Search Keyword:


Search option:


IID00285
 UniprotQ9UI95
ProteinMitotic spindle assembly checkpoint protein MAD2B
GeneMAD2L2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
211
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-211 Hetero dimer : Q96JM3
 Evidence X-RAY 5xpt A Reference
       Region 5xpt A 1-5 disorder
       Region 5xpt A 6-155 order
       Region 5xpt A 156-162 disorder
       Region 5xpt A 163-209 order
       Region 5xpt A 210-211 disorder
Seq 1-211 Hetero dimer : IID00259Complex
 Evidence X-RAY 3abd A Reference
       Region 3abd A 1-11 disorder
       Region 3abd A 12-106 order
       Region 3abd A 107-112 disorder
       Region 3abd A 113-153 order
       Region 3abd A 154-167 disorder
       Region 3abd A 168-211 order
 Evidence X-RAY 3abd B Reference
       Region 3abd B 1-9 disorder
       Region 3abd B 10-153 order
       Region 3abd B 154-160 disorder
       Region 3abd B 161-211 order
 Evidence X-RAY 3abe C Reference
       Region 3abe C 1-10 disorder
       Region 3abe C 11-105 order
       Region 3abe C 106-109 disorder
       Region 3abe C 110-210 order
       Region 3abe C 211-211 disorder
Seq 1-211 Hetero trimer : IID00259Complex,IID00284Complex
 Evidence X-RAY 3vu7 C Reference
       Region 3vu7 C 1-9 disorder
       Region 3vu7 C 10-106 order
       Region 3vu7 C 107-109 disorder
       Region 3vu7 C 110-208 order
       Region 3vu7 C 209-211 disorder
 Evidence X-RAY 4ext C Reference
       Region 4ext C 7-105 order
       Region 4ext C 106-111 disorder
       Region 4ext C 112-209 order
Seq 1-211 Hetero tetramer : Q96JM3
 Evidence X-RAY 5xpu A Reference
       Region 5xpu A 1-11 disorder
       Region 5xpu A 12-103 order
       Region 5xpu A 104-109 disorder
       Region 5xpu A 110-155 order
       Region 5xpu A 156-164 disorder
       Region 5xpu A 165-205 order
       Region 5xpu A 206-211 disorder
Seq 1-211 Hetero tetramer : IID00259Complex,IID00284Complex
 Evidence X-RAY 4gk5 A Reference
       Region 4gk5 A 1-8 disorder
       Region 4gk5 A 9-106 order
       Region 4gk5 A 107-109 disorder
       Region 4gk5 A 110-209 order
       Region 4gk5 A 210-211 disorder
Seq 1-211 Hetero trimer : IID00259Complex,IID00284Complex
 Evidence X-RAY 4gk0 A Reference
       Region 4gk0 A 1-8 disorder
       Region 4gk0 A 9-106 order
       Region 4gk0 A 107-109 disorder
       Region 4gk0 A 110-209 order
       Region 4gk0 A 210-211 disorder
 Evidence X-RAY 4gk0 B Reference
       Region 4gk0 B 1-9 disorder
       Region 4gk0 B 10-104 order
       Region 4gk0 B 105-113 disorder
       Region 4gk0 B 114-208 order
       Region 4gk0 B 209-211 disorder
 Evidence X-RAY 4gk5 B Reference
       Region 4gk5 B 1-9 disorder
       Region 4gk5 B 10-104 order
       Region 4gk5 B 105-113 disorder
       Region 4gk5 B 114-208 order
       Region 4gk5 B 209-211 disorder
 
Prediction
NeProc
Disorder 1-7,208-211
Order 8-207
AlphaFold
Disorder 1-9,107-113,210-211
Order 10-106,114-209
Pfam Hmmer
PF02301 11-200 4.1e-68
SEG 107-117
Function
Function in SwissProt
Adapter protein able to interact with different proteins and involved in different biological processes (PubMed:11459825, PubMed:11459826, PubMed:17719540, PubMed:17296730, PubMed:19443654, PubMed:29656893). Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis (PubMed:20164194). Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions (PubMed:20164194). Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1 (PubMed:17296730). Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle (PubMed:11459825, PubMed:17719540). Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation (PubMed:19443654).