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IID00269
 UniprotP42768
ProteinWiskott-Aldrich syndrome protein
GeneWAS
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
502
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 230-288 Hetero dimer : IID00308Complex
 Evidence NMR 1cee B Reference
       Region 1cee B 230-288 order
Seq 242-310 Hetero dimer : IID90008Complex
 Evidence NMR 2k42 A Reference
       Region 2k42 A 242-310 order
       Region 2k42 A 242-244 high_rmsd
Seq 242-310,461-492 Monomer :
 Evidence NMR 1ej5 A Reference
       Region 1ej5 A 242-310 order
       Region 1ej5 A 461-492 order
Seq 242-310,461-492 Monomer :
 Evidence NMR 1t84 A Reference
       Region 1t84 A 242-310 order
       Region 1t84 A 242-248 high_rmsd
       Region 1t84 A 461-492 order
       Region 1t84 A 461-462 high_rmsd
       Region 1t84 A 481-492 high_rmsd
Seq 430-458 Hetero trimer : IID50082Complex
 Evidence X-RAY 2a3z C Reference
       Region 2a3z C 430-430 disorder
       Region 2a3z C 431-447 order
       Region 2a3z C 448-458 disorder
Seqdisorder 230-310,461-492
 Evidence NMR¸ CD Reference
       Region 230-310 disorder
       Region 461-492 disorder
Seq 488-502 Hetero octamer : P00883
 Evidence X-RAY 2ot0 H Reference
       Region 2ot0 H 488-497 disorder
       Region 2ot0 H 498-501 order
       Region 2ot0 H 502-502 disorder
 Evidence X-RAY 2ot0 G Reference
       Region 2ot0 G 488-497 disorder
       Region 2ot0 G 498-501 order
       Region 2ot0 G 502-502 disorder
 Evidence X-RAY 2ot0 F Reference
       Region 2ot0 F 488-497 disorder
       Region 2ot0 F 498-501 order
       Region 2ot0 F 502-502 disorder
 Evidence X-RAY 2ot0 E Reference
       Region 2ot0 E 488-497 disorder
       Region 2ot0 E 498-501 order
       Region 2ot0 E 502-502 disorder
SeqProS verified 230-288 Hetero dimer : IID00308Complex
       Region 1cee B 230-288 order
       Region 230-310 disorder
SeqProS verified 242-310 Hetero dimer : IID90008Complex
       Region 2k42 A 242-310 order
       Region 230-310 disorder
SeqProS verified 242-310,461-492 This region takes an ordered structure when it binds upon another region of this protein, which inhibits the binding upon Cdc42. :
       Region 1ej5 A 242-310 order
       Region 1ej5 A 461-492 order
       Region 230-310 disorder
       Region 461-492 disorder
SeqProS verified 242-310,461-492 This region takes an ordered structure when it binds upon another region of this protein, which inhibits the binding upon Cdc42. :
       Region 1t84 A 242-310 order
       Region 1t84 A 461-492 order
       Region 230-310 disorder
       Region 461-492 disorder
SeqProS possible 431-447 This region is described to be disordered in the free state. (PubMed=10724160) Hetero trimer : IID50082Complex
       Region 2a3z C 431-447 order
Seqphosphorylation
    484-484 Phosphoserine; by CK2
    483-483 Phosphoserine; by CK2
    291-291 Phosphotyrosine; by FYN and HCK
    221-221 Phosphoserine
 
Prediction
NeProc
Disorder 1-23,147-242,303-502
Order 24-146,244-302
ProS 19-23,157-160,188-195,230-242,433-443,463-483,495-502
AlphaFold
Disorder 1-18,153-231,238-238,244-249,310-342,344-351,354-358,360-360,362-365,373-384,386-393,395-395,401-432,441-441,443-464,482-502
Order 19-152,232-237,239-243,250-309,343-343,352-353,359-359,361-361,366-372,385-385,394-394,396-400,433-440,442-442,465-481
Pfam Hmmer
PF00568 39-145 8.9e-63
PF00786 237-296 5.7e-18
PF02205 430-447 3.4e-06
SEG 3-17 ,172-197 ,225-235 ,312-319 ,340-435 ,485-502
Function
Function in SwissProt
Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:8625410, PubMed:12235133, PubMed:16275905). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).