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IID00262
 UniprotP00533
ProteinEpidermal growth factor receptor
GeneEGFR
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1210
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-642 Hetero dimer :
 Evidence X-RAY 3qwq A Reference
       Region 3qwq A 1-25 disorder
       Region 3qwq A 26-638 order
       Region 3qwq A 639-642 disorder
Seq 1-643 Hetero trimer :
 Evidence X-RAY 5xwd A Reference
       Region 5xwd A 1-27 disorder
       Region 5xwd A 28-638 order
       Region 5xwd A 639-643 disorder
Seq 25-525 Hetero tetramer : IID00290Complex
 Evidence X-RAY 1mox B Reference
       Region 1mox B 25-525 order
 Evidence X-RAY 1mox A Reference
       Region 1mox A 25-329 order
       Region 1mox A 330-330 disorder
       Region 1mox A 331-524 order
       Region 1mox A 525-525 disorder
Seq 25-525 Hetero dimer : Q6UW88
 Evidence X-RAY 5wb8 A Reference
       Region 5wb8 A 25-26 disorder
       Region 5wb8 A 27-126 order
       Region 5wb8 A 127-127 disorder
       Region 5wb8 A 128-525 order
Seq 25-525 Hetero tetramer : O14944
 Evidence X-RAY 5wb7 C Reference
       Region 5wb7 C 25-25 disorder
       Region 5wb7 C 26-525 order
 Evidence X-RAY 5wb7 B Reference
       Region 5wb7 B 25-25 disorder
       Region 5wb7 B 26-525 order
 Evidence X-RAY 5wb7 D Reference
       Region 5wb7 D 25-25 disorder
       Region 5wb7 D 26-524 order
       Region 5wb7 D 525-525 disorder
 Evidence X-RAY 5wb7 A Reference
       Region 5wb7 A 25-25 disorder
       Region 5wb7 A 26-525 order
Seq 25-525 Hetero dimer : Q6UW88
 Evidence X-RAY 5wb8 D Reference
       Region 5wb8 D 25-183 order
       Region 5wb8 D 184-185 disorder
       Region 5wb8 D 186-525 order
Seq 25-642 Hetero dimer : IID00263Complex
 Evidence X-RAY 1nql A Reference
       Region 1nql A 25-26 disorder
       Region 1nql A 27-638 order
       Region 1nql A 639-642 disorder
 Evidence X-RAY 3njp B Reference
       Region 3njp B 25-638 order
 Evidence X-RAY 3njp A Reference
       Region 3njp A 25-638 order
Seq 25-642 Hetero trimer :
 Evidence X-RAY 1yy9 A Reference
       Region 1yy9 A 25-25 disorder
       Region 1yy9 A 26-638 order
       Region 1yy9 A 639-642 disorder
Seq 25-642 Hetero tetramer :
 Evidence X-RAY 4krp A Reference
       Region 4krp A 25-27 disorder
       Region 4krp A 28-156 order
       Region 4krp A 157-231 disorder
       Region 4krp A 232-636 order
       Region 4krp A 637-642 disorder
Seq 25-642 Hetero tetramer :
 Evidence X-RAY 4kro A Reference
       Region 4kro A 25-27 disorder
       Region 4kro A 28-124 order
       Region 4kro A 125-131 disorder
       Region 4kro A 132-207 order
       Region 4kro A 208-231 disorder
       Region 4kro A 232-628 order
       Region 4kro A 629-642 disorder
Seq 25-645 Hetero trimer :
 Evidence X-RAY 4uv7 A Reference
       Region 4uv7 A 25-170 order
       Region 4uv7 A 171-187 disorder
       Region 4uv7 A 188-637 order
       Region 4uv7 A 638-645 disorder
Seq 25-646 Hetero tetramer : IID00263Complex
 Evidence X-RAY 3njp B Reference
       Region 3njp B 25-638 order
 Evidence X-RAY 3njp A Reference
       Region 3njp A 25-638 order
 Evidence X-RAY 1ivo B Reference
       Region 1ivo B 25-26 disorder
       Region 1ivo B 27-536 order
       Region 1ivo B 537-646 disorder
 Evidence X-RAY 1ivo A Reference
       Region 1ivo A 25-25 disorder
       Region 1ivo A 26-536 order
       Region 1ivo A 537-646 disorder
Seq 26-637 Hetero dimer : E0ACT6,Q4G1L3
 Evidence X-RAY 4uip A Reference
       Region 4uip A 26-637 order
Seq 311-326 Hetero trimer :
 Evidence X-RAY 3g5v C Reference
       Region 3g5v C 311-326 order
Seq 311-326 Hetero trimer :
 Evidence X-RAY 3g5y E Reference
       Region 3g5y E 311-326 order
Seq 334-538 Hetero trimer :
 Evidence X-RAY 3p0y A Reference
       Region 3p0y A 334-527 order
       Region 3p0y A 528-538 disorder
Seq 335-525 Hetero trimer :
 Evidence X-RAY 5sx5 M Reference
       Region 5sx5 M 335-525 order
Seq 335-525 Hetero trimer :
 Evidence X-RAY 5sx4 M Reference
       Region 5sx4 M 335-335 disorder
       Region 5sx4 M 336-525 order
Seq 335-525 Hetero trimer :
 Evidence X-RAY 5sx4 N Reference
       Region 5sx4 N 335-338 order
       Region 5sx4 N 339-344 disorder
       Region 5sx4 N 345-525 order
Seq 335-525 Hetero trimer :
 Evidence X-RAY 5sx5 N Reference
       Region 5sx5 N 335-525 order
Seq 335-538 Hetero dimer :
 Evidence X-RAY 4krm G Reference
       Region 4krm G 335-527 order
       Region 4krm G 528-534 disorder
       Region 4krm G 535-535 order
       Region 4krm G 536-538 disorder
Seq 335-538 Hetero trimer :
 Evidence X-RAY 6b3s B Reference
       Region 6b3s B 335-526 order
       Region 6b3s B 527-538 disorder
Seq 335-538 Hetero trimer :
 Evidence X-RAY 6b3s I Reference
       Region 6b3s I 335-526 order
       Region 6b3s I 527-538 disorder
Seq 335-538 Hetero dimer :
 Evidence X-RAY 4krm A Reference
       Region 4krm A 335-527 order
       Region 4krm A 528-538 disorder
Seq 335-538 Hetero dimer :
 Evidence X-RAY 4krm E Reference
       Region 4krm E 335-527 order
       Region 4krm E 528-538 disorder
Seq 335-538 Hetero dimer :
 Evidence X-RAY 4krm C Reference
       Region 4krm C 335-527 order
       Region 4krm C 528-538 disorder
Seq 335-538 Hetero dimer :
 Evidence X-RAY 4krm I Reference
       Region 4krm I 335-525 order
       Region 4krm I 526-538 disorder
Seq 335-538 Hetero trimer : P01834,P01857
 Evidence X-RAY 3c09 D Reference
       Region 3c09 D 336-524 order
       Region 3c09 D 525-538 disorder
 Evidence X-RAY 3b2u V Reference
       Region 3b2u V 335-526 order
       Region 3b2u V 527-538 disorder
 Evidence X-RAY 3b2u S Reference
       Region 3b2u S 335-526 order
       Region 3b2u S 527-538 disorder
 Evidence X-RAY 3b2u P Reference
       Region 3b2u P 335-526 order
       Region 3b2u P 527-538 disorder
 Evidence X-RAY 3b2u M Reference
       Region 3b2u M 335-526 order
       Region 3b2u M 527-538 disorder
 Evidence X-RAY 3b2u I Reference
       Region 3b2u I 335-526 order
       Region 3b2u I 527-538 disorder
 Evidence X-RAY 3b2u A Reference
       Region 3b2u A 335-526 order
       Region 3b2u A 527-538 disorder
Seq 335-538 Hetero dimer :
 Evidence X-RAY 4krm K Reference
       Region 4krm K 335-526 order
       Region 4krm K 527-538 disorder
Seq 335-538 Hetero trimer :
 Evidence X-RAY 6b3s A Reference
       Region 6b3s A 335-524 order
       Region 6b3s A 525-538 disorder
Seq 335-538 Hetero trimer : P01834,P01857,Q6GMX6
 Evidence X-RAY 3b2u E Reference
       Region 3b2u E 335-526 order
       Region 3b2u E 527-538 disorder
Seq 335-538 Hetero trimer :
 Evidence X-RAY 6b3s E Reference
       Region 6b3s E 335-526 order
       Region 6b3s E 527-538 disorder
Seq 335-538 Hetero dimer :
 Evidence X-RAY 4krl A Reference
       Region 4krl A 335-535 order
       Region 4krl A 536-538 disorder
Seq 335-538 Hetero trimer : P01834,P01857,Q6GMX6
 Evidence X-RAY 3b2u B Reference
       Region 3b2u B 335-526 order
       Region 3b2u B 527-538 disorder
Seq 336-538 Hetero trimer : P01834,P01857
 Evidence X-RAY 3c09 A Reference
       Region 3c09 A 336-524 order
       Region 3c09 A 525-538 disorder
Seq 634-677 Hetero dimer : IID00293Complex
 Evidence NMR 2ks1 B Reference
       Region 2ks1 B 634-677 order
       Region 2ks1 B 634-642 high_rmsd
       Region 2ks1 B 673-677 high_rmsd
Seq 634-677 Homo dimer :
 Evidence NMR 5lv6 B Reference
       Region 5lv6 B 634-677 order
       Region 5lv6 B 634-642 high_rmsd
       Region 5lv6 B 671-677 high_rmsd
 Evidence NMR 5lv6 A Reference
       Region 5lv6 A 634-677 order
       Region 5lv6 A 634-641 high_rmsd
       Region 5lv6 A 672-677 high_rmsd
 Evidence NMR 2m0b B Reference
       Region 2m0b B 634-677 order
       Region 2m0b B 634-641 high_rmsd
       Region 2m0b B 671-677 high_rmsd
 Evidence NMR 2m0b A Reference
       Region 2m0b A 634-677 order
       Region 2m0b A 634-640 high_rmsd
       Region 2m0b A 672-677 high_rmsd
Seq 642-690 Monomer :
 Evidence NMR 2n5s A Reference
       Region 2n5s A 642-690 order
       Region 2n5s A 642-642 high_rmsd
       Region 2n5s A 688-690 high_rmsd
Seq 642-697 Homo dimer :
 Evidence NMR 2m20 B Reference
       Region 2m20 B 642-697 order
       Region 2m20 B 689-697 high_rmsd
 Evidence NMR 2m20 A Reference
       Region 2m20 A 642-697 order
       Region 2m20 A 689-697 high_rmsd
Seq 669-721 Monomer :
