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IID00258
 UniprotO43516
ProteinWAS/WASL-interacting protein family member 1
GeneWIPF1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
503
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 29-60 Hetero trimer : IID50082Complex,P00639
 Evidence X-RAY 2a41 C Reference
       Region 2a41 C 29-60 order
Seqphosphorylation
    142-142 Phosphoserine
    234-234 Phosphoserine
    340-340 Phosphoserine
    345-345 Phosphothreonine
    350-350 Phosphoserine
 
Prediction
NeProc
Disorder 1-445,454-463,477-503
Order 446-453,464-476
ProS 13-23,33-61,103-108,116-120,260-265,437-445,454-463,477-482,490-503
AlphaFold
Disorder 15-21,62-101,114-186,188-264,266-312,315-381,383-412,414-414,416-417,421-447,478-479,481-494
Order 1-14,22-61,102-113,187-187,265-265,313-314,382-382,413-413,415-415,418-420,448-477,480-480,495-503
Pfam Hmmer
PF02205 32-49 9.7e-05
SEG 2-13 ,64-104 ,121-137 ,140-156 ,161-174 ,178-193 ,201-227 ,238-257 ,264-270 ,283-326 ,339-390 ,408-434 ,481-494
Function
Function in SwissProt
Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.