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IID00295
 UniprotP06748
ProteinNucleophosmin
GeneNPM1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
294
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 9-122 Homo decamer :
 Evidence X-RAY 2p1b J Reference
       Region 2p1b J 9-14 disorder
       Region 2p1b J 15-34 order
       Region 2p1b J 35-38 disorder
       Region 2p1b J 39-118 order
       Region 2p1b J 119-122 disorder
 Evidence X-RAY 2p1b I Reference
       Region 2p1b I 9-14 disorder
       Region 2p1b I 15-34 order
       Region 2p1b I 35-38 disorder
       Region 2p1b I 39-118 order
       Region 2p1b I 119-122 disorder
 Evidence X-RAY 2p1b H Reference
       Region 2p1b H 9-14 disorder
       Region 2p1b H 15-34 order
       Region 2p1b H 35-38 disorder
       Region 2p1b H 39-118 order
       Region 2p1b H 119-122 disorder
 Evidence X-RAY 2p1b G Reference
       Region 2p1b G 9-14 disorder
       Region 2p1b G 15-34 order
       Region 2p1b G 35-38 disorder
       Region 2p1b G 39-118 order
       Region 2p1b G 119-122 disorder
 Evidence X-RAY 2p1b F Reference
       Region 2p1b F 9-14 disorder
       Region 2p1b F 15-34 order
       Region 2p1b F 35-38 disorder
       Region 2p1b F 39-118 order
       Region 2p1b F 119-122 disorder
 Evidence X-RAY 2p1b E Reference
       Region 2p1b E 9-14 disorder
       Region 2p1b E 15-34 order
       Region 2p1b E 35-38 disorder
       Region 2p1b E 39-118 order
       Region 2p1b E 119-122 disorder
 Evidence X-RAY 2p1b D Reference
       Region 2p1b D 9-14 disorder
       Region 2p1b D 15-34 order
       Region 2p1b D 35-38 disorder
       Region 2p1b D 39-118 order
       Region 2p1b D 119-122 disorder
 Evidence X-RAY 2p1b C Reference
       Region 2p1b C 9-14 disorder
       Region 2p1b C 15-34 order
       Region 2p1b C 35-38 disorder
       Region 2p1b C 39-118 order
       Region 2p1b C 119-122 disorder
 Evidence X-RAY 2p1b B Reference
       Region 2p1b B 9-14 disorder
       Region 2p1b B 15-34 order
       Region 2p1b B 35-38 disorder
       Region 2p1b B 39-118 order
       Region 2p1b B 119-122 disorder
 Evidence X-RAY 2p1b A Reference
       Region 2p1b A 9-14 disorder
       Region 2p1b A 15-34 order
       Region 2p1b A 35-38 disorder
       Region 2p1b A 39-118 order
       Region 2p1b A 119-122 disorder
Seq 9-124 Homo eicosamer :
 Evidence X-RAY 5ehd j Reference
       Region 5ehd j 9-12 disorder
       Region 5ehd j 13-118 order
       Region 5ehd j 119-124 disorder
 Evidence X-RAY 5ehd h Reference
       Region 5ehd h 13-118 order
       Region 5ehd h 119-124 disorder
 Evidence X-RAY 5ehd f Reference
       Region 5ehd f 9-13 disorder
       Region 5ehd f 14-119 order
 Evidence X-RAY 5ehd e Reference
       Region 5ehd e 9-12 disorder
       Region 5ehd e 13-119 order
 Evidence X-RAY 5ehd d Reference
       Region 5ehd d 9-12 disorder
       Region 5ehd d 13-119 order
       Region 5ehd d 120-124 disorder
 Evidence X-RAY 5ehd c Reference
       Region 5ehd c 9-13 disorder
       Region 5ehd c 14-119 order
 Evidence X-RAY 5ehd J Reference
       Region 5ehd J 9-13 disorder
       Region 5ehd J 14-120 order
       Region 5ehd J 121-124 disorder
 Evidence X-RAY 5ehd I Reference
       Region 5ehd I 9-12 disorder
       Region 5ehd I 13-119 order
       Region 5ehd I 120-124 disorder
 Evidence X-RAY 5ehd H Reference
       Region 5ehd H 9-12 disorder
       Region 5ehd H 13-119 order
       Region 5ehd H 120-124 disorder
 Evidence X-RAY 5ehd G Reference
       Region 5ehd G 9-13 disorder
       Region 5ehd G 14-119 order
       Region 5ehd G 120-124 disorder
 Evidence X-RAY 5ehd F Reference
       Region 5ehd F 9-12 disorder
       Region 5ehd F 13-119 order
       Region 5ehd F 120-124 disorder
 Evidence X-RAY 5ehd E Reference
       Region 5ehd E 9-13 disorder
       Region 5ehd E 14-119 order
       Region 5ehd E 120-124 disorder
 Evidence X-RAY 5ehd D Reference
       Region 5ehd D 9-13 disorder
       Region 5ehd D 14-118 order
       Region 5ehd D 119-124 disorder
 Evidence X-RAY 5ehd C Reference
       Region 5ehd C 9-12 disorder
       Region 5ehd C 13-119 order
       Region 5ehd C 120-124 disorder
 Evidence X-RAY 5ehd B Reference
       Region 5ehd B 9-13 disorder
       Region 5ehd B 14-118 order
       Region 5ehd B 119-124 disorder
 Evidence X-RAY 5ehd A Reference
       Region 5ehd A 9-13 disorder
       Region 5ehd A 14-119 order
       Region 5ehd A 120-124 disorder
Seqdisorder 120-243
 Evidence CD Reference
       Region 120-243 disorder
       Region 189-243 disorder
Seq 225-294 Monomer :
 Evidence NMR 2vxd A Reference
       Region 2vxd A 243-294 order
 Evidence NMR 2llh A Reference
       Region 2llh A 225-294 order
       Region 2llh A 225-238 high_rmsd
Seqphosphorylation
    254-254 Phosphoserine
    279-279 Phosphothreonine
    254-254 Phosphoserine
    260-260 Phosphoserine
    242-242 Phosphoserine
    243-243 Phosphoserine
    237-237 Phosphothreonine; by CDK1
    234-234 Phosphothreonine; by CDK1
    227-227 Phosphoserine
    219-219 Phosphothreonine; by CDK1
    199-199 Phosphothreonine; by CDK1
    137-137 Phosphoserine
    139-139 Phosphoserine
    125-125 Phosphoserine; by CDK2
    95-95 Phosphothreonine
    75-75 Phosphothreonine
    70-70 Phosphoserine
    43-43 Phosphoserine
    67-67 Phosphotyrosine
    10-10 Phosphoserine
    4-4 Phosphoserine; by PLK1 and PLK2
Seqacetylation
    257-257 N6-acetyllysine
    273-273 N6-acetyllysine; alternate
    292-292 N6-acetyllysine
    257-257 N6-acetyllysine; alternate
    267-267 N6-acetyllysine; alternate
    250-250 N6-acetyllysine; alternate
    230-230 N6-acetyllysine; alternate
    229-229 N6-acetyllysine
    212-212 N6-acetyllysine
    150-150 N6-acetyllysine; alternate
    154-154 N6-acetyllysine
    32-32 N6-acetyllysine; alternate
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-13,120-263
Order 14-119,264-294
ProS 196-212,245-263
AlphaFold
Disorder 1-12,120-242
Order 13-119,243-294
Pfam Hmmer
PF03066 13-211 1.1e-78
SEG 117-133 ,159-188
Function
Function in SwissProt
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029).