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IID00321
 UniprotQ13309
ProteinS-phase kinase-associated protein 2
GeneSKP2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
424
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 89-141 Hetero tetramer : P63208
 Evidence X-RAY 1fs1 C Reference
       Region 1fs1 C 89-96 disorder
       Region 1fs1 C 97-137 order
       Region 1fs1 C 138-141 disorder
 Evidence X-RAY 1fs1 A Reference
       Region 1fs1 A 89-96 disorder
       Region 1fs1 A 97-137 order
       Region 1fs1 A 138-141 disorder
Seq 89-141,180-398 Hetero tetramer : P63208
 Evidence X-RAY 1fs2 C Reference
       Region 1fs2 C 89-92 disorder
       Region 1fs2 C 93-141 order
       Region 1fs2 C 180-389 order
       Region 1fs2 C 390-398 disorder
 Evidence X-RAY 1fs2 A Reference
       Region 1fs2 A 89-92 disorder
       Region 1fs2 A 93-141 order
       Region 1fs2 A 180-389 order
       Region 1fs2 A 390-398 disorder
Seq 89-424 Hetero trimer : IID00309Complex,P63208
 Evidence X-RAY 2ass B Reference
       Region 2ass B 89-94 disorder
       Region 2ass B 95-419 order
       Region 2ass B 420-424 disorder
Seq 89-424 Hetero tetramer : IID00049Complex,IID00309Complex,P63208
 Evidence X-RAY 2ast B Reference
       Region 2ast B 89-94 disorder
       Region 2ast B 95-419 order
       Region 2ast B 420-424 disorder
Seq 89-424 Hetero dimer : P63208
 Evidence X-RAY 1fqv O Reference
       Region 1fqv O 89-94 disorder
       Region 1fqv O 95-419 order
       Region 1fqv O 420-424 disorder
 Evidence X-RAY 1fqv M Reference
       Region 1fqv M 89-94 disorder
       Region 1fqv M 95-419 order
       Region 1fqv M 420-424 disorder
 Evidence X-RAY 1fqv K Reference
       Region 1fqv K 89-94 disorder
       Region 1fqv K 95-419 order
       Region 1fqv K 420-424 disorder
 Evidence X-RAY 1fqv I Reference
       Region 1fqv I 89-94 disorder
       Region 1fqv I 95-419 order
       Region 1fqv I 420-424 disorder
 Evidence X-RAY 1fqv G Reference
       Region 1fqv G 89-94 disorder
       Region 1fqv G 95-419 order
       Region 1fqv G 420-424 disorder
 Evidence X-RAY 1fqv E Reference
       Region 1fqv E 89-94 disorder
       Region 1fqv E 95-419 order
       Region 1fqv E 420-424 disorder
 Evidence X-RAY 1fqv C Reference
       Region 1fqv C 89-94 disorder
       Region 1fqv C 95-419 order
       Region 1fqv C 420-424 disorder
 Evidence X-RAY 1fqv A Reference
       Region 1fqv A 89-94 disorder
       Region 1fqv A 95-419 order
       Region 1fqv A 420-424 disorder
Seq 97-137 Hetero pentamer : IID00133Complex,P63208
 Evidence X-RAY 1ldk E Reference
       Region 1ldk E 97-137 order
Seqphosphorylation
    64-64 Phosphoserine
    72-72 Phosphoserine
    75-75 Phosphoserine
    179-179 Phosphoserine
Seqacetylation
    68-68 N6-acetyllysine; by p300/EP300
    71-71 N6-acetyllysine; by p300/EP300
 
Prediction
NeProc
Disorder 1-90
Order 91-424
ProS 1-25,31-56,75-83
AlphaFold
Disorder 1-93,403-405,419-424
Order 94-402,406-418
Pfam Hmmer
PF00646 95-142 7.2e-11
Function
Function in SwissProt
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:17962192, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219).
Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus.
Biological Process
See also
Diagram with PDB data
CDKN1B/SKP1/SKP2/CKS1BCrystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide