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IID00275
 UniprotP83916
ProteinChromobox protein homolog 1
GeneCBX1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
185
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 20-73 Monomer :
 Evidence X-RAY 3f2u A Reference
       Region 3f2u A 20-69 order
       Region 3f2u A 70-73 disorder
Seq 104-175 Hetero decamer : IID00281Complex
 Evidence X-RAY 2fmm D Reference
       Region 2fmm D 104-109 disorder
       Region 2fmm D 110-175 order
 Evidence X-RAY 2fmm C Reference
       Region 2fmm C 104-108 disorder
       Region 2fmm C 109-175 order
 Evidence X-RAY 2fmm B Reference
       Region 2fmm B 104-108 disorder
       Region 2fmm B 109-175 order
 Evidence X-RAY 2fmm A Reference
       Region 2fmm A 104-107 disorder
       Region 2fmm A 108-175 order
Seq 108-185 Hetero dimer : IID00062Complex
 Evidence X-RAY 5t1g A Reference
       Region 5t1g A 108-168 order
       Region 5t1g A 169-185 disorder
Seq 108-185 Hetero trimer : Q5FBB7
 Evidence X-RAY 3q6s C Reference
       Region 3q6s C 108-109 disorder
       Region 3q6s C 110-173 order
       Region 3q6s C 174-185 disorder
 Evidence X-RAY 3q6s B Reference
       Region 3q6s B 108-108 disorder
       Region 3q6s B 109-175 order
       Region 3q6s B 176-185 disorder
 Evidence X-RAY 3q6s D Reference
       Region 3q6s D 108-109 disorder
       Region 3q6s D 110-174 order
       Region 3q6s D 175-185 disorder
 Evidence X-RAY 3q6s A Reference
       Region 3q6s A 108-108 disorder
       Region 3q6s A 109-174 order
       Region 3q6s A 175-185 disorder
Seqphosphorylation
    175-175 Phosphoserine
    91-91 Phosphoserine
    89-89 Phosphoserine
 
Prediction
NeProc
Disorder 1-19,75-110,175-185
Order 20-74,111-174
ProS 75-78,84-110
AlphaFold
Disorder 1-19,73-109,175-185
Order 20-72,110-174
Pfam Hmmer
PF00385 21-70 1.1e-23
PF01393 115-172 3.9e-40
SEG 3-26 ,86-109
Function
Function in SwissProt
Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.