Search Keyword:


Search option:


IID00289
 UniprotO15164
ProteinTranscription intermediary factor 1-alpha
GeneTRIM24
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1050
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 824-1006 Hetero dimer :
 Evidence X-RAY 3o36 B Reference
       Region 3o36 B 824-883 order
       Region 3o36 B 884-890 disorder
       Region 3o36 B 891-1006 order
Seq 824-1006 Monomer :
 Evidence X-RAY 4zql B Reference
       Region 4zql B 825-884 order
       Region 4zql B 885-891 disorder
       Region 4zql B 892-1006 order
 Evidence X-RAY 4zql A Reference
       Region 4zql A 825-884 order
       Region 4zql A 885-890 disorder
       Region 4zql A 891-1006 order
 Evidence X-RAY 4yc9 A Reference
       Region 4yc9 A 824-886 order
       Region 4yc9 A 887-890 disorder
       Region 4yc9 A 891-1006 order
 Evidence X-RAY 4ybt A Reference
       Region 4ybt A 824-885 order
       Region 4ybt A 886-890 disorder
       Region 4ybt A 891-1006 order
 Evidence X-RAY 4ybs A Reference
       Region 4ybs A 824-885 order
       Region 4ybs A 886-890 disorder
       Region 4ybs A 891-1006 order
 Evidence X-RAY 4ybm B Reference
       Region 4ybm B 824-824 disorder
       Region 4ybm B 825-885 order
       Region 4ybm B 886-897 disorder
       Region 4ybm B 898-1006 order
 Evidence X-RAY 4ybm A Reference
       Region 4ybm A 824-885 order
       Region 4ybm A 886-891 disorder
       Region 4ybm A 892-1006 order
 Evidence X-RAY 4yax B Reference
       Region 4yax B 824-885 order
       Region 4yax B 886-890 disorder
       Region 4yax B 891-1006 order
 Evidence X-RAY 4yax A Reference
       Region 4yax A 824-886 order
       Region 4yax A 887-890 disorder
       Region 4yax A 891-1006 order
 Evidence X-RAY 4yat B Reference
       Region 4yat B 824-824 disorder
       Region 4yat B 825-883 order
       Region 4yat B 884-891 disorder
       Region 4yat B 892-954 order
       Region 4yat B 955-956 disorder
       Region 4yat B 957-1006 order
 Evidence X-RAY 4yat A Reference
       Region 4yat A 824-881 order
       Region 4yat A 882-890 disorder
       Region 4yat A 891-955 order
       Region 4yat A 956-956 disorder
       Region 4yat A 957-1006 order
 Evidence X-RAY 4yad B Reference
       Region 4yad B 824-885 order
       Region 4yad B 886-890 disorder
       Region 4yad B 891-1006 order
 Evidence X-RAY 4yad A Reference
       Region 4yad A 824-885 order
       Region 4yad A 886-890 disorder
       Region 4yad A 891-1006 order
 Evidence X-RAY 4yab B Reference
       Region 4yab B 824-881 order
       Region 4yab B 882-890 disorder
       Region 4yab B 891-1006 order
 Evidence X-RAY 4yab A Reference
       Region 4yab A 824-884 order
       Region 4yab A 885-890 disorder
       Region 4yab A 891-1006 order
 Evidence X-RAY 3o33 D Reference
       Region 3o33 D 824-824 disorder
       Region 3o33 D 825-881 order
       Region 3o33 D 882-891 disorder
       Region 3o33 D 892-1006 order
 Evidence X-RAY 3o33 C Reference
       Region 3o33 C 824-885 order
       Region 3o33 C 886-890 disorder
       Region 3o33 C 891-1006 order
 Evidence X-RAY 3o33 B Reference
       Region 3o33 B 824-1006 order
 Evidence X-RAY 3o33 A Reference
       Region 3o33 A 824-824 disorder
       Region 3o33 A 825-881 order
       Region 3o33 A 882-891 disorder
       Region 3o33 A 892-1006 order
 Evidence X-RAY 5h1v B Reference
       Region 5h1v B 824-824 disorder
       Region 5h1v B 825-881 order
       Region 5h1v B 882-891 disorder
       Region 5h1v B 892-954 order
       Region 5h1v B 955-956 disorder
       Region 5h1v B 957-1006 order
 Evidence X-RAY 5h1v A Reference
       Region 5h1v A 824-824 disorder
       Region 5h1v A 825-880 order
       Region 5h1v A 881-891 disorder
       Region 5h1v A 892-954 order
       Region 5h1v A 955-956 disorder
       Region 5h1v A 957-1006 order
 Evidence X-RAY 5h1u D Reference
       Region 5h1u D 824-825 disorder
       Region 5h1u D 826-886 order
       Region 5h1u D 887-891 disorder
       Region 5h1u D 892-1006 order
 Evidence X-RAY 5h1u C Reference
       Region 5h1u C 824-885 order
       Region 5h1u C 886-891 disorder
