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IID00315
 UniprotQ05066
ProteinSex-determining region Y protein
GeneSRY
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
204
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 56-130 Monomer : P63159
 Evidence NMR 2gzk A Reference
       Region 2gzk A 56-130 order
Seq 56-140 Monomer :
 Evidence NMR 1j47 A Reference
       Region 1j47 A 57-140 order
 Evidence NMR 1j46 A Reference
       Region 1j46 A 57-140 order
 Evidence NMR 1hrz A Reference
       Region 1hrz A 56-57 disorder
       Region 1hrz A 58-130 order
       Region 1hrz A 131-131 disorder
 Evidence NMR 1hry A Reference
       Region 1hry A 56-57 disorder
       Region 1hry A 58-130 order
       Region 1hry A 131-131 disorder
Seqacetylation
    136-136 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-60,133-204
Order 61-132
ProS 5-9,15-18,57-60,158-170,198-204
AlphaFold
Disorder 1-57,140-201,203-204
Order 58-139,202-202
Pfam Hmmer
PF00505 60-128 7.1e-32
Function
Function in SwissProt
Transcriptional regulator that controls a genetic switch in male development (PubMed:11563911). It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (PubMed:16996051, PubMed:16414182). Involved in different aspects of gene regulation including promoter activation or repression (PubMed:9525897). Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (PubMed:1425584, PubMed:8265659, PubMed:8159753, PubMed:11563911, PubMed:15170344). SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending (PubMed:1425584, PubMed:8265659, PubMed:8159753, PubMed:11563911, PubMed:15170344, PubMed:16762365). Also involved in pre-mRNA splicing (PubMed:11818535). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).