 Evidence NMR 1z9i A Reference
       Region 1z9i A 669-696 disorder
       Region 1z9i A 669-696 high_rmsd
       Region 1z9i A 697-721 order
Seq 669-1022 Homo dimer :
 Evidence X-RAY 2jiu B Reference
       Region 2jiu B 695-1003 order
       Region 2jiu B 1004-1022 disorder
 Evidence X-RAY 2jiu A Reference
       Region 2jiu A 695-695 disorder
       Region 2jiu A 696-992 order
       Region 2jiu A 993-1009 disorder
       Region 2jiu A 1010-1015 order
       Region 2jiu A 1016-1022 disorder
 Evidence X-RAY 2jit B Reference
       Region 2jit B 696-696 disorder
       Region 2jit B 697-985 order
       Region 2jit B 986-988 disorder
       Region 2jit B 989-990 order
       Region 2jit B 991-992 disorder
       Region 2jit B 993-1004 order
       Region 2jit B 1005-1009 disorder
       Region 2jit B 1010-1018 order
       Region 2jit B 1019-1022 disorder
 Evidence X-RAY 2jit A Reference
       Region 2jit A 696-986 order
       Region 2jit A 987-1008 disorder
       Region 2jit A 1009-1016 order
       Region 2jit A 1017-1022 disorder
 Evidence X-RAY 4zse C Reference
       Region 4zse C 695-699 disorder
       Region 4zse C 700-862 order
       Region 4zse C 863-875 disorder
       Region 4zse C 876-1013 order
       Region 4zse C 1014-1022 disorder
 Evidence X-RAY 4zse B Reference
       Region 4zse B 695-697 disorder
       Region 4zse B 698-862 order
       Region 4zse B 863-874 disorder
       Region 4zse B 875-1022 order
 Evidence X-RAY 4zse D Reference
       Region 4zse D 695-700 disorder
       Region 4zse D 701-749 order
       Region 4zse D 750-751 disorder
       Region 4zse D 752-863 order
       Region 4zse D 864-875 disorder
       Region 4zse D 876-1005 order
       Region 4zse D 1006-1009 disorder
       Region 4zse D 1010-1015 order
       Region 4zse D 1016-1022 disorder
 Evidence X-RAY 4zse A Reference
       Region 4zse A 695-698 disorder
       Region 4zse A 699-862 order
       Region 4zse A 863-874 disorder
       Region 4zse A 875-1007 order
       Region 4zse A 1008-1022 disorder
 Evidence X-RAY 5xgn B Reference
       Region 5xgn B 696-696 disorder
       Region 5xgn B 697-733 order
       Region 5xgn B 734-734 disorder
       Region 5xgn B 735-861 order
       Region 5xgn B 862-865 disorder
       Region 5xgn B 866-987 order
       Region 5xgn B 988-990 disorder
       Region 5xgn B 991-1002 order
       Region 5xgn B 1003-1009 disorder
       Region 5xgn B 1010-1019 order
       Region 5xgn B 1020-1022 disorder
 Evidence X-RAY 5xgn A Reference
       Region 5xgn A 696-696 disorder
       Region 5xgn A 697-988 order
       Region 5xgn A 989-1010 disorder
       Region 5xgn A 1011-1020 order
       Region 5xgn A 1021-1022 disorder
 Evidence X-RAY 5x2f C Reference
       Region 5x2f C 696-699 disorder
       Region 5x2f C 700-862 order
       Region 5x2f C 863-875 disorder
       Region 5x2f C 876-1014 order
       Region 5x2f C 1015-1022 disorder
 Evidence X-RAY 5x2f B Reference
       Region 5x2f B 696-698 disorder
       Region 5x2f B 699-1010 order
       Region 5x2f B 1011-1022 disorder
 Evidence X-RAY 5x2f D Reference
       Region 5x2f D 696-696 disorder
       Region 5x2f D 697-867 order
       Region 5x2f D 868-874 disorder
       Region 5x2f D 875-1006 order
       Region 5x2f D 1007-1008 disorder
       Region 5x2f D 1009-1014 order
       Region 5x2f D 1015-1022 disorder
 Evidence X-RAY 5x2f A Reference
       Region 5x2f A 696-699 disorder
       Region 5x2f A 700-862 order
       Region 5x2f A 863-874 disorder
       Region 5x2f A 875-1007 order
       Region 5x2f A 1008-1009 disorder
       Region 5x2f A 1010-1014 order
       Region 5x2f A 1015-1022 disorder
 Evidence X-RAY 5x2a C Reference
       Region 5x2a C 696-699 disorder
       Region 5x2a C 700-862 order
       Region 5x2a C 863-875 disorder
       Region 5x2a C 876-1015 order
       Region 5x2a C 1016-1022 disorder
 Evidence X-RAY 5x2a B Reference
       Region 5x2a B 696-699 disorder
       Region 5x2a B 700-987 order
       Region 5x2a B 988-988 disorder
       Region 5x2a B 989-1022 order
 Evidence X-RAY 5x2a D Reference
       Region 5x2a D 696-700 disorder
       Region 5x2a D 701-749 order
       Region 5x2a D 750-752 disorder
       Region 5x2a D 753-864 order
       Region 5x2a D 865-874 disorder
       Region 5x2a D 875-1005 order
       Region 5x2a D 1006-1009 disorder
       Region 5x2a D 1010-1014 order
       Region 5x2a D 1015-1022 disorder
 Evidence X-RAY 5x2a A Reference
       Region 5x2a A 696-699 disorder
       Region 5x2a A 700-862 order
       Region 5x2a A 863-875 disorder
       Region 5x2a A 876-1007 order
       Region 5x2a A 1008-1009 disorder
       Region 5x2a A 1010-1011 order
       Region 5x2a A 1012-1022 disorder
 Evidence X-RAY 3vjo A Reference
       Region 3vjo A 695-695 disorder
       Region 3vjo A 696-720 order
       Region 3vjo A 721-722 disorder
       Region 3vjo A 723-746 order
       Region 3vjo A 747-749 disorder
       Region 3vjo A 750-985 order
       Region 3vjo A 986-1005 disorder
       Region 3vjo A 1006-1018 order
       Region 3vjo A 1019-1022 disorder
 Evidence X-RAY 3vjn A Reference
       Region 3vjn A 695-696 disorder
       Region 3vjn A 697-720 order
       Region 3vjn A 721-723 disorder
       Region 3vjn A 724-747 order
       Region 3vjn A 748-748 disorder
       Region 3vjn A 749-984 order
       Region 3vjn A 985-1005 disorder
       Region 3vjn A 1006-1018 order
       Region 3vjn A 1019-1022 disorder
 Evidence X-RAY 3ug2 A Reference
       Region 3ug2 A 695-696 disorder
       Region 3ug2 A 697-720 order
       Region 3ug2 A 721-723 disorder
       Region 3ug2 A 724-746 order
       Region 3ug2 A 747-751 disorder
       Region 3ug2 A 752-989 order
       Region 3ug2 A 990-1004 disorder
       Region 3ug2 A 1005-1018 order
       Region 3ug2 A 1019-1022 disorder
 Evidence X-RAY 3ug1 A Reference
       Region 3ug1 A 695-696 disorder
       Region 3ug1 A 697-720 order
       Region 3ug1 A 721-723 disorder
       Region 3ug1 A 724-746 order
       Region 3ug1 A 747-751 disorder
       Region 3ug1 A 752-984 order
       Region 3ug1 A 985-1002 disorder
       Region 3ug1 A 1003-1018 order
       Region 3ug1 A 1019-1022 disorder
 Evidence X-RAY 4ll0 B Reference
       Region 4ll0 B 694-697 disorder
       Region 4ll0 B 698-861 order
       Region 4ll0 B 862-875 disorder
       Region 4ll0 B 876-985 order
       Region 4ll0 B 986-1010 disorder
       Region 4ll0 B 1011-1017 order
       Region 4ll0 B 1018-1022 disorder
 Evidence X-RAY 4ll0 A Reference
       Region 4ll0 A 694-696 disorder
       Region 4ll0 A 697-862 order
       Region 4ll0 A 863-875 disorder
       Region 4ll0 A 876-987 order
       Region 4ll0 A 988-1003 disorder
       Region 4ll0 A 1004-1008 order
       Region 4ll0 A 1009-1009 disorder
       Region 4ll0 A 1010-1017 order
       Region 4ll0 A 1018-1022 disorder
 Evidence X-RAY 4jrv A Reference
       Region 4jrv A 696-747 order
       Region 4jrv A 748-750 disorder
       Region 4jrv A 751-984 order
       Region 4jrv A 985-1005 disorder
       Region 4jrv A 1006-1019 order
       Region 4jrv A 1020-1021 disorder
 Evidence X-RAY 4jr3 A Reference
       Region 4jr3 A 696-984 order
       Region 4jr3 A 985-1005 disorder
       Region 4jr3 A 1006-1019 order
       Region 4jr3 A 1020-1021 disorder
 Evidence X-RAY 4jq8 A Reference
       Region 4jq8 A 696-984 order
       Region 4jq8 A 985-1005 disorder
       Region 4jq8 A 1006-1019 order
       Region 4jq8 A 1020-1021 disorder
 Evidence X-RAY 4jq7 A Reference
       Region 4jq7 A 696-984 order
       Region 4jq7 A 985-1005 disorder
       Region 4jq7 A 1006-1019 order
       Region 4jq7 A 1020-1021 disorder
 Evidence X-RAY 3gt8 D Reference
       Region 3gt8 D 696-700 disorder
       Region 3gt8 D 701-861 order
       Region 3gt8 D 862-876 disorder
       Region 3gt8 D 877-1010 order
       Region 3gt8 D 1011-1022 disorder
 Evidence X-RAY 3gt8 A Reference
       Region 3gt8 A 696-699 disorder
       Region 3gt8 A 700-861 order
       Region 3gt8 A 862-876 disorder
       Region 3gt8 A 877-1014 order
       Region 3gt8 A 1015-1022 disorder
 Evidence X-RAY 3gt8 C Reference
       Region 3gt8 C 696-698 disorder
       Region 3gt8 C 699-862 order
       Region 3gt8 C 863-875 disorder
       Region 3gt8 C 876-1007 order
       Region 3gt8 C 1008-1022 disorder
