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IID00279
 UniprotQ14155
ProteinRho guanine nucleotide exchange factor 7
GeneARHGEF7
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
803
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-84,106-137 Monomer :
 Evidence NMR 2l3g A Reference
       Region 2l3g A 1-84 order
       Region 2l3g A 106-137 order
Seq 179-243 Hetero dimer : IID00277Complex
 Evidence NMR 1zsg A Reference
       Region 1zsg A 179-243 order
       Region 1zsg A 179-184 high_rmsd
       Region 1zsg A 243-243 high_rmsd
Seq 183-243 Hetero trimer : IID00178Complex
 Evidence X-RAY 5sxp D Reference
       Region 5sxp D 183-183 disorder
       Region 5sxp D 184-243 order
 Evidence X-RAY 5sxp B Reference
       Region 5sxp B 183-243 order
 Evidence X-RAY 5sxp C Reference
       Region 5sxp C 183-183 disorder
       Region 5sxp C 184-243 order
 Evidence X-RAY 5sxp A Reference
       Region 5sxp A 183-243 order
Seq 260-467 Monomer :
 Evidence NMR 1by1 A Reference
       Region 1by1 A 260-467 order
Seqphosphorylation
    153-153 Phosphoserine
    664-664 Phosphoserine
    645-645 Phosphoserine
    579-579 Phosphoserine
    560-560 Phosphoserine
    176-176 Phosphoserine
    249-249 Phosphoserine
    257-257 Phosphoserine
    518-518 Phosphoserine
    694-694 Phosphoserine; by CaMK1
Seqacetylation
    2-2 N-acetylthreonine
    1-1 N-acetylmethionine
    2-2 N-acetylthreonine
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-4,63-183,245-267,581-711,729-773,789-803
Order 5-62,184-244,268-580,712-728,774-788
ProS 63-80,104-134,140-156,171-178,629-670,679-698,703-711,729-756,789-803
AlphaFold
Disorder 1-1,21-21,78-106,131-186,243-270,578-706,720-720,723-803
Order 2-20,22-77,107-130,187-242,271-577,707-719,721-722
Pfam Hmmer
PF00307 2-133 4.4e-05
PF00018 187-241 1.2e-24
PF00621 275-450 4.8e-22
PF00169 480-578 4.3e-15
SEG 621-635 ,651-668 ,681-693 ,752-778
Function
Function in SwissProt
Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.