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IID00317
 UniprotQ09028
ProteinHistone-binding protein RBBP4
GeneRBBP4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
425
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-425 Hetero tetramer : IID00725Complex,Q6ZN18
 Evidence X-RAY 5wai E Reference
       Region 5wai E 1-3 disorder
       Region 5wai E 4-92 order
       Region 5wai E 93-106 disorder
       Region 5wai E 107-210 order
       Region 5wai E 211-214 disorder
       Region 5wai E 215-412 order
       Region 5wai E 413-425 disorder
Seq 1-425 Hetero dimer : Q9HAZ2
 Evidence X-RAY 6bw4 A Reference
       Region 6bw4 A 1-4 disorder
       Region 6bw4 A 5-88 order
       Region 6bw4 A 89-113 disorder
       Region 6bw4 A 114-355 order
       Region 6bw4 A 356-359 disorder
       Region 6bw4 A 360-410 order
       Region 6bw4 A 411-425 disorder
 Evidence X-RAY 6bw4 C Reference
       Region 6bw4 C 1-8 disorder
       Region 6bw4 C 9-88 order
       Region 6bw4 C 89-112 disorder
       Region 6bw4 C 113-209 order
       Region 6bw4 C 210-213 disorder
       Region 6bw4 C 214-355 order
       Region 6bw4 C 356-359 disorder
       Region 6bw4 C 360-410 order
       Region 6bw4 C 411-425 disorder
Seq 1-425 Hetero tetramer : IID00563Complex
 Evidence X-RAY 4pby A Reference
       Region 4pby A 1-2 disorder
       Region 4pby A 3-88 order
       Region 4pby A 89-113 disorder
       Region 4pby A 114-411 order
       Region 4pby A 412-425 disorder
 Evidence X-RAY 4pby B Reference
       Region 4pby B 1-7 disorder
       Region 4pby B 8-410 order
       Region 4pby B 411-425 disorder
Seq 1-425 Hetero dimer : Q9H165
 Evidence X-RAY 5vtb A Reference
       Region 5vtb A 1-24 disorder
       Region 5vtb A 25-54 order
       Region 5vtb A 55-58 disorder
       Region 5vtb A 59-88 order
       Region 5vtb A 89-112 disorder
       Region 5vtb A 113-352 order
       Region 5vtb A 353-362 disorder
       Region 5vtb A 363-411 order
       Region 5vtb A 412-425 disorder
Seq 1-425 Hetero dimer : IID00594Complex
 Evidence X-RAY 4r7a B Reference
       Region 4r7a B 1-14 disorder
       Region 4r7a B 15-88 order
       Region 4r7a B 89-113 disorder
       Region 4r7a B 114-353 order
       Region 4r7a B 354-358 disorder
       Region 4r7a B 359-410 order
       Region 4r7a B 411-425 disorder
Seq 1-425 Hetero tetramer : IID00725Complex,Q6ZN18
 Evidence X-RAY 5wai A Reference
       Region 5wai A 1-2 disorder
       Region 5wai A 3-93 order
       Region 5wai A 94-104 disorder
       Region 5wai A 105-211 order
       Region 5wai A 212-213 disorder
       Region 5wai A 214-412 order
       Region 5wai A 413-425 disorder
Seq 1-425 Hetero dimer : IID00725Complex
 Evidence X-RAY 5wak A Reference
       Region 5wak A 1-7 disorder
       Region 5wak A 8-97 order
       Region 5wak A 98-110 disorder
       Region 5wak A 111-412 order
       Region 5wak A 413-425 disorder
Seq 1-425 Hetero dimer : IID00563Complex
 Evidence X-RAY 5fxy E Reference
       Region 5fxy E 1-9 disorder
       Region 5fxy E 10-89 order
       Region 5fxy E 90-102 disorder
       Region 5fxy E 103-163 order
       Region 5fxy E 164-165 disorder
       Region 5fxy E 166-175 order
       Region 5fxy E 176-179 disorder
       Region 5fxy E 180-210 order
       Region 5fxy E 211-213 disorder
       Region 5fxy E 214-411 order
       Region 5fxy E 412-425 disorder
 Evidence X-RAY 5fxy G Reference
       Region 5fxy G 1-9 disorder
       Region 5fxy G 10-89 order
       Region 5fxy G 90-102 disorder
       Region 5fxy G 103-163 order
       Region 5fxy G 164-165 disorder
       Region 5fxy G 166-175 order
       Region 5fxy G 176-179 disorder
       Region 5fxy G 180-211 order
       Region 5fxy G 212-213 disorder
       Region 5fxy G 214-411 order
       Region 5fxy G 412-425 disorder
 Evidence X-RAY 5fxy C Reference
       Region 5fxy C 1-9 disorder
       Region 5fxy C 10-89 order
       Region 5fxy C 90-102 disorder