 Evidence X-RAY 3gt8 B Reference
       Region 3gt8 B 696-700 disorder
       Region 3gt8 B 701-861 order
       Region 3gt8 B 862-876 disorder
       Region 3gt8 B 877-1007 order
       Region 3gt8 B 1008-1022 disorder
 Evidence X-RAY 2gs7 B Reference
       Region 2gs7 B 696-700 disorder
       Region 2gs7 B 701-871 order
       Region 2gs7 B 872-874 disorder
       Region 2gs7 B 875-983 order
       Region 2gs7 B 984-1008 disorder
       Region 2gs7 B 1009-1016 order
       Region 2gs7 B 1017-1022 disorder
 Evidence X-RAY 2gs7 A Reference
       Region 2gs7 A 696-702 disorder
       Region 2gs7 A 703-870 order
       Region 2gs7 A 871-874 disorder
       Region 2gs7 A 875-983 order
       Region 2gs7 A 984-1008 disorder
       Region 2gs7 A 1009-1012 order
       Region 2gs7 A 1013-1022 disorder
 Evidence X-RAY 2gs2 A Reference
       Region 2gs2 A 696-746 order
       Region 2gs2 A 747-749 disorder
       Region 2gs2 A 750-990 order
       Region 2gs2 A 991-1005 disorder
       Region 2gs2 A 1006-1018 order
       Region 2gs2 A 1019-1022 disorder
 Evidence X-RAY 3gop A Reference
       Region 3gop A 669-675 disorder
       Region 3gop A 676-719 order
       Region 3gop A 720-723 disorder
       Region 3gop A 724-736 order
       Region 3gop A 737-737 disorder
       Region 3gop A 738-747 order
       Region 3gop A 748-753 disorder
       Region 3gop A 754-857 order
       Region 3gop A 858-875 disorder
       Region 3gop A 876-985 order
       Region 3gop A 986-993 disorder
       Region 3gop A 994-1002 order
       Region 3gop A 1003-1008 disorder
       Region 3gop A 1009-1018 order
       Region 3gop A 1019-1022 disorder
 Evidence X-RAY 2eb3 A Reference
       Region 2eb3 A 695-695 disorder
       Region 2eb3 A 696-720 order
       Region 2eb3 A 721-721 disorder
       Region 2eb3 A 722-861 order
       Region 2eb3 A 862-875 disorder
       Region 2eb3 A 876-990 order
       Region 2eb3 A 991-1004 disorder
       Region 2eb3 A 1005-1018 order
       Region 2eb3 A 1019-1022 disorder
 Evidence X-RAY 2eb2 A Reference
       Region 2eb2 A 695-695 disorder
       Region 2eb2 A 696-720 order
       Region 2eb2 A 721-723 disorder
       Region 2eb2 A 724-748 order
       Region 2eb2 A 749-749 disorder
       Region 2eb2 A 750-864 order
       Region 2eb2 A 865-865 disorder
       Region 2eb2 A 866-990 order
       Region 2eb2 A 991-1004 disorder
       Region 2eb2 A 1005-1019 order
       Region 2eb2 A 1020-1022 disorder
 Evidence X-RAY 5d41 B Reference
       Region 5d41 B 695-700 disorder
       Region 5d41 B 701-862 order
       Region 5d41 B 863-874 disorder
       Region 5d41 B 875-1014 order
       Region 5d41 B 1015-1022 disorder
 Evidence X-RAY 5d41 A Reference
       Region 5d41 A 695-697 disorder
       Region 5d41 A 698-858 order
       Region 5d41 A 859-875 disorder
       Region 5d41 A 876-1014 order
       Region 5d41 A 1015-1022 disorder
Seq 682-1022 Hetero dimer : P21860
 Evidence X-RAY 4riy D Reference
       Region 4riy D 682-687 disorder
       Region 4riy D 688-984 order
       Region 4riy D 985-1022 disorder
 Evidence X-RAY 4riy B Reference
       Region 4riy B 682-687 disorder
       Region 4riy B 688-871 order
       Region 4riy B 872-875 disorder
       Region 4riy B 876-984 order
       Region 4riy B 985-1022 disorder
 Evidence X-RAY 4rix D Reference
       Region 4rix D 682-687 disorder
       Region 4rix D 688-984 order
       Region 4rix D 985-1022 disorder
 Evidence X-RAY 4rix B Reference
       Region 4rix B 682-687 disorder
       Region 4rix B 688-871 order
       Region 4rix B 872-875 disorder
       Region 4rix B 876-984 order
       Region 4rix B 985-1022 disorder
 Evidence X-RAY 4riw D Reference
       Region 4riw D 682-687 disorder
       Region 4riw D 688-984 order
       Region 4riw D 985-1022 disorder
 Evidence X-RAY 4riw B Reference
       Region 4riw B 682-687 disorder
       Region 4riw B 688-871 order
       Region 4riw B 872-875 disorder
       Region 4riw B 876-984 order
       Region 4riw B 985-1022 disorder
Seq 694-1022 Hetero dimer :
 Evidence X-RAY 5czh A Reference
       Region 5czh A 694-695 disorder
       Region 5czh A 696-990 order
       Region 5czh A 991-1002 disorder
       Region 5czh A 1003-1018 order
       Region 5czh A 1019-1022 disorder
Seq 694-1022 Hetero dimer : IID00511Complex
 Evidence X-RAY 5czi A Reference
       Region 5czi A 694-695 disorder
       Region 5czi A 696-990 order
       Region 5czi A 991-1002 disorder
       Region 5czi A 1003-1004 order
       Region 5czi A 1005-1005 disorder
       Region 5czi A 1006-1018 order
       Region 5czi A 1019-1022 disorder
Seq 694-1042 Monomer :
 Evidence X-RAY 4zau A Reference
       Region 4zau A 696-697 disorder
       Region 4zau A 698-746 order
       Region 4zau A 747-755 disorder
       Region 4zau A 756-862 order
       Region 4zau A 863-865 disorder
       Region 4zau A 866-872 order
       Region 4zau A 873-874 disorder
       Region 4zau A 875-984 order
       Region 4zau A 985-1007 disorder
       Region 4zau A 1008-1017 order
       Region 4zau A 1018-1022 disorder
 Evidence X-RAY 5yu9 D Reference
       Region 5yu9 D 696-699 disorder
       Region 5yu9 D 700-862 order
       Region 5yu9 D 863-875 disorder
       Region 5yu9 D 876-1012 order
       Region 5yu9 D 1013-1022 disorder
 Evidence X-RAY 5yu9 C Reference
       Region 5yu9 C 696-696 disorder
       Region 5yu9 C 697-749 order
       Region 5yu9 C 750-753 disorder
       Region 5yu9 C 754-862 order
       Region 5yu9 C 863-874 disorder
       Region 5yu9 C 875-1007 order
       Region 5yu9 C 1008-1010 disorder
       Region 5yu9 C 1011-1021 order
       Region 5yu9 C 1022-1022 disorder
 Evidence X-RAY 5yu9 B Reference
       Region 5yu9 B 696-698 disorder
       Region 5yu9 B 699-749 order
       Region 5yu9 B 750-754 disorder
       Region 5yu9 B 755-862 order
       Region 5yu9 B 863-875 disorder
       Region 5yu9 B 876-1011 order
       Region 5yu9 B 1012-1022 disorder
 Evidence X-RAY 5yu9 A Reference
       Region 5yu9 A 696-699 disorder
       Region 5yu9 A 700-749 order
       Region 5yu9 A 750-753 disorder
       Region 5yu9 A 754-862 order
       Region 5yu9 A 863-874 disorder
       Region 5yu9 A 875-1017 order
       Region 5yu9 A 1018-1022 disorder
 Evidence X-RAY 1xkk A Reference
       Region 1xkk A 695-701 disorder
       Region 1xkk A 702-733 order
       Region 1xkk A 734-737 disorder
       Region 1xkk A 738-749 order
       Region 1xkk A 750-753 disorder
       Region 1xkk A 754-867 order
       Region 1xkk A 868-875 disorder
       Region 1xkk A 876-987 order
       Region 1xkk A 988-994 disorder
       Region 1xkk A 995-1004 order
       Region 1xkk A 1005-1009 disorder
       Region 1xkk A 1010-1018 order
       Region 1xkk A 1019-1022 disorder
 Evidence X-RAY 5xgm A Reference
       Region 5xgm A 696-722 order
       Region 5xgm A 723-723 disorder
       Region 5xgm A 724-748 order
       Region 5xgm A 749-751 disorder
       Region 5xgm A 752-858 order
       Region 5xgm A 859-874 disorder
       Region 5xgm A 875-987 order
       Region 5xgm A 988-988 disorder
       Region 5xgm A 989-990 order
       Region 5xgm A 991-1005 disorder
       Region 5xgm A 1006-1019 order
       Region 5xgm A 1020-1022 disorder
 Evidence X-RAY 5xdl A Reference
       Region 5xdl A 696-746 order
       Region 5xdl A 747-748 disorder
       Region 5xdl A 749-861 order
       Region 5xdl A 862-876 disorder
       Region 5xdl A 877-990 order
       Region 5xdl A 991-1004 disorder
       Region 5xdl A 1005-1018 order
       Region 5xdl A 1019-1022 disorder
 Evidence X-RAY 5xdk A Reference
       Region 5xdk A 696-748 order
       Region 5xdk A 749-749 disorder
       Region 5xdk A 750-990 order
       Region 5xdk A 991-1005 disorder
       Region 5xdk A 1006-1018 order
       Region 5xdk A 1019-1022 disorder
 Evidence X-RAY 5x2k A Reference
       Region 5x2k A 696-747 order
       Region 5x2k A 748-749 disorder
       Region 5x2k A 750-866 order
       Region 5x2k A 867-872 disorder
       Region 5x2k A 873-990 order
       Region 5x2k A 991-993 disorder
       Region 5x2k A 994-1020 order
       Region 5x2k A 1021-1022 disorder
 Evidence X-RAY 5x2c B Reference
       Region 5x2c B 696-700 disorder
       Region 5x2c B 701-863 order
       Region 5x2c B 864-874 disorder
       Region 5x2c B 875-1014 order
       Region 5x2c B 1015-1022 disorder
 Evidence X-RAY 5x2c A Reference
       Region 5x2c A 696-699 disorder
       Region 5x2c A 700-862 order
       Region 5x2c A 863-874 disorder
       Region 5x2c A 875-1015 order
       Region 5x2c A 1016-1022 disorder
 Evidence X-RAY 5x28 A Reference
       Region 5x28 A 696-696 disorder
       Region 5x28 A 697-866 order
       Region 5x28 A 867-875 disorder
       Region 5x28 A 876-992 order
       Region 5x28 A 993-997 disorder
       Region 5x28 A 998-1020 order
       Region 5x28 A 1021-1022 disorder
 Evidence X-RAY 5x27 A Reference
       Region 5x27 A 696-696 disorder
       Region 5x27 A 697-866 order
       Region 5x27 A 867-875 disorder
       Region 5x27 A 876-990 order
       Region 5x27 A 991-1003 disorder
       Region 5x27 A 1004-1020 order
       Region 5x27 A 1021-1022 disorder
 Evidence X-RAY 5x26 A Reference
       Region 5x26 A 696-696 disorder
       Region 5x26 A 697-866 order
       Region 5x26 A 867-875 disorder
       Region 5x26 A 876-990 order
       Region 5x26 A 991-1003 disorder
       Region 5x26 A 1004-1020 order
       Region 5x26 A 1021-1022 disorder
 Evidence X-RAY 4wrg A Reference
       Region 4wrg A 696-719 order
       Region 4wrg A 720-724 disorder
       Region 4wrg A 725-746 order
       Region 4wrg A 747-751 disorder
       Region 4wrg A 752-754 order
       Region 4wrg A 755-755 disorder
       Region 4wrg A 756-784 order
       Region 4wrg A 785-785 disorder
       Region 4wrg A 786-872 order
       Region 4wrg A 873-874 disorder
       Region 4wrg A 875-984 order
       Region 4wrg A 985-1006 disorder
       Region 4wrg A 1007-1019 order
       Region 4wrg A 1020-1022 disorder
 Evidence X-RAY 4wkq A Reference
       Region 4wkq A 696-720 order
       Region 4wkq A 721-723 disorder
       Region 4wkq A 724-746 order
       Region 4wkq A 747-751 disorder
       Region 4wkq A 752-984 order
       Region 4wkq A 985-1006 disorder
       Region 4wkq A 1007-1020 order
       Region 4wkq A 1021-1022 disorder
 Evidence X-RAY 4wd5 B Reference
       Region 4wd5 B 694-696 disorder
       Region 4wd5 B 697-861 order
       Region 4wd5 B 862-865 disorder
       Region 4wd5 B 866-867 order
       Region 4wd5 B 868-868 disorder
       Region 4wd5 B 869-987 order
       Region 4wd5 B 988-992 disorder
       Region 4wd5 B 993-1002 order
       Region 4wd5 B 1003-1008 disorder
       Region 4wd5 B 1009-1016 order
       Region 4wd5 B 1017-1022 disorder
 Evidence X-RAY 4wd5 A Reference
       Region 4wd5 A 694-987 order
       Region 4wd5 A 988-1008 disorder
       Region 4wd5 A 1009-1021 order
       Region 4wd5 A 1022-1022 disorder
 Evidence X-RAY 3w33 A Reference
       Region 3w33 A 696-700 disorder
       Region 3w33 A 701-748 order
       Region 3w33 A 749-753 disorder
       Region 3w33 A 754-862 order
       Region 3w33 A 863-874 disorder
       Region 3w33 A 875-1003 order
       Region 3w33 A 1004-1007 disorder
       Region 3w33 A 1008-1018 order
       Region 3w33 A 1019-1022 disorder
 Evidence X-RAY 3w32 A Reference
       Region 3w32 A 696-700 disorder
       Region 3w32 A 701-1017 order
       Region 3w32 A 1018-1022 disorder
 Evidence X-RAY 3w2s A Reference
       Region 3w2s A 696-700 disorder
       Region 3w2s A 701-862 order
       Region 3w2s A 863-874 disorder
       Region 3w2s A 875-1019 order
       Region 3w2s A 1020-1022 disorder
 Evidence X-RAY 3w2r A Reference
       Region 3w2r A 698-861 order
       Region 3w2r A 862-875 disorder
       Region 3w2r A 876-985 order
       Region 3w2r A 986-994 disorder
       Region 3w2r A 995-1017 order
       Region 3w2r A 1018-1022 disorder
 Evidence X-RAY 3w2q A Reference
       Region 3w2q A 698-992 order
       Region 3w2q A 993-1006 disorder
       Region 3w2q A 1007-1017 order
       Region 3w2q A 1018-1022 disorder
 Evidence X-RAY 3w2p A Reference
       Region 3w2p A 698-991 order
       Region 3w2p A 992-1005 disorder
       Region 3w2p A 1006-1018 order
       Region 3w2p A 1019-1022 disorder
 Evidence X-RAY 3w2o A Reference
       Region 3w2o A 698-990 order
       Region 3w2o A 991-1006 disorder
       Region 3w2o A 1007-1017 order
       Region 3w2o A 1018-1022 disorder
 Evidence X-RAY 5uwd A Reference
       Region 5uwd A 695-701 disorder
       Region 5uwd A 702-862 order
       Region 5uwd A 863-874 disorder
       Region 5uwd A 875-984 order
       Region 5uwd A 985-1022 disorder
 Evidence X-RAY 5ugc A Reference
       Region 5ugc A 695-701 disorder
       Region 5ugc A 702-748 order
       Region 5ugc A 749-752 disorder
       Region 5ugc A 753-985 order
       Region 5ugc A 986-1022 disorder
 Evidence X-RAY 5ugb A Reference
       Region 5ugb A 695-747 order
       Region 5ugb A 748-749 disorder
       Region 5ugb A 750-990 order
       Region 5ugb A 991-1005 disorder
       Region 5ugb A 1006-1018 order
       Region 5ugb A 1019-1022 disorder
 Evidence X-RAY 5uga A Reference
       Region 5uga A 695-702 disorder
       Region 5uga A 703-985 order
       Region 5uga A 986-1022 disorder
 Evidence X-RAY 5ug9 A Reference
       Region 5ug9 A 695-701 disorder
       Region 5ug9 A 702-748 order
       Region 5ug9 A 749-752 disorder
       Region 5ug9 A 753-985 order
       Region 5ug9 A 986-1022 disorder
 Evidence X-RAY 5ug8 A Reference
       Region 5ug8 A 695-701 disorder
       Region 5ug8 A 702-748 order
       Region 5ug8 A 749-752 disorder
       Region 5ug8 A 753-985 order
       Region 5ug8 A 986-1022 disorder
 Evidence X-RAY 5u8l A Reference
       Region 5u8l A 695-701 disorder
       Region 5u8l A 702-990 order
       Region 5u8l A 991-1022 disorder
 Evidence X-RAY 4tks A Reference
       Region 4tks A 695-696 disorder
       Region 4tks A 697-747 order
       Region 4tks A 748-750 disorder
       Region 4tks A 751-990 order
       Region 4tks A 991-1003 disorder
       Region 4tks A 1004-1019 order
       Region 4tks A 1020-1022 disorder
 Evidence X-RAY 4rj8 A Reference
       Region 4rj8 A 695-696 disorder
       Region 4rj8 A 697-747 order
       Region 4rj8 A 748-751 disorder
       Region 4rj8 A 752-861 order
       Region 4rj8 A 862-875 disorder
       Region 4rj8 A 876-998 order
       Region 4rj8 A 999-1004 disorder
       Region 4rj8 A 1005-1018 order
       Region 4rj8 A 1019-1022 disorder
 Evidence X-RAY 4rj7 A Reference
       Region 4rj7 A 695-696 disorder
       Region 4rj7 A 697-746 order
       Region 4rj7 A 747-751 disorder
       Region 4rj7 A 752-861 order
       Region 4rj7 A 862-875 disorder
       Region 4rj7 A 876-997 order
       Region 4rj7 A 998-1005 disorder
       Region 4rj7 A 1006-1018 order
       Region 4rj7 A 1019-1022 disorder
 Evidence X-RAY 4rj6 A Reference
       Region 4rj6 A 695-696 disorder
       Region 4rj6 A 697-746 order
       Region 4rj6 A 747-750 disorder
       Region 4rj6 A 751-861 order
       Region 4rj6 A 862-875 disorder
       Region 4rj6 A 876-998 order
       Region 4rj6 A 999-1005 disorder
       Region 4rj6 A 1006-1018 order
       Region 4rj6 A 1019-1022 disorder
 Evidence X-RAY 4rj5 A Reference
       Region 4rj5 A 695-696 disorder
       Region 4rj5 A 697-746 order
       Region 4rj5 A 747-750 disorder
       Region 4rj5 A 751-859 order
       Region 4rj5 A 860-875 disorder
       Region 4rj5 A 876-998 order
       Region 4rj5 A 999-1005 disorder
       Region 4rj5 A 1006-1019 order
       Region 4rj5 A 1020-1022 disorder
 Evidence X-RAY 4rj4 A Reference
       Region 4rj4 A 695-696 disorder
       Region 4rj4 A 697-746 order
       Region 4rj4 A 747-749 disorder
       Region 4rj4 A 750-861 order
       Region 4rj4 A 862-875 disorder
       Region 4rj4 A 876-998 order
       Region 4rj4 A 999-1004 disorder
       Region 4rj4 A 1005-1018 order
       Region 4rj4 A 1019-1022 disorder
 Evidence X-RAY 2rgp A Reference
       Region 2rgp A 702-733 order
       Region 2rgp A 734-737 disorder
       Region 2rgp A 738-748 order
       Region 2rgp A 749-753 disorder
       Region 2rgp A 754-867 order
       Region 2rgp A 868-875 disorder
       Region 2rgp A 876-987 order
       Region 2rgp A 988-995 disorder
       Region 2rgp A 996-1003 order
       Region 2rgp A 1004-1009 disorder
       Region 2rgp A 1010-1016 order
 Evidence X-RAY 4r5s A Reference
       Region 4r5s A 696-696 disorder
       Region 4r5s A 697-866 order
       Region 4r5s A 867-875 disorder
