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IID00326
 UniprotQ96QT6
ProteinPHD finger protein 12
GenePHF12
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1004
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 200-241 Hetero dimer : IID50089Complex
 Evidence NMR 2l9s A Reference
       Region 2l9s A 200-241 order
       Region 2l9s A 200-206 high_rmsd
       Region 2l9s A 227-241 high_rmsd
Seqdisorder 200-241
 Evidence NMR Reference
       Region 200-241 disorder
Seq 200-241 Hetero dimer : IID00330Complex
 Evidence NMR 2lkm A Reference
       Region 2lkm A 200-241 order
       Region 2lkm A 200-201 high_rmsd
       Region 2lkm A 236-241 high_rmsd
SeqProS verified 200-241 Hetero dimer : IID00330Complex
       Region 2lkm A 200-241 order
       Region 200-241 disorder
SeqProS verified 200-241 Hetero dimer : IID50089Complex
       Region 2l9s A 200-241 order
       Region 200-241 disorder
Seqphosphorylation
    131-131 Phosphoserine
    134-134 Phosphoserine
    555-555 Phosphoserine
    557-557 Phosphothreonine
    570-570 Phosphothreonine
    671-671 Phosphothreonine
 
Prediction
NeProc
Disorder 1-51,94-206,243-259,364-724,765-784,891-923,974-1004
Order 52-93,207-242,260-363,725-764,785-877,884-890,924-973
ProS 1-29,46-51,94-139,146-206,243-259,364-406,430-449,517-524,533-541,546-552,595-602,695-702,718-724,891-897,915-923,984-987,993-1004
AlphaFold
Disorder 1-21,30-30,32-53,91-91,93-94,114-207,222-269,323-329,331-331,333-335,337-345,363-377,391-391,393-424,450-745,748-748,761-791,803-803,873-882,899-923,932-940,966-1004
Order 22-29,31-31,54-90,92-92,95-113,208-221,270-322,330-330,332-332,336-336,346-362,378-390,392-392,425-449,746-747,749-760,792-802,804-872,883-898,924-931,941-965
Pfam Hmmer
PF00628 58-105 3.8e-12
PF00628 273-321 4.5e-07
SEG 37-50 ,166-179 ,182-193 ,617-631 ,906-917 ,928-940
Function
Function in SwissProt
Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA.
Biological Process
Diagram with PDB data
PHF12/MORF4L1Structural Basis for Molecular Interactions Involving MRG Domains: Implications in Chromatin Biology