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IID00328
 UniprotQ9HCE7
ProteinE3 ubiquitin-protein ligase SMURF1
GeneSMURF1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
757
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 13-140 Monomer :
 Evidence X-RAY 3pyc A Reference
       Region 3pyc A 13-140 order
Seq 235-267 Hetero dimer : IID00174Complex
 Evidence NMR 2laz A Reference
       Region 2laz A 235-267 order
 Evidence NMR 2lb0 A Reference
       Region 2lb0 A 235-267 order
Seq 305-340 Hetero dimer : IID00174Complex
 Evidence NMR 2lb1 A Reference
       Region 2lb1 A 305-339 order
       Region 2lb1 A 340-340 disorder
Seq 306-340 Hetero dimer : IID00135Complex
 Evidence NMR 2ltx A Reference
       Region 2ltx A 306-340 order
       Region 2ltx A 306-306 high_rmsd
Seqphosphorylation
    200-200 Phosphoserine
 
Prediction
NeProc
Disorder 1-12,120-235,242-323,343-368
Order 13-119,236-241,324-342,369-757
ProS 120-142,242-268,303-323,343-346,363-368
AlphaFold
Disorder 1-11,30-31,88-88,112-112,141-235,246-249,258-260,267-305,318-320,335-335,340-376,436-441,459-459,467-471,481-482,561-564,698-702,751-757
Order 12-29,32-87,89-111,113-140,236-245,250-257,261-266,306-317,321-334,336-339,377-435,442-458,460-466,472-480,483-560,565-697,703-750
Pfam Hmmer
PF00168 15-99 3.5e-21
PF00397 236-265 7.9e-10
PF00397 308-337 1.4e-13
PF00632 449-757 1.7e-176
Function
Function in SwissProt
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Biological Process
See also
Diagram with PDB data
SMAD7/SMURF2Solution structure of Smurf2 WW3 domain-Smad7 PY peptide complex
SMAD1/YAP1Structure of the first WW domain of human YAP in complex with a phosphorylated human Smad1 derived peptide