       Region 4r5s A 876-990 order
       Region 4r5s A 991-1004 disorder
       Region 4r5s A 1005-1018 order
       Region 4r5s A 1019-1022 disorder
 Evidence X-RAY 3poz A Reference
       Region 3poz A 696-700 disorder
       Region 3poz A 701-733 order
       Region 3poz A 734-737 disorder
       Region 3poz A 738-747 order
       Region 3poz A 748-754 disorder
       Region 3poz A 755-867 order
       Region 3poz A 868-874 disorder
       Region 3poz A 875-1003 order
       Region 3poz A 1004-1009 disorder
       Region 3poz A 1010-1017 order
       Region 3poz A 1018-1022 disorder
 Evidence X-RAY 1m17 A Reference
       Region 1m17 A 695-695 disorder
       Region 1m17 A 696-988 order
       Region 1m17 A 989-1000 disorder
       Region 1m17 A 1001-1019 order
       Region 1m17 A 1020-1022 disorder
 Evidence X-RAY 1m14 A Reference
       Region 1m14 A 695-695 disorder
       Region 1m14 A 696-984 order
       Region 1m14 A 985-1002 disorder
       Region 1m14 A 1003-1020 order
       Region 1m14 A 1021-1022 disorder
 Evidence X-RAY 4lrm E Reference
       Region 4lrm E 694-696 disorder
       Region 4lrm E 697-983 order
       Region 4lrm E 984-1022 disorder
 Evidence X-RAY 4lrm D Reference
       Region 4lrm D 694-695 disorder
       Region 4lrm D 696-981 order
       Region 4lrm D 982-1022 disorder
 Evidence X-RAY 4lrm C Reference
       Region 4lrm C 694-983 order
       Region 4lrm C 984-1022 disorder
 Evidence X-RAY 4lrm B Reference
       Region 4lrm B 694-694 disorder
       Region 4lrm B 695-984 order
       Region 4lrm B 985-1022 disorder
 Evidence X-RAY 4lrm A Reference
       Region 4lrm A 694-695 disorder
       Region 4lrm A 696-999 order
       Region 4lrm A 1000-1022 disorder
 Evidence X-RAY 4lqm A Reference
       Region 4lqm A 694-696 disorder
       Region 4lqm A 697-747 order
       Region 4lqm A 748-750 disorder
       Region 4lqm A 751-866 order
       Region 4lqm A 867-873 disorder
       Region 4lqm A 874-991 order
       Region 4lqm A 992-999 disorder
       Region 4lqm A 1000-1019 order
       Region 4lqm A 1020-1022 disorder
 Evidence X-RAY 4li5 A Reference
       Region 4li5 A 696-985 order
       Region 4li5 A 986-1007 disorder
       Region 4li5 A 1008-1020 order
 Evidence X-RAY 2jiv B Reference
       Region 2jiv B 695-698 disorder
       Region 2jiv B 699-753 order
       Region 2jiv B 754-754 disorder
       Region 2jiv B 755-861 order
       Region 2jiv B 862-872 disorder
       Region 2jiv B 873-982 order
       Region 2jiv B 983-1022 disorder
 Evidence X-RAY 2jiv A Reference
       Region 2jiv A 695-699 disorder
       Region 2jiv A 700-753 order
       Region 2jiv A 754-754 disorder
       Region 2jiv A 755-860 order
       Region 2jiv A 861-874 disorder
       Region 2jiv A 875-984 order
       Region 2jiv A 985-1022 disorder
 Evidence X-RAY 5jeb A Reference
       Region 5jeb A 696-698 disorder
       Region 5jeb A 699-748 order
       Region 5jeb A 749-750 disorder
       Region 5jeb A 751-999 order
       Region 5jeb A 1000-1022 disorder
 Evidence X-RAY 5j9z A Reference
       Region 5j9z A 696-860 order
       Region 5j9z A 861-875 disorder
       Region 5j9z A 876-987 order
       Region 5j9z A 988-1006 disorder
       Region 5j9z A 1007-1020 order
 Evidence X-RAY 5j9y A Reference
       Region 5j9y A 697-862 order
       Region 5j9y A 863-865 disorder
       Region 5j9y A 866-985 order
       Region 5j9y A 986-1005 disorder
       Region 5j9y A 1006-1019 order
 Evidence X-RAY 2j6m A Reference
       Region 2j6m A 696-696 disorder
       Region 2j6m A 697-984 order
       Region 2j6m A 985-1002 disorder
       Region 2j6m A 1003-1020 order
       Region 2j6m A 1021-1022 disorder
 Evidence X-RAY 2j5f A Reference
       Region 2j5f A 696-866 order
       Region 2j5f A 867-874 disorder
       Region 2j5f A 875-992 order
       Region 2j5f A 993-1000 disorder
       Region 2j5f A 1001-1019 order
       Region 2j5f A 1020-1022 disorder
 Evidence X-RAY 2j5e A Reference
       Region 2j5e A 696-985 order
       Region 2j5e A 986-986 disorder
       Region 2j5e A 987-990 order
       Region 2j5e A 991-1004 disorder
       Region 2j5e A 1005-1020 order
       Region 2j5e A 1021-1022 disorder
 Evidence X-RAY 2itz A Reference
       Region 2itz A 696-696 disorder
       Region 2itz A 697-865 order
       Region 2itz A 866-875 disorder
       Region 2itz A 876-990 order
       Region 2itz A 991-1001 disorder
       Region 2itz A 1002-1019 order
       Region 2itz A 1020-1022 disorder
 Evidence X-RAY 2ity A Reference
       Region 2ity A 696-696 disorder
       Region 2ity A 697-865 order
       Region 2ity A 866-875 disorder
       Region 2ity A 876-989 order
       Region 2ity A 990-1002 disorder
       Region 2ity A 1003-1019 order
       Region 2ity A 1020-1022 disorder
 Evidence X-RAY 2itx A Reference
       Region 2itx A 696-696 disorder
       Region 2itx A 697-861 order
       Region 2itx A 862-865 disorder
       Region 2itx A 866-989 order
       Region 2itx A 990-1001 disorder
       Region 2itx A 1002-1019 order
       Region 2itx A 1020-1022 disorder
 Evidence X-RAY 2itw A Reference
       Region 2itw A 696-984 order
       Region 2itw A 985-1006 disorder
       Region 2itw A 1007-1017 order
       Region 2itw A 1018-1022 disorder
 Evidence X-RAY 2itv A Reference
       Region 2itv A 696-866 order
       Region 2itv A 867-875 disorder
       Region 2itv A 876-989 order
       Region 2itv A 990-1001 disorder
       Region 2itv A 1002-1019 order
       Region 2itv A 1020-1022 disorder
 Evidence X-RAY 2itu A Reference
       Region 2itu A 696-865 order
       Region 2itu A 866-875 disorder
       Region 2itu A 876-991 order
       Region 2itu A 992-1001 disorder
       Region 2itu A 1002-1019 order
       Region 2itu A 1020-1022 disorder
 Evidence X-RAY 2itt A Reference
       Region 2itt A 696-696 disorder
       Region 2itt A 697-866 order
       Region 2itt A 867-875 disorder
       Region 2itt A 876-989 order
       Region 2itt A 990-1001 disorder
       Region 2itt A 1002-1019 order
       Region 2itt A 1020-1022 disorder
 Evidence X-RAY 2itq A Reference
       Region 2itq A 696-696 disorder
       Region 2itq A 697-984 order
       Region 2itq A 985-1006 disorder
       Region 2itq A 1007-1018 order
       Region 2itq A 1019-1022 disorder
 Evidence X-RAY 2itp A Reference
       Region 2itp A 696-696 disorder
       Region 2itp A 697-984 order
       Region 2itp A 985-1001 disorder
       Region 2itp A 1002-1018 order
       Region 2itp A 1019-1022 disorder
 Evidence X-RAY 2ito A Reference
       Region 2ito A 696-866 order
       Region 2ito A 867-875 disorder
       Region 2ito A 876-989 order
       Region 2ito A 990-1001 disorder
       Region 2ito A 1002-1019 order
       Region 2ito A 1020-1022 disorder
 Evidence X-RAY 2itn A Reference
       Region 2itn A 696-866 order
       Region 2itn A 867-875 disorder
       Region 2itn A 876-989 order
       Region 2itn A 990-1000 disorder
       Region 2itn A 1001-1019 order
       Region 2itn A 1020-1022 disorder
 Evidence X-RAY 3ika B Reference
       Region 3ika B 694-696 disorder
       Region 3ika B 697-861 order
       Region 3ika B 862-863 disorder
       Region 3ika B 864-987 order
       Region 3ika B 988-992 disorder
       Region 3ika B 993-1005 order
       Region 3ika B 1006-1009 disorder
       Region 3ika B 1010-1017 order
       Region 3ika B 1018-1022 disorder
 Evidence X-RAY 3ika A Reference
       Region 3ika A 694-695 disorder
       Region 3ika A 696-988 order
       Region 3ika A 989-1003 disorder
       Region 3ika A 1004-1020 order
       Region 3ika A 1021-1022 disorder
 Evidence X-RAY 4i24 B Reference
       Region 4i24 B 695-699 disorder
       Region 4i24 B 700-862 order
       Region 4i24 B 863-873 disorder
       Region 4i24 B 874-1014 order
       Region 4i24 B 1015-1022 disorder
 Evidence X-RAY 4i24 A Reference
       Region 4i24 A 695-699 disorder
       Region 4i24 A 700-747 order
       Region 4i24 A 748-754 disorder
       Region 4i24 A 755-862 order
       Region 4i24 A 863-875 disorder
       Region 4i24 A 876-1014 order
       Region 4i24 A 1015-1022 disorder
 Evidence X-RAY 4i23 A Reference
       Region 4i23 A 695-720 order
       Region 4i23 A 721-723 disorder
       Region 4i23 A 724-747 order
       Region 4i23 A 748-749 disorder
       Region 4i23 A 750-990 order
