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IID00304
 UniprotP46937
ProteinTranscriptional coactivator YAP1
GeneYAP1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
504
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 50-100 Hetero tetramer : Q15561
 Evidence X-RAY 6gek M Reference
       Region 6gek M 60-61 disorder
       Region 6gek M 62-74 order
       Region 6gek M 75-82 disorder
       Region 6gek M 83-99 order
       Region 6gek M 100-100 disorder
 Evidence X-RAY 6gek L Reference
       Region 6gek L 60-75 order
       Region 6gek L 76-81 disorder
       Region 6gek L 82-99 order
       Region 6gek L 100-100 disorder
 Evidence X-RAY 8a8r M Reference
       Region 8a8r M 50-52 disorder
       Region 8a8r M 53-72 order
       Region 8a8r M 73-82 disorder
       Region 8a8r M 83-99 order
       Region 8a8r M 100-100 disorder
 Evidence X-RAY 8a8r L Reference
       Region 8a8r L 50-52 disorder
       Region 8a8r L 53-75 order
       Region 8a8r L 76-83 disorder
       Region 8a8r L 84-99 order
       Region 8a8r L 100-100 disorder
Seq 50-171 Hetero dimer : IID00547Complex
 Evidence X-RAY 3kys B Reference
       Region 3kys B 50-50 disorder
       Region 3kys B 51-100 order
       Region 3kys B 101-171 disorder
 Evidence X-RAY 3kys D Reference
       Region 3kys D 50-51 disorder
       Region 3kys D 52-100 order
       Region 3kys D 101-171 disorder
 Evidence X-RAY 4re1 D Reference
       Region 4re1 D 50-52 disorder
       Region 4re1 D 53-99 order
       Region 4re1 D 100-171 disorder
 Evidence X-RAY 4re1 C Reference
       Region 4re1 C 50-99 order
       Region 4re1 C 100-171 disorder
Seqdisorder 50-171
 Evidence NMR The very narrow peak dispersion in the 1H dimension of the 1H-15N HSQC spectrum shows that YAP 50-171 is intrinsically disordered. Nevertheless, the secondary structure propensity (SSP) score clearly indicates a propensity for a preformation of the alpha-helix and the N-terminal beta-strand in the unbound state (PMID: 29372459). Reference
       Region 50-171 disorder
Seq 51-99 Hetero tetramer : P30052
 Evidence X-RAY 8a8q D Reference
       Region 8a8q D 51-76 order
       Region 8a8q D 77-81 disorder
       Region 8a8q D 82-99 order
 Evidence X-RAY 8a8q C Reference
       Region 8a8q C 51-75 order
       Region 8a8q C 76-81 disorder
       Region 8a8q C 82-99 order
Seq 60-100 Hetero dimer : Q15561
 Evidence X-RAY 5oaq L Reference
       Region 5oaq L 60-99 order
       Region 5oaq L 100-100 disorder
 Evidence X-RAY 6ge3 L Reference
       Region 6ge3 L 60-99 order
       Region 6ge3 L 100-100 disorder
 Evidence X-RAY 6ge4 L Reference
       Region 6ge4 L 60-99 order
       Region 6ge4 L 100-100 disorder
 Evidence X-RAY 6ge5 L Reference
       Region 6ge5 L 60-99 order
       Region 6ge5 L 100-100 disorder
 Evidence X-RAY 6ge6 L Reference
       Region 6ge6 L 60-99 order
       Region 6ge6 L 100-100 disorder
 Evidence X-RAY 6gec L Reference
       Region 6gec L 60-99 order
 Evidence X-RAY 6gee L Reference
       Region 6gee L 60-99 order
 Evidence X-RAY 6geg L Reference
       Region 6geg L 60-99 order
 Evidence X-RAY 6gei L Reference
       Region 6gei L 60-99 order
       Region 6gei L 100-100 disorder
 Evidence X-RAY 6hik L Reference
       Region 6hik L 60-99 order
 Evidence X-RAY 6q2x L Reference
