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IID00261
 UniprotO95630
ProteinSTAM-binding protein
GeneSTAMBP
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
424
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-146 Hetero tetramer : IID00230Complex
 Evidence X-RAY 2xze A Reference
       Region 2xze A 1-1 disorder
       Region 2xze A 2-142 order
       Region 2xze A 143-146 disorder
 Evidence X-RAY 2xze B Reference
       Region 2xze B 1-1 disorder
       Region 2xze B 2-139 order
       Region 2xze B 140-146 disorder
Seq 219-424 Monomer :
 Evidence X-RAY 3rzv A Reference
       Region 3rzv A 219-245 disorder
       Region 3rzv A 246-424 order
 Evidence X-RAY 3rzu G Reference
       Region 3rzu G 243-251 disorder
       Region 3rzu G 252-424 order
 Evidence X-RAY 3rzu F Reference
       Region 3rzu F 243-251 disorder
       Region 3rzu F 252-424 order
 Evidence X-RAY 3rzu E Reference
       Region 3rzu E 243-251 disorder
       Region 3rzu E 252-424 order
 Evidence X-RAY 3rzu D Reference
       Region 3rzu D 243-248 disorder
       Region 3rzu D 249-424 order
 Evidence X-RAY 3rzu C Reference
       Region 3rzu C 243-247 disorder
       Region 3rzu C 248-424 order
 Evidence X-RAY 3rzu B Reference
       Region 3rzu B 243-248 disorder
       Region 3rzu B 249-424 order
 Evidence X-RAY 3rzu A Reference
       Region 3rzu A 243-248 disorder
       Region 3rzu A 249-424 order
Seqdisorder 228-241
 Evidence NMR Reference
       Region 228-241 disorder
Seq 228-241 Hetero dimer : O75886
 Evidence NMR 5ixf B Reference
       Region 5ixf B 228-241 order
       Region 5ixf B 241-241 high_rmsd
SeqProS verified 228-241 Hetero dimer : O75886
       Region 5ixf B 228-241 order
       Region 228-241 disorder
Seqphosphorylation
    2-2 Phosphoserine
    48-48 Phosphoserine
    243-243 Phosphoserine
    245-245 Phosphoserine
    247-247 Phosphoserine
 
Prediction
NeProc
Disorder 1-9,178-250
Order 10-177,251-424
ProS 1-9,178-201,207-229,244-250
AlphaFold
Disorder 1-2,184-248
Order 3-183,249-424
Pfam Hmmer
PF01398 252-361 4.4e-33
SEG 112-135 ,143-161
Function
Function in SwissProt
Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.