       Region 4i23 A 991-1005 disorder
       Region 4i23 A 1006-1018 order
       Region 4i23 A 1019-1022 disorder
 Evidence X-RAY 4i22 A Reference
       Region 4i22 A 695-699 disorder
       Region 4i22 A 700-748 order
       Region 4i22 A 749-753 disorder
       Region 4i22 A 754-862 order
       Region 4i22 A 863-875 disorder
       Region 4i22 A 876-1014 order
       Region 4i22 A 1015-1022 disorder
 Evidence X-RAY 4i20 A Reference
       Region 4i20 A 695-700 disorder
       Region 4i20 A 701-987 order
       Region 4i20 A 988-1022 disorder
 Evidence X-RAY 4i1z A Reference
       Region 4i1z A 695-700 disorder
       Region 4i1z A 701-987 order
       Region 4i1z A 988-1022 disorder
 Evidence X-RAY 4hjo A Reference
       Region 4hjo A 696-702 disorder
       Region 4hjo A 703-733 order
       Region 4hjo A 734-737 disorder
       Region 4hjo A 738-984 order
       Region 4hjo A 985-1022 disorder
 Evidence X-RAY 5hic A Reference
       Region 5hic A 695-696 disorder
       Region 5hic A 697-747 order
       Region 5hic A 748-749 disorder
       Region 5hic A 750-861 order
       Region 5hic A 862-875 disorder
       Region 5hic A 876-998 order
       Region 5hic A 999-1003 disorder
       Region 5hic A 1004-1019 order
       Region 5hic A 1020-1022 disorder
 Evidence X-RAY 5hib A Reference
       Region 5hib A 695-695 disorder
       Region 5hib A 696-862 order
       Region 5hib A 863-867 disorder
       Region 5hib A 868-1001 order
       Region 5hib A 1002-1005 disorder
       Region 5hib A 1006-1018 order
       Region 5hib A 1019-1022 disorder
 Evidence X-RAY 5hg9 A Reference
       Region 5hg9 A 695-701 disorder
       Region 5hg9 A 702-748 order
       Region 5hg9 A 749-752 disorder
       Region 5hg9 A 753-985 order
       Region 5hg9 A 986-1022 disorder
 Evidence X-RAY 5hg8 A Reference
       Region 5hg8 A 695-699 disorder
       Region 5hg8 A 700-999 order
       Region 5hg8 A 1000-1022 disorder
 Evidence X-RAY 5hg7 A Reference
       Region 5hg7 A 695-701 disorder
       Region 5hg7 A 702-748 order
       Region 5hg7 A 749-751 disorder
       Region 5hg7 A 752-984 order
       Region 5hg7 A 985-1022 disorder
 Evidence X-RAY 5hg5 A Reference
       Region 5hg5 A 695-699 disorder
       Region 5hg5 A 700-1001 order
       Region 5hg5 A 1002-1022 disorder
 Evidence X-RAY 5hcz A Reference
       Region 5hcz A 696-747 order
       Region 5hcz A 748-750 disorder
       Region 5hcz A 751-861 order
       Region 5hcz A 862-875 disorder
       Region 5hcz A 876-998 order
       Region 5hcz A 999-1005 disorder
       Region 5hcz A 1006-1019 order
       Region 5hcz A 1020-1022 disorder
 Evidence X-RAY 5hcy A Reference
       Region 5hcy A 696-747 order
       Region 5hcy A 748-749 disorder
       Region 5hcy A 750-862 order
       Region 5hcy A 863-875 disorder
       Region 5hcy A 876-998 order
       Region 5hcy A 999-1005 disorder
       Region 5hcy A 1006-1019 order
       Region 5hcy A 1020-1022 disorder
 Evidence X-RAY 5hcx A Reference
       Region 5hcx A 696-747 order
       Region 5hcx A 748-750 disorder
       Region 5hcx A 751-861 order
       Region 5hcx A 862-875 disorder
       Region 5hcx A 876-997 order
       Region 5hcx A 998-1005 disorder
       Region 5hcx A 1006-1018 order
       Region 5hcx A 1019-1022 disorder
 Evidence X-RAY 5gtz A Reference
       Region 5gtz A 696-696 disorder
       Region 5gtz A 697-867 order
       Region 5gtz A 868-874 disorder
       Region 5gtz A 875-1020 order
       Region 5gtz A 1021-1022 disorder
 Evidence X-RAY 5gnk A Reference
       Region 5gnk A 696-696 disorder
       Region 5gnk A 697-863 order
       Region 5gnk A 864-875 disorder
       Region 5gnk A 876-985 order
       Region 5gnk A 986-988 disorder
 Evidence X-RAY 5gmp A Reference
       Region 5gmp A 696-864 order
       Region 5gmp A 865-875 disorder
       Region 5gmp A 876-990 order
       Region 5gmp A 991-998 disorder
       Region 5gmp A 999-1019 order
       Region 5gmp A 1020-1022 disorder
 Evidence X-RAY 4g5p B Reference
       Region 4g5p B 696-696 disorder
       Region 4g5p B 697-861 order
       Region 4g5p B 862-866 disorder
       Region 4g5p B 867-871 order
       Region 4g5p B 872-874 disorder
       Region 4g5p B 875-985 order
       Region 4g5p B 986-988 disorder
       Region 4g5p B 989-990 order
       Region 4g5p B 991-992 disorder
       Region 4g5p B 993-1003 order
       Region 4g5p B 1004-1009 disorder
       Region 4g5p B 1010-1018 order
       Region 4g5p B 1019-1022 disorder
 Evidence X-RAY 4g5p A Reference
       Region 4g5p A 696-986 order
       Region 4g5p A 987-1008 disorder
       Region 4g5p A 1009-1016 order
       Region 4g5p A 1017-1022 disorder
 Evidence X-RAY 4g5j A Reference
       Region 4g5j A 696-720 order
       Region 4g5j A 721-724 disorder
       Region 4g5j A 725-746 order
       Region 4g5j A 747-756 disorder
       Region 4g5j A 757-1016 order
       Region 4g5j A 1017-1022 disorder
 Evidence X-RAY 5feq A Reference
       Region 5feq A 696-696 disorder
       Region 5feq A 697-746 order
       Region 5feq A 747-751 disorder
       Region 5feq A 752-864 order
       Region 5feq A 865-867 disorder
       Region 5feq A 868-871 order
       Region 5feq A 872-873 disorder
       Region 5feq A 874-985 order
       Region 5feq A 986-1006 disorder
       Region 5feq A 1007-1017 order
       Region 5feq A 1018-1022 disorder
 Evidence X-RAY 5fee A Reference
       Region 5fee A 696-696 disorder
       Region 5fee A 697-720 order
       Region 5fee A 721-724 disorder
       Region 5fee A 725-746 order
       Region 5fee A 747-751 disorder
       Region 5fee A 752-862 order
       Region 5fee A 863-867 disorder
       Region 5fee A 868-985 order
       Region 5fee A 986-1006 disorder
       Region 5fee A 1007-1018 order
       Region 5fee A 1019-1022 disorder
 Evidence X-RAY 5fed A Reference
       Region 5fed A 696-696 disorder
       Region 5fed A 697-720 order
       Region 5fed A 721-723 disorder
       Region 5fed A 724-746 order
       Region 5fed A 747-751 disorder
       Region 5fed A 752-862 order
       Region 5fed A 863-866 disorder
       Region 5fed A 867-985 order
       Region 5fed A 986-1006 disorder
       Region 5fed A 1007-1017 order
       Region 5fed A 1018-1022 disorder
 Evidence X-RAY 5em8 A Reference
       Region 5em8 A 695-695 disorder
       Region 5em8 A 696-746 order
       Region 5em8 A 747-749 disorder
       Region 5em8 A 750-864 order
       Region 5em8 A 865-866 disorder
       Region 5em8 A 867-990 order
       Region 5em8 A 991-1005 disorder
       Region 5em8 A 1006-1018 order
       Region 5em8 A 1019-1022 disorder
 Evidence X-RAY 5em7 A Reference
       Region 5em7 A 695-695 disorder
       Region 5em7 A 696-746 order
       Region 5em7 A 747-749 disorder
       Region 5em7 A 750-861 order
       Region 5em7 A 862-875 disorder
       Region 5em7 A 876-998 order
       Region 5em7 A 999-1005 disorder
       Region 5em7 A 1006-1019 order
       Region 5em7 A 1020-1022 disorder
 Evidence X-RAY 5em6 A Reference
       Region 5em6 A 695-696 disorder
       Region 5em6 A 697-747 order
       Region 5em6 A 748-750 disorder
       Region 5em6 A 751-861 order
       Region 5em6 A 862-875 disorder
       Region 5em6 A 876-998 order
       Region 5em6 A 999-1003 disorder
       Region 5em6 A 1004-1019 order
       Region 5em6 A 1020-1022 disorder
 Evidence X-RAY 5em5 A Reference
       Region 5em5 A 695-696 disorder
       Region 5em5 A 697-746 order
       Region 5em5 A 747-750 disorder
       Region 5em5 A 751-859 order
       Region 5em5 A 860-875 disorder
       Region 5em5 A 876-998 order
       Region 5em5 A 999-1003 disorder
       Region 5em5 A 1004-1019 order
       Region 5em5 A 1020-1022 disorder
 Evidence X-RAY 5edr A Reference
       Region 5edr A 695-696 disorder
       Region 5edr A 697-747 order
       Region 5edr A 748-749 disorder
       Region 5edr A 750-859 order
       Region 5edr A 860-875 disorder
       Region 5edr A 876-998 order
       Region 5edr A 999-1003 disorder
       Region 5edr A 1004-1018 order
       Region 5edr A 1019-1022 disorder
 Evidence X-RAY 5edq A Reference
       Region 5edq A 695-696 disorder
       Region 5edq A 697-859 order
       Region 5edq A 860-875 disorder
       Region 5edq A 876-997 order
       Region 5edq A 998-1005 disorder
