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IID00283
 UniprotQ8NCD3
ProteinHolliday junction recognition protein
GeneHJURP
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
748
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-80 Hetero trimer : IID00058Complex,IID00272Complex
 Evidence X-RAY 3r45 C Reference
       Region 3r45 C 1-13 disorder
       Region 3r45 C 14-74 order
       Region 3r45 C 75-80 disorder
Seqphosphorylation
    123-123 Phosphoserine
    140-140 Phosphoserine
    185-185 Phosphoserine
    201-201 Phosphoserine
    211-211 Phosphoserine
    473-473 Phosphoserine
    412-412 Phosphoserine
    448-448 Phosphoserine
    642-642 Phosphoserine
    595-595 Phosphoserine
    496-496 Phosphoserine
    486-486 Phosphoserine; by PKB/AKT1
 
Prediction
NeProc
Disorder 1-14,73-125,180-251,277-397,402-748
Order 15-72,126-179,252-276,398-401
ProS 1-10,73-125,186-204,213-251,280-314,334-380,385-397,402-449,454-469,476-488,498-517,529-553,559-594,605-635,643-652,660-677,682-699,713-748
AlphaFold
Disorder 1-12,43-46,75-142,160-257,279-401,407-407,409-428,446-574,593-748
Order 13-42,47-74,143-159,258-278,402-406,408-408,429-445,575-592
SEG 20-35 ,179-191 ,233-247 ,276-287 ,485-500 ,518-523
Function
Function in SwissProt
Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.