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IID00260
 UniprotO94916
ProteinNuclear factor of activated T-cells 5
GeneNFAT5
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1531
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 246-546 Homo dimer :
 Evidence X-RAY 1imh D Reference
       Region 1imh D 264-544 order
 Evidence X-RAY 1imh C Reference
       Region 1imh C 246-263 disorder
       Region 1imh C 264-544 order
       Region 1imh C 545-546 disorder
Seqdisorder 246-263,545-546
 Evidence X-RAY Reference
       Region 246-263 disorder
       Region 545-546 disorder
Seqphosphorylation
    120-120 Phosphoserine
    155-155 Phosphoserine
    561-561 Phosphoserine
    134-134 Phosphoserine
    135-135 Phosphothreonine; by CDK5
Seqacetylation
    122-122 N6-acetyllysine
 
Prediction
NeProc
Disorder 23-307,554-1531
Order 1-22,308-553
ProS 23-37,52-61,146-156,187-207,223-241,268-307,554-566,584-589,605-611,768-782,798-801,810-813,1372-1375,1420-1423,1445-1457,1511-1531
AlphaFold
Disorder 1-265,547-1531
Order 266-546
Pfam Hmmer
PF00554 282-439 3.8e-36
PF01833 445-542 1.5e-17
SEG 52-98 ,179-192 ,646-657 ,731-759 ,780-812 ,879-888 ,901-913 ,960-980 ,1037-1049 ,1104-1109 ,1248-1266 ,1320-1330 ,1475-1486
Function
Function in SwissProt
Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394).