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IID00290
 UniprotP01135
ProteinProtransforming growth factor alpha
GeneTGFA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
160
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 40-89 Monomer :
 Evidence NMR 1yug A Reference
       Region 1yug A 40-89 order
       Region 1yug A 40-42 high_rmsd
       Region 1yug A 50-53 high_rmsd
       Region 1yug A 87-89 high_rmsd
 Evidence NMR 1yuf A Reference
       Region 1yuf A 40-89 order
       Region 1yuf A 40-42 high_rmsd
       Region 1yuf A 50-53 high_rmsd
       Region 1yuf A 87-89 high_rmsd
 Evidence NMR 4tgf A Reference
       Region 4tgf A 40-89 order
       Region 4tgf A 40-42 high_rmsd
       Region 4tgf A 88-89 high_rmsd
 Evidence NMR 3tgf A Reference
       Region 3tgf A 40-89 order
       Region 3tgf A 40-42 high_rmsd
       Region 3tgf A 49-52 high_rmsd
       Region 3tgf A 88-89 high_rmsd
 Evidence NMR 2tgf A Reference
       Region 2tgf A 40-89 order
Seq 40-89 Hetero tetramer : IID00262Complex
 Evidence X-RAY 1mox D Reference
       Region 1mox D 40-41 disorder
       Region 1mox D 42-89 order
 Evidence X-RAY 1mox C Reference
       Region 1mox C 40-40 disorder
       Region 1mox C 41-89 order
Seq 49-88 Hetero trimer :
 Evidence X-RAY 5kn5 F Reference
       Region 5kn5 F 49-49 disorder
       Region 5kn5 F 50-88 order
Seq 49-88 Hetero trimer :
 Evidence X-RAY 5kn5 C Reference
       Region 5kn5 C 49-88 order
Seq 83-89 Monomer : P01132
 Evidence NMR 1gk5 A Reference
       Region 1gk5 A 83-89 order
       Region 1gk5 A 89-89 high_rmsd
 
Prediction
NeProc
Disorder 1-34,94-98,122-160
Order 35-93,99-121
ProS 1-31,94-98,122-140,145-160
AlphaFold
Disorder 1-5,23-23,26-45,48-52,88-95,126-160
Order 6-22,24-25,46-47,53-87,96-125
Pfam Hmmer
PF00008 47-82 0.00015
SEG 28-42 ,99-117
Function
Function in SwissProt
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.