       Region 5edq A 1006-1018 order
       Region 5edq A 1019-1022 disorder
 Evidence X-RAY 5edp A Reference
       Region 5edp A 695-696 disorder
       Region 5edp A 697-747 order
       Region 5edp A 748-749 disorder
       Region 5edp A 750-859 order
       Region 5edp A 860-874 disorder
       Region 5edp A 875-997 order
       Region 5edp A 998-1007 disorder
       Region 5edp A 1008-1018 order
       Region 5edp A 1019-1022 disorder
 Evidence X-RAY 5cnn B Reference
       Region 5cnn B 696-699 disorder
       Region 5cnn B 700-863 order
       Region 5cnn B 864-874 disorder
       Region 5cnn B 875-1014 order
       Region 5cnn B 1015-1042 disorder
 Evidence X-RAY 5cnn A Reference
       Region 5cnn A 696-698 disorder
       Region 5cnn A 699-750 order
       Region 5cnn A 751-753 disorder
       Region 5cnn A 754-861 order
       Region 5cnn A 862-874 disorder
       Region 5cnn A 875-1014 order
       Region 5cnn A 1015-1042 disorder
 Evidence X-RAY 5cav A Reference
       Region 5cav A 695-696 disorder
       Region 5cav A 697-984 order
       Region 5cav A 985-1002 disorder
       Region 5cav A 1003-1020 order
       Region 5cav A 1021-1022 disorder
 Evidence X-RAY 5cau A Reference
       Region 5cau A 695-695 disorder
       Region 5cau A 696-747 order
       Region 5cau A 748-751 disorder
       Region 5cau A 752-861 order
       Region 5cau A 862-875 disorder
       Region 5cau A 876-998 order
       Region 5cau A 999-1006 disorder
       Region 5cau A 1007-1018 order
       Region 5cau A 1019-1022 disorder
 Evidence X-RAY 5cas A Reference
       Region 5cas A 695-695 disorder
       Region 5cas A 696-747 order
       Region 5cas A 748-751 disorder
       Region 5cas A 752-862 order
       Region 5cas A 863-875 disorder
       Region 5cas A 876-998 order
       Region 5cas A 999-1006 disorder
       Region 5cas A 1007-1019 order
       Region 5cas A 1020-1022 disorder
 Evidence X-RAY 5caq A Reference
       Region 5caq A 695-696 disorder
       Region 5caq A 697-747 order
       Region 5caq A 748-749 disorder
       Region 5caq A 750-861 order
       Region 5caq A 862-875 disorder
       Region 5caq A 876-998 order
       Region 5caq A 999-1003 disorder
       Region 5caq A 1004-1018 order
       Region 5caq A 1019-1022 disorder
 Evidence X-RAY 5cap A Reference
       Region 5cap A 695-696 disorder
       Region 5cap A 697-860 order
       Region 5cap A 861-875 disorder
       Region 5cap A 876-1000 order
       Region 5cap A 1001-1005 disorder
       Region 5cap A 1006-1019 order
       Region 5cap A 1020-1022 disorder
 Evidence X-RAY 5cao A Reference
       Region 5cao A 695-696 disorder
       Region 5cao A 697-747 order
       Region 5cao A 748-750 disorder
       Region 5cao A 751-859 order
       Region 5cao A 860-875 disorder
       Region 5cao A 876-999 order
       Region 5cao A 1000-1003 disorder
       Region 5cao A 1004-1019 order
       Region 5cao A 1020-1022 disorder
 Evidence X-RAY 5can A Reference
       Region 5can A 695-695 disorder
       Region 5can A 696-747 order
       Region 5can A 748-749 disorder
       Region 5can A 750-861 order
       Region 5can A 862-875 disorder
       Region 5can A 876-998 order
       Region 5can A 999-1005 disorder
       Region 5can A 1006-1019 order
       Region 5can A 1020-1022 disorder
 Evidence X-RAY 5cal A Reference
       Region 5cal A 695-696 disorder
       Region 5cal A 697-747 order
       Region 5cal A 748-749 disorder
       Region 5cal A 750-860 order
       Region 5cal A 861-875 disorder
       Region 5cal A 876-998 order
       Region 5cal A 999-1003 disorder
       Region 5cal A 1004-1018 order
       Region 5cal A 1019-1022 disorder
 Evidence X-RAY 5c8n A Reference
       Region 5c8n A 695-695 disorder
       Region 5c8n A 696-747 order
       Region 5c8n A 748-750 disorder
       Region 5c8n A 751-861 order
       Region 5c8n A 862-875 disorder
       Region 5c8n A 876-998 order
       Region 5c8n A 999-1005 disorder
       Region 5c8n A 1006-1019 order
       Region 5c8n A 1020-1022 disorder
 Evidence X-RAY 5c8m A Reference
       Region 5c8m A 695-696 disorder
       Region 5c8m A 697-747 order
       Region 5c8m A 748-749 disorder
       Region 5c8m A 750-861 order
       Region 5c8m A 862-875 disorder
       Region 5c8m A 876-998 order
       Region 5c8m A 999-1003 disorder
       Region 5c8m A 1004-1019 order
       Region 5c8m A 1020-1022 disorder
 Evidence X-RAY 5c8k A Reference
       Region 5c8k A 695-696 disorder
       Region 5c8k A 697-747 order
       Region 5c8k A 748-749 disorder
       Region 5c8k A 750-860 order
       Region 5c8k A 861-875 disorder
       Region 5c8k A 876-998 order
       Region 5c8k A 999-1003 disorder
       Region 5c8k A 1004-1018 order
       Region 5c8k A 1019-1022 disorder
 Evidence X-RAY 3bel A Reference
       Region 3bel A 702-733 order
       Region 3bel A 734-737 disorder
       Region 3bel A 738-747 order
       Region 3bel A 748-753 disorder
       Region 3bel A 754-867 order
       Region 3bel A 868-875 disorder
       Region 3bel A 876-986 order
       Region 3bel A 987-995 disorder
       Region 3bel A 996-1002 order
       Region 3bel A 1003-1009 disorder
       Region 3bel A 1010-1015 order
       Region 3bel A 1016-1016 disorder
Seq 695-1022 Hetero dimer : IID00286Complex
 Evidence X-RAY 2rf9 B Reference
       Region 2rf9 B 696-700 disorder
       Region 2rf9 B 701-734 order
       Region 2rf9 B 735-738 disorder
       Region 2rf9 B 739-748 order
       Region 2rf9 B 749-754 disorder
       Region 2rf9 B 755-863 order
       Region 2rf9 B 864-867 disorder
       Region 2rf9 B 868-871 order
       Region 2rf9 B 872-873 disorder
       Region 2rf9 B 874-985 order
       Region 2rf9 B 986-1022 disorder
 Evidence X-RAY 2rf9 A Reference
       Region 2rf9 A 696-698 disorder
       Region 2rf9 A 699-749 order
       Region 2rf9 A 750-752 disorder
       Region 2rf9 A 753-871 order
       Region 2rf9 A 872-873 disorder
       Region 2rf9 A 874-983 order
       Region 2rf9 A 984-1022 disorder
 Evidence X-RAY 4i21 B Reference
       Region 4i21 B 695-702 disorder
       Region 4i21 B 703-993 order
       Region 4i21 B 994-1009 disorder
       Region 4i21 B 1010-1020 order
       Region 4i21 B 1021-1022 disorder
 Evidence X-RAY 4i21 A Reference
       Region 4i21 A 695-702 disorder
       Region 4i21 A 703-987 order
       Region 4i21 A 988-1014 disorder
       Region 4i21 A 1015-1019 order
       Region 4i21 A 1020-1022 disorder
Seq 695-1022 Hetero dimer : IID00286Complex
 Evidence X-RAY 4zjv B Reference
       Region 4zjv B 695-702 disorder
       Region 4zjv B 703-733 order
       Region 4zjv B 734-737 disorder
       Region 4zjv B 738-747 order
       Region 4zjv B 748-750 disorder
       Region 4zjv B 751-982 order
       Region 4zjv B 983-1022 disorder
 Evidence X-RAY 4zjv A Reference
       Region 4zjv A 695-702 disorder
       Region 4zjv A 703-736 order
       Region 4zjv A 737-737 disorder
       Region 4zjv A 738-985 order
       Region 4zjv A 986-1022 disorder
Seq 696-1018 Hetero dimer : IID00286Complex
 Evidence X-RAY 4r3r A Reference
       Region 4r3r A 696-748 order
       Region 4r3r A 749-749 disorder
       Region 4r3r A 750-990 order
       Region 4r3r A 991-1002 disorder
       Region 4r3r A 1003-1004 order
       Region 4r3r A 1005-1005 disorder
       Region 4r3r A 1006-1018 order
 Evidence X-RAY 4r3p A Reference
       Region 4r3p A 696-990 order
       Region 4r3p A 991-1002 disorder
       Region 4r3p A 1003-1004 order
       Region 4r3p A 1005-1005 disorder
       Region 4r3p A 1006-1018 order
Seq 696-1022 Hetero tetramer :
 Evidence X-RAY 2gs6 A Reference
       Region 2gs6 A 696-747 order
       Region 2gs6 A 748-750 disorder
       Region 2gs6 A 751-991 order
       Region 2gs6 A 992-1004 disorder
       Region 2gs6 A 1005-1019 order
       Region 2gs6 A 1020-1022 disorder
Seq 696-1022 Homo tetramer :
 Evidence X-RAY 5gty G Reference
       Region 5gty G 696-698 disorder
       Region 5gty G 699-749 order
       Region 5gty G 750-754 disorder
       Region 5gty G 755-862 order
       Region 5gty G 863-874 disorder
       Region 5gty G 875-1014 order
       Region 5gty G 1015-1022 disorder
 Evidence X-RAY 5gty F Reference
       Region 5gty F 696-699 disorder
       Region 5gty F 700-749 order
       Region 5gty F 750-753 disorder
