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IID00267
 UniprotP11532
ProteinDystrophin
GeneDMD
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
3685
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-246 Homo tetramer :
 Evidence X-RAY 1dxx D Reference
       Region 1dxx D 1-8 disorder
       Region 1dxx D 9-246 order
 Evidence X-RAY 1dxx C Reference
       Region 1dxx C 1-8 disorder
       Region 1dxx C 9-246 order
 Evidence X-RAY 1dxx B Reference
       Region 1dxx B 1-8 disorder
       Region 1dxx B 9-246 order
 Evidence X-RAY 1dxx A Reference
       Region 1dxx A 1-8 disorder
       Region 1dxx A 9-246 order
Seq 338-456 Monomer :
 Evidence X-RAY 3uun B Reference
       Region 3uun B 338-338 disorder
       Region 3uun B 339-452 order
       Region 3uun B 453-456 disorder
 Evidence X-RAY 3uun A Reference
       Region 3uun A 338-453 order
       Region 3uun A 454-456 disorder
Seq 3046-3306 Hetero dimer : IID00278Complex
 Evidence X-RAY 1eg4 A Reference
       Region 1eg4 A 3046-3046 disorder
       Region 1eg4 A 3047-3306 order
Seq 3046-3306 Monomer :
 Evidence X-RAY 1eg3 A Reference
       Region 1eg3 A 3046-3046 disorder
       Region 1eg3 A 3047-3306 order
Seqphosphorylation
    348-348 Phosphoserine
    519-519 Phosphothreonine
    629-629 Phosphothreonine
    340-340 Phosphothreonine
    344-344 Phosphoserine
    348-348 Phosphoserine
    616-616 Phosphothreonine
    340-340 Phosphothreonine
    344-344 Phosphoserine
    3666-3666 Phosphoserine
    3623-3623 Phosphoserine
    3624-3624 Phosphoserine
    3617-3617 Phosphoserine
    3613-3613 Phosphoserine
    3500-3500 Phosphoserine
    3612-3612 Phosphoserine
    3483-3483 Phosphoserine
    3490-3490 Phosphoserine
 
Prediction
NeProc
Disorder 130-133,245-336,478-481,677-705,747-755,860-863,896-901,967-971,1186-1189,1292-1299,1599-1604,1805-1816,1947-1952,2353-2358,2425-2469,2720-2725,2881-2888,3419-3495,3538-3559,3604-3685
Order 1-129,134-244,337-410,417-477,482-520,525-631,637-676,711-746,756-790,797-855,864-895,902-966,972-1185,1190-1227,1233-1291,1300-1598,1605-1642,1647-1804,1817-1946,1953-1988,1997-2131,2137-2279,2285-2352,2363-2424,2470-2605,2610-2719,2726-2765,2771-2880,2889-3418,3496-3537,3560-3603
ProS 245-253,267-280,683-694,896-901,967-971,1186-1189,1299-1299,1805-1816,1947-1952,2720-2725,3431-3481,3490-3495,3555-3559,3604-3609,3640-3675,3682-3685
Pfam Hmmer
PF00307 16-119 2.1e-29
PF00307 135-240 1.6e-27
PF00435 339-447 3.3e-22
PF00435 448-556 6.8e-18
PF00435 830-934 7.2e-09
PF00435 1048-1154 2.3e-23
PF00435 1157-1263 1.1e-16
PF00435 1571-1676 1.3e-13
PF00435 1679-1780 7.9e-13
PF00435 1877-1979 3.2e-11
PF00435 2104-2208 1.7e-20
PF00435 2211-2318 3.7e-17
PF00435 2580-2686 1.4e-14
PF00435 2689-2802 0.0005
PF00435 2934-3040 2.9e-21
PF00397 3057-3086 1.5e-11
PF00569 3307-3352 6.9e-25
SEG 43-62 ,465-486 ,670-690 ,704-708 ,979-1000 ,1198-1215 ,2238-2262 ,2321-2344 ,2438-2451 ,2810-2823 ,3118-3134 ,3494-3510 ,3536-3553
Function
Function in SwissProt
Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.