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IID00306
 UniprotP53999
ProteinActivated RNA polymerase II transcriptional coactivator p15
GeneSUB1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
127
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 63-127 Hetero trimer : IID90007Complex
 Evidence NMR 2phe A Reference
       Region 2phe A 63-127 order
 Evidence NMR 2phe B Reference
       Region 2phe B 63-127 order
Seq 63-127 Homo dimer :
 Evidence X-RAY 4usg B Reference
       Region 4usg B 63-127 order
 Evidence X-RAY 4usg A Reference
       Region 4usg A 63-127 order
 Evidence X-RAY 1pcf H Reference
       Region 1pcf H 63-127 order
 Evidence X-RAY 1pcf G Reference
       Region 1pcf G 63-127 order
 Evidence X-RAY 1pcf F Reference
       Region 1pcf F 63-127 order
 Evidence X-RAY 1pcf E Reference
       Region 1pcf E 63-127 order
 Evidence X-RAY 1pcf D Reference
       Region 1pcf D 63-127 order
 Evidence X-RAY 1pcf C Reference
       Region 1pcf C 63-127 order
 Evidence X-RAY 1pcf B Reference
       Region 1pcf B 63-127 order
 Evidence X-RAY 1pcf A Reference
       Region 1pcf A 63-127 order
 Evidence X-RAY 2c62 B Reference
       Region 2c62 B 63-127 order
 Evidence X-RAY 2c62 A Reference
       Region 2c62 A 63-127 order
Seqphosphorylation
    55-55 Phosphoserine
    118-118 Phosphoserine
    58-58 Phosphoserine
    57-57 Phosphoserine
    56-56 Phosphoserine
    19-19 Phosphoserine
    17-17 Phosphoserine
    15-15 Phosphoserine
    13-13 Phosphoserine
    11-11 Phosphoserine
    10-10 Phosphoserine
    9-9 Phosphoserine
    4-4 Phosphoserine
Seqacetylation
    68-68 N6-acetyllysine; alternate
    53-53 N6-acetyllysine
    35-35 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-59
Order 60-127
AlphaFold
Disorder 1-3,5-5,7-14,16-60
Order 4-4,6-6,15-15,61-127
Pfam Hmmer
PF02229 34-124 3.1e-53
SEG 3-24 ,46-58
Function
Function in SwissProt
General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).