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IID00259
 UniprotO60673
ProteinDNA polymerase zeta catalytic subunit
GeneREV3L
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
3130
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1847-1898 Hetero tetramer : IID00284Complex,IID00285Complex
 Evidence X-RAY 4gk5 C Reference
       Region 4gk5 C 1847-1873 disorder
       Region 4gk5 C 1874-1893 order
       Region 4gk5 C 1894-1898 disorder
Seq 1847-1898 Hetero trimer : IID00284Complex,IID00285Complex
 Evidence X-RAY 4gk5 D Reference
       Region 4gk5 D 1847-1873 disorder
       Region 4gk5 D 1874-1893 order
       Region 4gk5 D 1894-1898 disorder
 Evidence X-RAY 4gk0 D Reference
       Region 4gk0 D 1847-1873 disorder
       Region 4gk0 D 1874-1893 order
       Region 4gk0 D 1894-1898 disorder
 Evidence X-RAY 4gk0 C Reference
       Region 4gk0 C 1847-1873 disorder
       Region 4gk0 C 1874-1893 order
       Region 4gk0 C 1894-1898 disorder
Seq 1847-1898 Hetero dimer : IID00285Complex
 Evidence X-RAY 3abe Z Reference
       Region 3abe Z 1847-1874 disorder
       Region 3abe Z 1875-1895 order
       Region 3abe Z 1896-1898 disorder
 Evidence X-RAY 3abd Y Reference
       Region 3abd Y 1847-1873 disorder
       Region 3abd Y 1874-1895 order
       Region 3abd Y 1896-1898 disorder
 Evidence X-RAY 3abd X Reference
       Region 3abd X 1847-1873 disorder
       Region 3abd X 1874-1894 order
       Region 3abd X 1895-1898 disorder
Seq 1847-1898 Hetero trimer : IID00285Complex
 Evidence X-RAY 3vu7 Z Reference
       Region 3vu7 Z 1847-1872 disorder
       Region 3vu7 Z 1873-1893 order
       Region 3vu7 Z 1894-1898 disorder
 Evidence X-RAY 4ext B Reference
       Region 4ext B 1873-1895 order
Seqphosphorylation
    1030-1030 Phosphoserine
    1724-1724 Phosphoserine
    1967-1967 Phosphoserine
    1041-1041 Phosphothreonine
 
Prediction
NeProc
Disorder 196-202,276-289,320-799,814-968,1043-1077,1117-1126,1133-1636,1681-1870,1961-1984,2021-2178,2184-2228,2235-2241,2246-2255,2583-2587,3022-3029
Order 1-195,203-275,290-319,800-813,969-1042,1078-1116,1127-1132,1637-1680,1871-1955,1985-2020,2179-2183,2229-2234,2242-2245,2256-2283,2290-2582,2588-3021,3030-3130
ProS 196-202,286-289,334-386,397-423,445-479,487-494,518-530,558-568,583-586,602-636,647-693,704-716,721-739,750-758,767-799,814-834,855-865,890-901,909-931,941-965,1046-1054,1064-1077,1122-1126,1133-1140,1146-1164,1171-1176,1225-1229,1239-1250,1261-1265,1272-1277,1291-1310,1315-1320,1343-1361,1370-1375,1415-1423,1428-1431,1443-1462,1468-1493,1499-1512,1518-1537,1556-1558,1594-1599,1607-1636,1681-1684,1693-1701,1715-1728,1743-1748,1964-1984,2021-2071,2080-2085,2108-2178,2184-2228,2235-2241,2246-2255,2583-2587
AlphaFold
Disorder 68-69,186-212,252-257,259-259,279-293,312-1888,1890-1891,1893-1895,1897-2010,2012-2266,2268-2294,2351-2363,2443-2445,2447-2447,2452-2452,3014-3040,3094-3096
Order 1-67,70-185,213-251,258-258,260-278,294-311,1889-1889,1892-1892,1896-1896,2011-2011,2267-2267,2295-2350,2364-2442,2446-2446,2448-2451,2453-3013,3041-3093,3097-3130
Pfam Hmmer
PF03104 2190-2484 1.5e-06
PF00136 2558-3036 1.5e-98
SEG 494-511 ,842-854 ,960-970 ,1043-1058 ,1136-1148 ,1188-1199 ,1849-1865 ,2038-2057 ,2101-2127 ,3070-3082
Function
Function in SwissProt
Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.