       Region 6q2x L 60-99 order
       Region 6q2x L 100-100 disorder
Seq 60-100 Hetero octamer : IID00547Complex
 Evidence X-RAY 6hil O Reference
       Region 6hil O 60-63 disorder
       Region 6hil O 64-98 order
       Region 6hil O 99-100 disorder
 Evidence X-RAY 6hil N Reference
       Region 6hil N 60-63 disorder
       Region 6hil N 64-98 order
       Region 6hil N 99-100 disorder
 Evidence X-RAY 6hil M Reference
       Region 6hil M 60-63 disorder
       Region 6hil M 64-98 order
       Region 6hil M 99-100 disorder
 Evidence X-RAY 6hil L Reference
       Region 6hil L 60-63 disorder
       Region 6hil L 64-98 order
       Region 6hil L 99-100 disorder
Seq 124-133 Hetero dimer : IID00301Complex
 Evidence X-RAY 3mhr P Reference
       Region 3mhr P 124-133 order
 Evidence X-RAY 6g6x P Reference
       Region 6g6x P 124-124 disorder
       Region 6g6x P 125-128 order
       Region 6g6x P 129-129 disorder
       Region 6g6x P 130-133 order
 Evidence X-RAY 6g8i P Reference
       Region 6g8i P 125-133 order
 Evidence X-RAY 6g8j P Reference
       Region 6g8j P 124-124 disorder
       Region 6g8j P 125-130 order
       Region 6g8j P 131-133 disorder
 Evidence X-RAY 6g8k P Reference
       Region 6g8k P 124-124 disorder
       Region 6g8k P 125-129 order
       Region 6g8k P 130-133 disorder
 Evidence X-RAY 6g8l P Reference
       Region 6g8l P 124-124 disorder
       Region 6g8l P 125-131 order
       Region 6g8l P 132-132 disorder
       Region 6g8l P 133-133 order
 Evidence X-RAY 6g8p P Reference
       Region 6g8p P 124-124 disorder
       Region 6g8p P 125-128 order
       Region 6g8p P 129-133 disorder
 Evidence X-RAY 6g8q P Reference
       Region 6g8q P 124-124 disorder
       Region 6g8q P 125-131 order
       Region 6g8q P 132-132 disorder
 Evidence X-RAY 7o07 P Reference
       Region 7o07 P 124-130 order
       Region 7o07 P 131-131 disorder
       Region 7o07 P 132-133 order
Seq 164-209 Monomer :
 Evidence X-RAY 4rex A Reference
       Region 4rex A 165-208 order
       Region 4rex A 209-209 disorder
 Evidence NMR 5ydx A This entry is chimeric, consisting of YAP (P46937, S164-M206) and LATS1 (O95835, N551-H562); manually corrected. Reference
       Region 5ydx A 164-206 order
       Region 5ydx A 164-168 high_rmsd
Seq 165-204 Hetero dimer :
 Evidence NMR 1k9r A Reference
       Region 1k9r A 165-204 order
       Region 1k9r A 165-170 high_rmsd
       Region 1k9r A 204-204 high_rmsd
Seq 165-204 Hetero dimer :
 Evidence NMR 1k9q A Reference
       Region 1k9q A 165-204 order
       Region 1k9q A 165-170 high_rmsd
Seq 165-210 Hetero dimer : Q96G27
 Evidence NMR 1k5r A Reference
       Region 1k5r A 165-204 order
       Region 1k5r A 165-171 high_rmsd
       Region 1k5r A 203-204 high_rmsd
 Evidence NMR 1jmq A Reference
       Region 1jmq A 165-210 order
       Region 1jmq A 165-165 high_rmsd
       Region 1jmq A 208-210 high_rmsd
Seq 170-205 Hetero dimer : IID00135Complex
 Evidence NMR 2ltw A Reference
       Region 2ltw A 170-205 order
Seq 170-205 Hetero dimer : IID00174Complex
 Evidence NMR 2lax A Reference
       Region 2lax A 170-205 order
 Evidence NMR 2lay A Reference
       Region 2lay A 170-205 order
Seq 229-266 Monomer :
 Evidence NMR 5ydy A This entry is chimeric, consisting of YAP (P46937, S229-R266) and LATS1 (O95835, N369-A380); manually corrected. Reference
       Region 5ydy A 229-266 order
       Region 5ydy A 229-229 high_rmsd
       Region 5ydy A 265-266 high_rmsd
Seq 230-263 Hetero dimer : IID00174Complex
 Evidence NMR 2law A Reference
       Region 2law A 230-263 order
Seq 230-265 Hetero dimer : IID00135Complex
 Evidence NMR 2ltv A Reference
       Region 2ltv A 230-265 order
SeqProS verified 51-100 Only representative PDB entries are shown as ProS evidence. Hetero dimer : IID00547Complex
       Region 3kys D 52-100 order
       Region 3kys B 51-100 order
       Region 50-171 disorder
SeqProS verified 51-100 Only representative PDB entries are shown as ProS evidence. Hetero octamer : IID00547Complex
       Region 6hil L 64-98 order
       Region 6hil M 64-98 order
       Region 6hil N 64-98 order
       Region 6hil O 64-98 order
       Region 50-171 disorder
SeqProS verified 53-99 Only representative PDB entries are shown as ProS evidence. Hetero tetramer : Q15561
       Region 8a8r L 53-75 order
       Region 8a8r L 84-99 order
       Region 8a8r M 53-72 order
       Region 8a8r M 83-99 order
       Region 50-171 disorder
SeqProS verified 53-99 Only representative PDB entries are shown as ProS evidence. Hetero dimer : Q15561
       Region 5oaq L 60-99 order
       Region 6ge3 L 60-99 order
       Region 6hik L 60-99 order
       Region 6q2x L 60-99 order
       Region 50-171 disorder
SeqProS verified 124-133 Hetero dimer : IID00301Complex
       Region 3mhr P 124-133 order
       Region 7o07 P 124-130 order
       Region 3kys B 101-171 disorder
Seqphosphorylation
    382-382 Phosphoserine
    388-388 Phosphoserine
    371-371 Phosphoserine
    397-397 Phosphoserine; by LATS1 and LATS2
    381-381 Phosphoserine
    289-289 Phosphoserine
    367-367 Phosphoserine; by MAPK8 and MAPK9
    164-164 Phosphoserine; by LATS1 and LATS2
    274-274 Phosphoserine
    154-154 Phosphothreonine; by MAPK8 and MAPK9
    138-138 Phosphoserine; by MAPK8 and MAPK9
    128-128 Phosphoserine
    131-131 Phosphoserine
    127-127 Phosphoserine; by LATS1 and LATS2
    110-110 Phosphothreonine
    119-119 Phosphothreonine; by MAPK8 and MAPK9
    105-105 Phosphoserine
    109-109 Phosphoserine; by LATS1 and LATS2
    63-63 Phosphothreonine
    61-61 Phosphoserine; by LATS1 and LATS2
    400-400 Phosphoserine; by CK1
    407-407 Phosphotyrosine; by ABL1
    412-412 Phosphothreonine; by MAPK8 and MAPK9
    403-403 Phosphoserine; by CK1
 
Prediction
NeProc
Disorder 1-298,329-386,393-412,459-469,489-499
Order 299-328,387-392,413-458,470-488,500-504
ProS 1-4,55-99,104-118,174-205,231-251,264-271,278-285,329-334,340-355,364-375,382-386,393-412,489-499
AlphaFold
Disorder 1-56,58-58,60-61,75-82,101-170,208-229,265-300,330-504
Order 57-57,59-59,62-74,83-100,171-207,230-264,301-329
Pfam Hmmer
PF00397 173-202 7.2e-13
PF00397 232-261 1e-12
SEG 3-51 ,302-328
Function
Function in SwissProt
Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3).
Biological Process
Diagram with PDB data
YAP1/SFN14-3-3 sigma in complex with YAP pS127-peptide
See also
Diagram with PDB data
LATS1/YAP1NMR structure of YAP1-2 WW1 domain with LATS1 PPxY motif complex
SMAD1/YAP1Structure of the first WW domain of human YAP in complex with a phosphorylated human Smad1 derived peptide
AMOT/SFNCrystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide