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IID00324
 UniprotQ8IX07
ProteinZinc finger protein ZFPM1
GeneZFPM1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1006
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-15 Hetero dimer : IID00317Complex
 Evidence X-RAY 2xu7 C Reference
       Region 2xu7 C 1-1 disorder
       Region 2xu7 C 2-13 order
       Region 2xu7 C 14-15 disorder
 Evidence X-RAY 2xu7 D Reference
       Region 2xu7 D 1-13 order
       Region 2xu7 D 14-15 disorder
SeqProS predicted 1-13 The unbound state of this region is predicted to be disordered by DICHOT and MobiDB. Hetero dimer : IID00317Complex
       Region 2xu7 C 2-13 order
       Region 2xu7 D 1-13 order
Seqphosphorylation
    671-671 Phosphoserine
    84-84 Phosphoserine
    128-128 Phosphoserine
    272-272 Phosphoserine
    384-384 Phosphoserine
    491-491 Phosphoserine
    494-494 Phosphoserine
    638-638 Phosphoserine
    786-786 Phosphoserine
    901-901 Phosphoserine
    909-909 Phosphoserine
    914-914 Phosphoserine
    935-935 Phosphoserine
 
Prediction
NeProc
Disorder 1-169,180-185,193-972
Order 170-179,186-192,973-1006
ProS 5-22,84-124,136-152,161-169,180-185,211-223,235-266,285-299,306-313,319-336,345-366,578-582,793-796,867-871
AlphaFold
Disorder 1-85,125-137,192-220,228-239,266-289,345-345,376-537,539-539,554-554,556-576,601-679,707-816,842-855,857-858,860-867,878-973,998-1006
Order 86-124,138-191,221-227,240-265,290-344,346-375,538-538,540-553,555-555,577-600,680-706,817-841,856-856,859-859,868-877,974-997
Pfam Hmmer
PF00096 290-314 0.00085
SEG 37-65 ,72-85 ,464-474 ,483-499 ,505-516 ,555-566 ,603-632 ,639-660 ,712-744 ,750-791 ,801-814 ,840-864 ,878-889 ,895-917 ,923-950
Function
Function in SwissProt
Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity).