Search Keyword:


Search option:


IID00286
 UniprotQ9UJM3
ProteinERBB receptor feedback inhibitor 1
GeneERRFI1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
462
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 315-374 Hetero dimer : IID00262Complex
 Evidence X-RAY 2rf9 C Reference
       Region 2rf9 C 315-335 disorder
       Region 2rf9 C 336-362 order
       Region 2rf9 C 363-374 disorder
 Evidence X-RAY 2rf9 D Reference
       Region 2rf9 D 315-336 disorder
       Region 2rf9 D 337-362 order
       Region 2rf9 D 363-374 disorder
 Evidence X-RAY 4i21 C Reference
       Region 4i21 C 315-334 disorder
       Region 4i21 C 335-364 order
       Region 4i21 C 365-374 disorder
 Evidence X-RAY 4i21 D Reference
       Region 4i21 D 315-336 disorder
       Region 4i21 D 337-362 order
       Region 4i21 D 363-374 disorder
Seq 325-364 Hetero hexamer : IID00262Complex
 Evidence X-RAY 2rfe E Reference
       Region 2rfe E 325-336 disorder
       Region 2rfe E 337-362 order
       Region 2rfe E 363-364 disorder
 Evidence X-RAY 2rfe F Reference
       Region 2rfe F 325-336 disorder
       Region 2rfe F 337-360 order
       Region 2rfe F 361-364 disorder
Seq 330-399 Hetero dimer : IID00262Complex
 Evidence X-RAY 4zjv C Reference
       Region 4zjv C 330-335 disorder
       Region 4zjv C 336-361 order
       Region 4zjv C 362-375 disorder
       Region 4zjv C 376-386 order
       Region 4zjv C 387-387 disorder
       Region 4zjv C 388-398 order
       Region 4zjv C 399-399 disorder
 Evidence X-RAY 4zjv D Reference
       Region 4zjv D 330-336 disorder
       Region 4zjv D 337-362 order
       Region 4zjv D 363-375 disorder
       Region 4zjv D 376-382 order
       Region 4zjv D 383-388 disorder
       Region 4zjv D 389-399 order
Seq 340-364 Hetero dimer : IID00262Complex
 Evidence X-RAY 2rfd C Reference
       Region 2rfd C 340-345 disorder
       Region 2rfd C 346-361 order
       Region 2rfd C 362-364 disorder
 Evidence X-RAY 2rfd D Reference
       Region 2rfd D 340-345 disorder
       Region 2rfd D 346-360 order
       Region 2rfd D 361-364 disorder
Seq 392-398 Hetero dimer : IID00262Complex
 Evidence X-RAY 4r3p B Reference
       Region 4r3p B 392-398 order
 Evidence X-RAY 4r3r B Reference
       Region 4r3r B 392-398 order
Seqphosphorylation
    302-302 Phosphoserine
    461-461 Phosphoserine
    273-273 Phosphoserine
    251-251 Phosphoserine
    131-131 Phosphothreonine
    127-127 Phosphothreonine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 38-376,414-462
Order 1-37,377-413
ProS 38-54,74-82,109-129,140-151,159-183,191-214,310-317,355-361,424-429,443-462
AlphaFold
Disorder 1-2,4-150,158-206,208-283,286-286,289-289,293-314,324-335,363-374,417-462
Order 3-3,151-157,207-207,284-285,287-288,290-292,315-323,336-362,375-416
SEG 86-103 ,227-241 ,280-296
Function
Function in SwissProt
Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity).
Biological Process
Diagram with PDB data
ERRFI1/EGFRcrystal structure of EGFR kinase domain in complex with Mitogen-inducible gene 6 protein
ERRFI1/EGFRCrystal structure of the complex between the EGFR kinase domain and a Mig6 peptide