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IID00272
 UniprotP49450
ProteinHistone H3-like centromeric protein A
GeneCENPA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
140
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-140 Hetero trimer : IID00058Complex,IID00283Complex
 Evidence X-RAY 3r45 A Reference
       Region 3r45 A 1-58 disorder
       Region 3r45 A 59-140 order
Seq 1-140 Hetero tetramer : IID00058Complex
 Evidence X-RAY 3nqu A Reference
       Region 3nqu A 1-58 disorder
       Region 3nqu A 59-134 order
       Region 3nqu A 135-140 disorder
 Evidence X-RAY 3nqj A Reference
       Region 3nqj A 60-134 order
       Region 3nqj A 135-140 disorder
Seq 1-140 Hetero octamer : IID00016Complex,IID00058Complex
 Evidence X-RAY 3an2 E Reference
       Region 3an2 E 1-47 disorder
       Region 3an2 E 48-78 order
       Region 3an2 E 79-83 disorder
       Region 3an2 E 84-135 order
       Region 3an2 E 136-140 disorder
 Evidence X-RAY 3an2 A Reference
       Region 3an2 A 1-45 disorder
       Region 3an2 A 46-134 order
       Region 3an2 A 135-140 disorder
Seq 1-140 Hetero octamer : IID00016Complex,IID00058Complex,IID00239Complex
 Evidence X-RAY 3wtp A Reference
       Region 3wtp A 1-45 disorder
       Region 3wtp A 46-134 order
       Region 3wtp A 135-140 disorder
Seq 3-10 Hetero dimer : Q9BV86
 Evidence X-RAY 5cvd E Reference
       Region 5cvd E 3-8 order
       Region 5cvd E 9-10 disorder
 Evidence X-RAY 5cvd D Reference
       Region 5cvd D 3-7 order
       Region 5cvd D 8-10 disorder
Seqphosphorylation
    7-7 Phosphoserine; by AURKA and AURKB
    17-17 Phosphoserine
    19-19 Phosphoserine
    68-68 Phosphoserine
    27-27 Phosphoserine
 
Prediction
NeProc
Disorder 1-45
Order 46-140
ProS 42-45
AlphaFold
Disorder 1-44,137-140
Order 45-136
Pfam Hmmer
PF00125 57-133 2.8e-33
SEG 3-37 ,87-100
Function
Function in SwissProt
Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:7962047, PubMed:9024683, PubMed:11756469, PubMed:14667408, PubMed:15702419, PubMed:15475964, PubMed:15282608, PubMed:17651496, PubMed:19114591, PubMed:27499292, PubMed:20739937). Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:27499292, PubMed:26878239). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15475964, PubMed:15282608, PubMed:26878239, PubMed:20739937, PubMed:21478274). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292).