       Region 5gty F 754-862 order
       Region 5gty F 863-875 disorder
       Region 5gty F 876-1013 order
       Region 5gty F 1014-1022 disorder
 Evidence X-RAY 5gty D Reference
       Region 5gty D 696-700 disorder
       Region 5gty D 701-749 order
       Region 5gty D 750-754 disorder
       Region 5gty D 755-862 order
       Region 5gty D 863-874 disorder
       Region 5gty D 875-1014 order
       Region 5gty D 1015-1022 disorder
 Evidence X-RAY 5gty B Reference
       Region 5gty B 696-699 disorder
       Region 5gty B 700-749 order
       Region 5gty B 750-753 disorder
       Region 5gty B 754-862 order
       Region 5gty B 863-874 disorder
       Region 5gty B 875-1014 order
       Region 5gty B 1015-1022 disorder
 Evidence X-RAY 5gty H Reference
       Region 5gty H 696-699 disorder
       Region 5gty H 700-750 order
       Region 5gty H 751-754 disorder
       Region 5gty H 755-862 order
       Region 5gty H 863-874 disorder
       Region 5gty H 875-1011 order
       Region 5gty H 1012-1012 disorder
       Region 5gty H 1013-1016 order
       Region 5gty H 1017-1022 disorder
 Evidence X-RAY 5gty E Reference
       Region 5gty E 696-700 disorder
       Region 5gty E 701-749 order
       Region 5gty E 750-754 disorder
       Region 5gty E 755-862 order
       Region 5gty E 863-874 disorder
       Region 5gty E 875-1014 order
       Region 5gty E 1015-1022 disorder
 Evidence X-RAY 5gty C Reference
       Region 5gty C 696-699 disorder
       Region 5gty C 700-749 order
       Region 5gty C 750-753 disorder
       Region 5gty C 754-861 order
       Region 5gty C 862-876 disorder
       Region 5gty C 877-1013 order
       Region 5gty C 1014-1022 disorder
 Evidence X-RAY 5gty A Reference
       Region 5gty A 696-699 disorder
       Region 5gty A 700-749 order
       Region 5gty A 750-753 disorder
       Region 5gty A 754-863 order
       Region 5gty A 864-874 disorder
       Region 5gty A 875-1014 order
       Region 5gty A 1015-1022 disorder
Seq 696-1022 Hetero trimer :
 Evidence X-RAY 5cno X Reference
       Region 5cno X 696-1012 disorder
       Region 5cno X 1013-1022 order
 Evidence X-RAY 5cno B Reference
       Region 5cno B 696-697 disorder
       Region 5cno B 698-749 order
       Region 5cno B 750-753 disorder
       Region 5cno B 754-862 order
       Region 5cno B 863-874 disorder
       Region 5cno B 875-1015 order
       Region 5cno B 1016-1022 disorder
 Evidence X-RAY 5cno A Reference
       Region 5cno A 696-699 disorder
       Region 5cno A 700-749 order
       Region 5cno A 750-754 disorder
       Region 5cno A 755-863 order
       Region 5cno A 864-874 disorder
       Region 5cno A 875-1015 order
       Region 5cno A 1016-1022 disorder
Seq 702-1022 Hetero dimer : IID00286Complex
 Evidence X-RAY 2rfd B Reference
       Region 2rfd B 702-702 disorder
       Region 2rfd B 703-749 order
       Region 2rfd B 750-753 disorder
       Region 2rfd B 754-865 order
       Region 2rfd B 866-873 disorder
       Region 2rfd B 874-990 order
       Region 2rfd B 991-1008 disorder
       Region 2rfd B 1009-1018 order
       Region 2rfd B 1019-1022 disorder
 Evidence X-RAY 2rfd A Reference
       Region 2rfd A 702-702 disorder
       Region 2rfd A 703-749 order
       Region 2rfd A 750-752 disorder
       Region 2rfd A 753-863 order
       Region 2rfd A 864-874 disorder
       Region 2rfd A 875-990 order
       Region 2rfd A 991-1004 disorder
       Region 2rfd A 1005-1018 order
       Region 2rfd A 1019-1022 disorder
Seq 702-1022 Hetero hexamer : IID00286Complex
 Evidence X-RAY 2rfe A Reference
       Region 2rfe A 702-866 order
       Region 2rfe A 867-874 disorder
       Region 2rfe A 875-983 order
       Region 2rfe A 984-991 disorder
       Region 2rfe A 992-1002 order
       Region 2rfe A 1003-1022 disorder
 Evidence X-RAY 2rfe B Reference
       Region 2rfe B 702-702 disorder
       Region 2rfe B 703-863 order
       Region 2rfe B 864-874 disorder
       Region 2rfe B 875-983 order
       Region 2rfe B 984-1009 disorder
       Region 2rfe B 1010-1012 order
       Region 2rfe B 1013-1022 disorder
 Evidence X-RAY 2rfe C Reference
       Region 2rfe C 702-733 order
       Region 2rfe C 734-739 disorder
       Region 2rfe C 740-748 order
       Region 2rfe C 749-751 disorder
       Region 2rfe C 752-863 order
       Region 2rfe C 864-874 disorder
       Region 2rfe C 875-983 order
       Region 2rfe C 984-1022 disorder
 Evidence X-RAY 2rfe D Reference
       Region 2rfe D 702-702 disorder
       Region 2rfe D 703-748 order
       Region 2rfe D 749-751 disorder
       Region 2rfe D 752-863 order
       Region 2rfe D 864-874 disorder
       Region 2rfe D 875-983 order
       Region 2rfe D 984-1007 disorder
       Region 2rfe D 1008-1018 order
       Region 2rfe D 1019-1022 disorder
Seq 1062-1074 Hetero dimer : IID00287Complex
 Evidence X-RAY 3vrr C Reference
       Region 3vrr C 1062-1066 disorder
       Region 3vrr C 1067-1074 order
 Evidence X-RAY 3vrp B Reference
       Region 3vrp B 1062-1066 disorder
       Region 3vrp B 1067-1074 order
Seq 1063-1075 Hetero dimer : IID00300Complex
 Evidence X-RAY 3ob2 A Reference
       Region 3ob2 A 1063-1063 disorder
       Region 3ob2 A 1064-1074 order
 Evidence X-RAY 3buo C Reference
       Region 3buo C 1063-1063 disorder
       Region 3buo C 1064-1074 order
       Region 3buo C 1075-1075 disorder
 Evidence X-RAY 3buo A Reference
       Region 3buo A 1063-1063 disorder
       Region 3buo A 1064-1074 order
       Region 3buo A 1075-1075 disorder
Seq 1066-1076 Hetero tetramer : IID00287Complex
 Evidence X-RAY 3op0 C Reference
       Region 3op0 C 1066-1075 order
       Region 3op0 C 1076-1076 disorder
 Evidence X-RAY 3op0 D Reference
       Region 3op0 D 1066-1075 order
       Region 3op0 D 1076-1076 disorder
Seq 1066-1076 Hetero tetramer : IID00319Complex
 Evidence X-RAY 3pfv C Reference
       Region 3pfv C 1066-1075 order
       Region 3pfv C 1076-1076 disorder
 Evidence X-RAY 3pfv D Reference
       Region 3pfv D 1066-1076 order
SeqProS verified 669-688 Homo dimer :
       Region 2m20 A 642-697 order
       Region 1z9i A 669-696 disorder
SeqProS possible 991-1007 This region is described to be disordered in the active state (PubMed=19563760). Homo dimer :
       Region 3gt8 A 877-1014 order
       Region 3gt8 B 877-1007 order
       Region 3gt8 C 876-1007 order
       Region 3gt8 D 877-1010 order
Seqphosphorylation
    1197-1197 Phosphotyrosine; by autocatalysis
    1172-1172 Phosphotyrosine; by autocatalysis
    1166-1166 Phosphoserine
    1110-1110 Phosphotyrosine; by autocatalysis
    1092-1092 Phosphotyrosine; by autocatalysis
    1081-1081 Phosphoserine
    1071-1071 Phosphoserine
    1070-1070 Phosphoserine
    1069-1069 Phosphotyrosine
    1064-1064 Phosphoserine
    1042-1042 Phosphoserine
    1041-1041 Phosphothreonine
    1039-1039 Phosphoserine
    1026-1026 Phosphoserine
    1016-1016 Phosphotyrosine; by autocatalysis
    998-998 Phosphotyrosine; by autocatalysis
    995-995 Phosphoserine
    991-991 Phosphoserine
    869-869 Phosphotyrosine
    695-695 Phosphoserine
    693-693 Phosphothreonine; by PKD/PRKD1
    678-678 Phosphothreonine; by PKC and PKD/PRKD1
    229-229 Phosphoserine
 
Prediction
NeProc
Disorder 1-26,628-645,669-686,989-1210
Order 27-627,646-668,687-988
ProS 8-22,628-645,669-686,996-1005,1014-1018,1031-1077,1083-1087,1104-1116,1122-1142,1149-1159,1165-1178,1184-1210
AlphaFold
Disorder 1-26,41-41,182-185,638-655,673-704,721-723,735-735,737-737,748-759,761-762,856-875,985-1210
Order 27-40,42-181,186-637,656-672,705-720,724-734,736-736,738-747,760-760,763-855,876-984
Pfam Hmmer
PF01030 57-168 2.6e-42
PF00757 184-338 2.2e-101
PF01030 361-481 1.6e-43
PF07714 712-968 1.1e-128
SEG 7-25 ,651-666 ,675-692 ,1002-1015 ,1025-1046
Function
Function in SwissProt
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704, PubMed:17909029). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity).
Isoform 2 may act as an antagonist of EGF action.
(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins.
Biological Process
Diagram with PDB data
EGFR/CBLCrystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor'
See also
Diagram with PDB data
ERRFI1/EGFRcrystal structure of EGFR kinase domain in complex with Mitogen-inducible gene 6 protein
ERRFI1/EGFRCrystal structure of the complex between the EGFR kinase domain and a Mig6 peptide