       Region 5h1u C 892-1006 order
 Evidence X-RAY 5h1u A Reference
       Region 5h1u A 824-826 disorder
       Region 5h1u A 827-884 order
       Region 5h1u A 885-890 disorder
       Region 5h1u A 891-1006 order
 Evidence X-RAY 5h1u B Reference
       Region 5h1u B 824-826 disorder
       Region 5h1u B 827-885 order
       Region 5h1u B 886-891 disorder
       Region 5h1u B 892-1006 order
 Evidence X-RAY 5h1t D Reference
       Region 5h1t D 824-824 disorder
       Region 5h1t D 825-881 order
       Region 5h1t D 882-891 disorder
       Region 5h1t D 892-1006 order
 Evidence X-RAY 5h1t C Reference
       Region 5h1t C 824-885 order
       Region 5h1t C 886-890 disorder
       Region 5h1t C 891-1006 order
 Evidence X-RAY 5h1t B Reference
       Region 5h1t B 824-825 disorder
       Region 5h1t B 826-886 order
       Region 5h1t B 887-889 disorder
       Region 5h1t B 890-1006 order
 Evidence X-RAY 5h1t A Reference
       Region 5h1t A 824-824 disorder
       Region 5h1t A 825-881 order
       Region 5h1t A 882-891 disorder
       Region 5h1t A 892-1006 order
Seq 824-1006 Hetero dimer :
 Evidence X-RAY 3o35 B Reference
       Region 3o35 B 824-885 order
       Region 3o35 B 886-890 disorder
       Region 3o35 B 891-1006 order
Seq 824-1006 Hetero dimer : IID00058Complex
 Evidence X-RAY 3o36 A Reference
       Region 3o36 A 824-1006 order
Seq 824-1006 Hetero dimer : IID00062Complex
 Evidence X-RAY 3o35 A Reference
       Region 3o35 A 824-884 order
       Region 3o35 A 885-889 disorder
       Region 3o35 A 890-1006 order
 Evidence X-RAY 3o34 A Reference
       Region 3o34 A 824-825 disorder
       Region 3o34 A 826-887 order
       Region 3o34 A 888-891 disorder
       Region 3o34 A 892-1006 order
Seq 824-1006 Hetero dimer : IID00062Complex
 Evidence X-RAY 3o37 D Reference
       Region 3o37 D 824-824 disorder
       Region 3o37 D 825-882 order
       Region 3o37 D 883-890 disorder
       Region 3o37 D 891-1006 order
 Evidence X-RAY 3o37 C Reference
       Region 3o37 C 824-882 order
       Region 3o37 C 883-889 disorder
       Region 3o37 C 890-1006 order
 Evidence X-RAY 3o37 B Reference
       Region 3o37 B 824-824 disorder
       Region 3o37 B 825-885 order
       Region 3o37 B 886-887 disorder
       Region 3o37 B 888-1006 order
 Evidence X-RAY 3o37 A Reference
       Region 3o37 A 824-824 disorder
       Region 3o37 A 825-882 order
       Region 3o37 A 883-889 disorder
       Region 3o37 A 890-1006 order
Seq 891-1012 Homo dimer :
 Evidence X-RAY 2yyn D Reference
       Region 2yyn D 891-898 disorder
       Region 2yyn D 899-1011 order
       Region 2yyn D 1012-1012 disorder
 Evidence X-RAY 2yyn C Reference
       Region 2yyn C 891-898 disorder
       Region 2yyn C 899-1011 order
       Region 2yyn C 1012-1012 disorder
 Evidence X-RAY 2yyn B Reference
       Region 2yyn B 891-898 disorder
       Region 2yyn B 899-1012 order
 Evidence X-RAY 2yyn A Reference
       Region 2yyn A 891-898 disorder
       Region 2yyn A 899-1011 order
       Region 2yyn A 1012-1012 disorder
Seqphosphorylation
    1042-1042 Phosphoserine
    1028-1028 Phosphoserine
    1025-1025 Phosphoserine
    1019-1019 Phosphoserine
    818-818 Phosphothreonine
    811-811 Phosphoserine
    808-808 Phosphoserine
    744-744 Phosphoserine
    768-768 Phosphoserine; by ATM
    667-667 Phosphoserine
    660-660 Phosphoserine
    654-654 Phosphoserine
    110-110 Phosphoserine
    101-101 Phosphothreonine
 
Prediction
NeProc
Disorder 1-49,92-119,209-216,428-821,877-897,1014-1050
Order 50-87,120-150,158-208,217-427,822-876,898-1013
ProS 115-119,567-573,609-626,675-681,694-703,708-721,733-739,748-754,877-883,1023-1050
AlphaFold
Disorder 1-52,90-120,147-160,207-219,419-419,426-466,468-469,476-477,479-560,562-822,884-898,955-957,1013-1050
Order 53-89,121-146,161-206,220-418,420-425,467-467,470-475,478-478,561-561,823-883,899-954,958-1012
Pfam Hmmer
PF00643 158-205 8.4e-14
PF00643 218-259 3.3e-15
PF00628 828-873 9.1e-16
PF00439 901-992 2.3e-33
SEG 2-30 ,102-117 ,473-491 ,499-514 ,577-595 ,685-708 ,758-773 ,1017-1032
Function
Function in SwissProt
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).