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IID00299
 UniprotP19878
ProteinNeutrophil cytosol factor 2
GeneNCF2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
526
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-203 Hetero dimer : IID00312Complex
 Evidence X-RAY 1e96 B Reference
       Region 1e96 B 1-1 disorder
       Region 1e96 B 2-186 order
       Region 1e96 B 187-203 disorder
Seq 1-213 Monomer :
 Evidence X-RAY 1wm5 A Reference
       Region 1wm5 A 1-193 order
       Region 1wm5 A 194-195 disorder
       Region 1wm5 A 196-203 order
 Evidence X-RAY 1hh8 A Reference
       Region 1hh8 A 1-1 disorder
       Region 1hh8 A 2-193 order
       Region 1hh8 A 194-213 disorder
Seq 243-297 Monomer :
 Evidence NMR 2dmo A Reference
       Region 2dmo A 243-297 order
Seq 352-429 Hetero dimer : IID00593Complex
 Evidence X-RAY 1oey D Reference
       Region 1oey D 352-428 order
       Region 1oey D 429-429 disorder
 Evidence X-RAY 1oey C Reference
       Region 1oey C 352-428 order
       Region 1oey C 429-429 disorder
 Evidence X-RAY 1oey B Reference
       Region 1oey B 352-427 order
       Region 1oey B 428-429 disorder
 Evidence X-RAY 1oey A Reference
       Region 1oey A 352-428 order
       Region 1oey A 429-429 disorder
Seq 455-516 Hetero dimer : IID00597Complex
 Evidence NMR 1k4u S Reference
       Region 1k4u S 455-516 order
       Region 1k4u S 455-456 high_rmsd
       Region 1k4u S 516-516 high_rmsd
Seqphosphorylation
    399-399 Phosphoserine
    233-233 Phosphothreonine
 
Prediction
NeProc
Disorder 206-351,392-395,419-455,516-526
Order 1-205,352-391,396-418,456-515
ProS 206-255,281-290,310-314,337-351,392-395,419-428
AlphaFold
Disorder 195-196,199-199,202-242,298-350,429-457,515-526
Order 1-194,197-198,200-201,243-297,351-428,458-514
Pfam Hmmer
PF00515 71-104 2.3e-06
PF00018 243-297 3.6e-16
PF00564 351-429 1e-12
PF00018 460-514 2.9e-22
SEG 132-147 ,218-234 ,303-315
Function
Function in SwissProt
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).