       Region 5fxy C 103-163 order
       Region 5fxy C 164-165 disorder
       Region 5fxy C 166-175 order
       Region 5fxy C 176-179 disorder
       Region 5fxy C 180-210 order
       Region 5fxy C 211-213 disorder
       Region 5fxy C 214-411 order
       Region 5fxy C 412-425 disorder
 Evidence X-RAY 5fxy A Reference
       Region 5fxy A 1-9 disorder
       Region 5fxy A 10-89 order
       Region 5fxy A 90-102 disorder
       Region 5fxy A 103-163 order
       Region 5fxy A 164-165 disorder
       Region 5fxy A 166-175 order
       Region 5fxy A 176-179 disorder
       Region 5fxy A 180-211 order
       Region 5fxy A 212-213 disorder
       Region 5fxy A 214-411 order
       Region 5fxy A 412-425 disorder
Seq 1-425 Hetero dimer : Q03112
 Evidence X-RAY 6bw3 A Reference
       Region 6bw3 A 1-8 disorder
       Region 6bw3 A 9-89 order
       Region 6bw3 A 90-113 disorder
       Region 6bw3 A 114-355 order
       Region 6bw3 A 356-359 disorder
       Region 6bw3 A 360-410 order
       Region 6bw3 A 411-425 disorder
 Evidence X-RAY 6bw3 C Reference
       Region 6bw3 C 1-9 disorder
       Region 6bw3 C 10-88 order
       Region 6bw3 C 89-112 disorder
       Region 6bw3 C 113-209 order
       Region 6bw3 C 210-213 disorder
       Region 6bw3 C 214-355 order
       Region 6bw3 C 356-359 disorder
       Region 6bw3 C 360-410 order
       Region 6bw3 C 411-425 disorder
Seq 1-425 Monomer :
 Evidence X-RAY 3gfc A Reference
       Region 3gfc A 1-23 disorder
       Region 3gfc A 24-54 order
       Region 3gfc A 55-59 disorder
       Region 3gfc A 60-72 order
       Region 3gfc A 73-75 disorder
       Region 3gfc A 76-88 order
       Region 3gfc A 89-113 disorder
       Region 3gfc A 114-162 order
       Region 3gfc A 163-166 disorder
       Region 3gfc A 167-351 order
       Region 3gfc A 352-362 disorder
       Region 3gfc A 363-410 order
       Region 3gfc A 411-425 disorder
Seq 1-425 Hetero dimer : IID00324Complex
 Evidence X-RAY 2xu7 B Reference
       Region 2xu7 B 1-10 disorder
       Region 2xu7 B 11-88 order
       Region 2xu7 B 89-113 disorder
       Region 2xu7 B 114-352 order
       Region 2xu7 B 353-360 disorder
       Region 2xu7 B 361-410 order
       Region 2xu7 B 411-425 disorder
 Evidence X-RAY 2xu7 A Reference
       Region 2xu7 A 1-15 disorder
       Region 2xu7 A 16-54 order
       Region 2xu7 A 55-60 disorder
       Region 2xu7 A 61-88 order
       Region 2xu7 A 89-113 disorder
       Region 2xu7 A 114-355 order
       Region 2xu7 A 356-359 disorder
       Region 2xu7 A 360-410 order
       Region 2xu7 A 411-425 disorder
Seq 1-425 Hetero dimer : IID00563Complex
 Evidence X-RAY 4pc0 B Reference
       Region 4pc0 B 1-6 disorder
       Region 4pc0 B 7-410 order
       Region 4pc0 B 411-425 disorder
 Evidence X-RAY 4pc0 A Reference
       Region 4pc0 A 1-9 disorder
       Region 4pc0 A 10-411 order
       Region 4pc0 A 412-425 disorder
 Evidence X-RAY 4pbz A Reference
       Region 4pbz A 1-1 disorder
       Region 4pbz A 2-89 order
       Region 4pbz A 90-113 disorder
       Region 4pbz A 114-411 order
       Region 4pbz A 412-425 disorder
Seqphosphorylation
    110-110 Phosphoserine
    355-355 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
    4-4 N6-acetyllysine; alternate
    160-160 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-13,92-109,412-425
Order 14-91,110-411
ProS 92-97,105-109
AlphaFold
Disorder 1-7,91-113,411-425
Order 8-90,114-410
Pfam Hmmer
PF00400 167-206 7e-08
PF00400 217-256 8.4e-05
PF00400 263-302 1.1e-09
PF00400 307-346 5.8e-07
PF00400 364-403 6.5e-06
Function
Function in SwissProt
Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
Biological Process
See also
Diagram with PDB data
MTA1/HDAC1The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex
SUZ12/RBBP4/PHF19/JARID2Crystal Structure of a SUZ12-RBBP4-PHF19-JARID2 Heterotetrameric Complex
EZH2/EED/SUZ12/H3C1/JARID2Structure of Human Polycomb Repressive Complex 2 (PRC2) with oncogenic histone H3K27M peptide