1092-1094 disorder
       Region 3k5k B 1095-1190 order
       Region 3k5k B 1191-1193 disorder
 Evidence X-RAY 5vse A Reference
       Region 5vse A 917-918 disorder
       Region 5vse A 919-1091 order
       Region 5vse A 1092-1094 disorder
       Region 5vse A 1095-1190 order
 Evidence X-RAY 5vse B Reference
       Region 5vse B 917-1090 order
       Region 5vse B 1091-1094 disorder
       Region 5vse B 1095-1190 order
Seq 913-1193 Hetero dimer : IID00062Complex
 Evidence X-RAY 5t0k A Reference
       Region 5t0k A 913-919 disorder
       Region 5t0k A 920-1090 order
       Region 5t0k A 1091-1094 disorder
       Region 5t0k A 1095-1187 order
       Region 5t0k A 1188-1193 disorder
 Evidence X-RAY 5t0k B Reference
       Region 5t0k B 913-920 disorder
       Region 5t0k B 921-1003 order
       Region 5t0k B 1004-1010 disorder
       Region 5t0k B 1011-1192 order
       Region 5t0k B 1193-1193 disorder
 Evidence X-RAY 5t0m A Reference
       Region 5t0m A 913-920 disorder
       Region 5t0m A 921-1090 order
       Region 5t0m A 1091-1094 disorder
       Region 5t0m A 1095-1184 order
       Region 5t0m A 1185-1193 disorder
 Evidence X-RAY 5t0m B Reference
       Region 5t0m B 913-915 disorder
       Region 5t0m B 916-1186 order
       Region 5t0m B 1187-1193 disorder
Seq 916-1189 Hetero tetramer : IID00062Complex
 Evidence X-RAY 5jhn A Reference
       Region 5jhn A 916-1188 order
       Region 5jhn A 1189-1189 disorder
 Evidence X-RAY 5jhn B Reference
       Region 5jhn B 916-918 disorder
       Region 5jhn B 919-1090 order
       Region 5jhn B 1091-1094 disorder
       Region 5jhn B 1095-1189 order
 Evidence X-RAY 5jin A Reference
       Region 5jin A 916-1188 order
       Region 5jin A 1189-1189 disorder
 Evidence X-RAY 5jin B Reference
       Region 5jin B 916-918 disorder
       Region 5jin B 919-1090 order
       Region 5jin B 1091-1094 disorder
       Region 5jin B 1095-1189 order
 Evidence X-RAY 5jiy A Reference
       Region 5jiy A 916-1188 order
       Region 5jiy A 1189-1189 disorder
 Evidence X-RAY 5jiy B Reference
       Region 5jiy B 916-918 disorder
       Region 5jiy B 919-1090 order
       Region 5jiy B 1091-1094 disorder
       Region 5jiy B 1095-1189 order
 Evidence X-RAY 5jj0 A Reference
       Region 5jj0 A 916-1188 order
       Region 5jj0 A 1189-1189 disorder
 Evidence X-RAY 5jj0 B Reference
       Region 5jj0 B 916-918 disorder
       Region 5jj0 B 919-1090 order
       Region 5jj0 B 1091-1094 disorder
       Region 5jj0 B 1095-1189 order
Seqphosphorylation
    40-40 Phosphoserine
    44-44 Phosphothreonine
    47-47 Phosphoserine
    140-140 Phosphoserine
    173-173 Phosphoserine
    232-232 Phosphoserine
    242-242 Phosphoserine
    246-246 Phosphoserine
    350-350 Phosphoserine
    412-412 Phosphoserine
    413-413 Phosphoserine
    555-555 Phosphothreonine
    569-569 Phosphoserine
    1204-1204 Phosphoserine
    1210-1210 Phosphothreonine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-283,334-422,552-631,1183-1210
Order 284-333,423-551,632-1182
ProS 26-40,127-131,177-182,270-273,348-355,385-397,417-422,612-615,627-631,1183-1188
AlphaFold
Disorder 1-425,513-513,551-606,643-647,910-918,1193-1210
Order 426-512,514-550,607-642,648-909,919-1192
Pfam Hmmer
PF00023 684-716 9.3e-10
PF00023 717-749 0.00036
PF00023 750-783 3.2e-08
PF00023 784-816 1.3e-08
PF00023 817-849 0.00075
PF00023 850-882 5.3e-09
PF05033 925-1030 4.6e-43
PF00856 1032-1162 9.9e-54
SEG 2-23 ,96-110 ,114-128 ,155-176 ,232-242 ,300-326 ,331-350 ,354-371 ,555-567 ,1194-1207
Function
Function in SwissProt
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.
Biological Process
Diagram with PDB data
EHMT2/CBX3Crystal structure of the complex of human chromobox homolog 3 (CBX3) with peptide
See also
Diagram with PDB data
REST/Sin3bSolution structure of the NRSF/REST-mSin3B PAH1 complex