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IID00307
 UniprotP60604
ProteinUbiquitin-conjugating enzyme E2 G2
GeneUBE2G2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
165
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-165 Monomer :
 Evidence NMR 2kly A Reference
       Region 2kly A 1-165 order
       Region 2kly A 96-106 high_rmsd
 Evidence X-RAY 2cyx C Reference
       Region 2cyx C 1-165 order
 Evidence X-RAY 2cyx B Reference
       Region 2cyx B 1-165 order
 Evidence X-RAY 2cyx A Reference
       Region 2cyx A 1-165 order
Seq 1-165 Hetero dimer : IID00226Complex
 Evidence X-RAY 4lad A Reference
       Region 4lad A 1-2 disorder
       Region 4lad A 3-96 order
       Region 4lad A 97-105 disorder
       Region 4lad A 106-165 order
Seq 2-165 Hetero dimer : IID00226Complex
 Evidence X-RAY 3h8k A Reference
       Region 3h8k A 2-165 order
Seq 2-165 Hetero trimer : IID00226Complex
 Evidence NMR 2lxp A Reference
       Region 2lxp A 2-97 order
       Region 2lxp A 98-105 disorder
       Region 2lxp A 106-165 order
Seqdisorder 95-107
 Evidence NMR Reference
       Region 95-107 disorder
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-5
Order 6-165
AlphaFold
Disorder 1-2
Order 3-165
Pfam Hmmer
PF00179 8-159 7e-83
Function
Function in SwissProt
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:20061386). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386). Involved in endoplasmic reticulum-associated degradation (ERAD) (PubMed:22607976). Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation (PubMed:23223569).