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IID00316
 UniprotQ07960
ProteinRho GTPase-activating protein 1
GeneARHGAP1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
439
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 198-439 Hetero dimer : IID00274Complex
 Evidence X-RAY 1tx4 A Reference
       Region 1tx4 A 234-235 disorder
       Region 1tx4 A 236-431 order
 Evidence X-RAY 1ow3 A Reference
       Region 1ow3 A 198-235 disorder
       Region 1ow3 A 236-431 order
       Region 1ow3 A 432-439 disorder
 Evidence X-RAY 5m70 F Reference
       Region 5m70 F 198-239 disorder
       Region 5m70 F 240-253 order
       Region 5m70 F 254-257 disorder
       Region 5m70 F 258-431 order
       Region 5m70 F 432-437 disorder
 Evidence X-RAY 5m70 A Reference
       Region 5m70 A 198-239 disorder
       Region 5m70 A 240-253 order
       Region 5m70 A 254-257 disorder
       Region 5m70 A 258-431 order
       Region 5m70 A 432-437 disorder
 Evidence X-RAY 5m6x H Reference
       Region 5m6x H 198-239 disorder
       Region 5m6x H 240-252 order
       Region 5m6x H 253-257 disorder
       Region 5m6x H 258-431 order
       Region 5m6x H 432-437 disorder
 Evidence X-RAY 5m6x A Reference
       Region 5m6x A 198-239 disorder
       Region 5m6x A 240-253 order
       Region 5m6x A 254-257 disorder
       Region 5m6x A 258-431 order
       Region 5m6x A 432-437 disorder
Seq 198-439 Monomer :
 Evidence X-RAY 1rgp A Reference
       Region 1rgp A 198-232 disorder
       Region 1rgp A 233-402 order
       Region 1rgp A 403-412 disorder
       Region 1rgp A 413-431 order
       Region 1rgp A 432-439 disorder
Seq 206-439 Hetero dimer : IID00308Complex
 Evidence X-RAY 2ngr B Reference
       Region 2ngr B 206-236 disorder
       Region 2ngr B 237-432 order
       Region 2ngr B 433-439 disorder
 Evidence X-RAY 1grn B Reference
       Region 1grn B 237-433 order
       Region 1grn B 434-439 disorder
 Evidence X-RAY 1am4 B Reference
       Region 1am4 B 233-431 order
 Evidence X-RAY 1am4 C Reference
       Region 1am4 C 233-431 order
 Evidence X-RAY 1am4 A Reference
       Region 1am4 A 233-431 order
SeqProS verified 403-412 Hetero dimer : IID00274Complex
       Region 1tx4 A 236-431 order
       Region 1ow3 A 236-431 order
       Region 1rgp A 403-412 disorder
SeqProS verified 403-412 Hetero dimer : IID00308Complex
       Region 2ngr B 237-432 order
       Region 1grn B 237-433 order
       Region 1am4 A 233-431 order
       Region 1am4 B 233-431 order
       Region 1am4 C 233-431 order
       Region 1rgp A 403-412 disorder
Seqphosphorylation
    47-47 Phosphoserine
    44-44 Phosphoserine
    50-50 Phosphoserine
    51-51 Phosphoserine
    65-65 Phosphotyrosine
Seqacetylation
    1-1 N-acetylmethionine
    80-80 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-57,223-244,436-439
Order 58-222,245-435
ProS 1-18,21-27,39-43,223-244,436-439
AlphaFold
Disorder 1-56,222-235,405-411,434-439
Order 57-221,236-404,412-433
Pfam Hmmer
PF00620 260-408 5.4e-62
SEG 42-52 ,224-238
Function
Function in SwissProt
GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.