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IID00302
 UniprotP37840
ProteinAlpha-synuclein
GeneSNCA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
140
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-12 Monomer :
 Evidence NMR 2jn5 A Reference
       Region 2jn5 A 1-12 order
Seq 1-19 Hetero dimer : IID00706Complex
 Evidence NMR 2m55 B Reference
       Region 2m55 B 1-19 order
       Region 2m55 B 17-19 high_rmsd
Seq 1-19 Monomer : IID90020Complex
 Evidence X-RAY 3q25 A Reference
       Region 3q25 A 1-19 order
Seq 1-19 Homo dimer : IID90020Complex
 Evidence X-RAY 3q29 C Reference
       Region 3q29 C 1-14 order
       Region 3q29 C 15-19 disorder
 Evidence X-RAY 3q29 A Reference
       Region 3q29 A 1-11 order
       Region 3q29 A 12-19 disorder
Seqdisorder 1-140
 Evidence CD Reference
       Region 1-140 disorder
Seq 1-140 Homo decamer :
 Evidence NMR 2n0a J Reference
       Region 2n0a J 1-140 order
 Evidence NMR 2n0a I Reference
       Region 2n0a I 1-140 order
 Evidence NMR 2n0a H Reference
       Region 2n0a H 1-140 order
 Evidence NMR 2n0a G Reference
       Region 2n0a G 1-140 order
 Evidence NMR 2n0a F Reference
       Region 2n0a F 1-140 order
 Evidence NMR 2n0a E Reference
       Region 2n0a E 1-140 order
 Evidence NMR 2n0a D Reference
       Region 2n0a D 1-140 order
 Evidence NMR 2n0a C Reference
       Region 2n0a C 1-140 order
 Evidence NMR 2n0a B Reference
       Region 2n0a B 1-140 order
 Evidence NMR 2n0a A Reference
       Region 2n0a A 1-140 order
Seq 1-140 Monomer :
 Evidence NMR 1xq8 A Reference
       Region 1xq8 A 1-97 order
       Region 1xq8 A 98-140 disorder
 Evidence NMR 2kkw A Reference
       Region 2kkw A 1-93 order
       Region 2kkw A 94-140 disorder
Seq 10-42 Monomer : IID90020Complex
 Evidence X-RAY 3q26 A Reference
       Region 3q26 A 10-11 order
       Region 3q26 A 12-19 disorder
       Region 3q26 A 20-42 order
Seq 31-41 Hetero dimer : IID50214Complex
 Evidence X-RAY 5crw B Reference
       Region 5crw B 31-41 order
Seq 32-57 Monomer : IID90020Complex
 Evidence X-RAY 3q27 A Reference
       Region 3q27 A 32-36 disorder
       Region 3q27 A 37-56 order
       Region 3q27 A 57-57 disorder
Seq 35-56 Hetero trimer :
 Evidence NMR 4bxl C Reference
       Region 4bxl C 35-56 order
Seq 58-79 Monomer : IID90020Complex
 Evidence X-RAY 3q28 A Reference
       Region 3q28 A 58-72 order
       Region 3q28 A 73-79 disorder
Seq 69-78 Homo decamer :
 Evidence X-RAY 4rik A Reference
       Region 4rik A 69-77 order
 Evidence X-RAY 4r0w A Reference
       Region 4r0w A 70-76 order
 Evidence X-RAY 4r0u A Reference
       Region 4r0u A 72-78 order
Seq 132-140 Hetero dimer :
 Evidence X-RAY 2x6m B Reference
       Region 2x6m B 132-134 disorder
       Region 2x6m B 135-140 order
SeqProS verified 1-12 This region is ordered in the complex with Synphilin-1 :
       Region 2jn5 A 1-12 order
       Region 1-140 disorder
SeqProS verified 1-19 : IID90020Complex
       Region 3q25 A 1-19 order
       Region 1-140 disorder
SeqProS verified 1-19 Homo dimer : IID90020Complex
       Region 3q29 A 1-11 order
       Region 3q29 C 1-14 order
       Region 1-140 disorder
SeqProS verified 1-19 Hetero dimer : IID00706Complex
       Region 2m55 B 1-19 order
       Region 1-140 disorder
SeqProS verified 1-97 This region is ordered in the micelle bound. (in vitro) :
       Region 1xq8 A 1-97 order
       Region 2kkw A 1-93 order
       Region 1-140 disorder
SeqProS verified 10-11,20-42 : IID90020Complex
       Region 3q26 A 10-11 order
       Region 3q26 A 20-42 order
       Region 1-140 disorder
SeqProS verified 31-41 Hetero dimer : IID50214Complex
       Region 5crw B 31-41 order
       Region 1-140 disorder
SeqProS verified 35-56 This region is ordered in the complex with beta wrapin AS69(engineered protein). Hetero trimer :
       Region 4bxl C 35-56 order
       Region 1-140 disorder
SeqProS verified 37-56 : IID90020Complex
       Region 3q27 A 37-56 order
       Region 1-140 disorder
SeqProS verified 58-72 : IID90020Complex
       Region 3q28 A 58-72 order
       Region 1-140 disorder
SeqProS verified 135-140 This region is ordered in the complex with NbSyn2. (in vitro) Hetero dimer :
       Region 2x6m B 135-140 order
       Region 1-140 disorder
Seqphosphorylation
    125-125 Phosphotyrosine; by FYN
    87-87 Phosphoserine
    129-129 Phosphoserine; by BARK1
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-140
ProS 1-27,32-38,45-97,122-127,132-140
AlphaFold
Disorder 89-140
Order 1-88
Pfam Hmmer
PF01387 1-132 1e-73
SEG 10-23 ,63-78
Function
Function in SwissProt
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590).