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IID00329
 UniprotQ9NRG4
ProteinN-lysine methyltransferase SMYD2
GeneSMYD2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
433
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-433 Monomer :
 Evidence X-RAY 3rib A Reference
       Region 3rib A 1-6 disorder
       Region 3rib A 7-433 order
 Evidence X-RAY 3rib B Reference
       Region 3rib B 1-6 disorder
       Region 3rib B 7-280 order
       Region 3rib B 281-287 disorder
       Region 3rib B 288-331 order
       Region 3rib B 332-336 disorder
       Region 3rib B 337-433 order
 Evidence X-RAY 3s7b A Reference
       Region 3s7b A 1-4 disorder
       Region 3s7b A 5-433 order
 Evidence X-RAY 3s7j A Reference
       Region 3s7j A 1-5 disorder
       Region 3s7j A 6-433 order
 Evidence X-RAY 3tg4 A Reference
       Region 3tg4 A 1-5 disorder
       Region 3tg4 A 6-432 order
       Region 3tg4 A 433-433 disorder
 Evidence X-RAY 4wuy A Reference
       Region 4wuy A 1-4 disorder
       Region 4wuy A 5-280 order
       Region 4wuy A 281-286 disorder
       Region 4wuy A 287-306 order
       Region 4wuy A 307-315 disorder
       Region 4wuy A 316-433 order
 Evidence X-RAY 4ynd A Reference
       Region 4ynd A 1-2 disorder
       Region 4ynd A 3-430 order
       Region 4ynd A 431-433 disorder
 Evidence X-RAY 5arf A Reference
       Region 5arf A 2-5 disorder
       Region 5arf A 6-430 order
       Region 5arf A 431-433 disorder
 Evidence X-RAY 5arg A Reference
       Region 5arg A 2-5 disorder
       Region 5arg A 6-431 order
       Region 5arg A 432-433 disorder
 Evidence X-RAY 5kjk A Reference
       Region 5kjk A 5-433 order
 Evidence X-RAY 5kjl A Reference
       Region 5kjl A 5-5 disorder
       Region 5kjl A 6-433 order
 Evidence X-RAY 5kjm A Reference
       Region 5kjm A 5-433 order
 Evidence X-RAY 5kjn A Reference
       Region 5kjn A 5-433 order
 Evidence X-RAY 5wcg A Reference
       Region 5wcg A 1-1 disorder
       Region 5wcg A 2-4 order
       Region 5wcg A 5-5 disorder
       Region 5wcg A 6-432 order
       Region 5wcg A 433-433 disorder
 Evidence X-RAY 6cbx A Reference
       Region 6cbx A 1-4 disorder
       Region 6cbx A 5-432 order
       Region 6cbx A 433-433 disorder
 Evidence X-RAY 6cbx B Reference
       Region 6cbx B 1-432 order
       Region 6cbx B 433-433 disorder
 Evidence X-RAY 6cby A Reference
       Region 6cby A 1-4 disorder
       Region 6cby A 5-432 order
       Region 6cby A 433-433 disorder
 Evidence X-RAY 6cby B Reference
       Region 6cby B 1-4 disorder
       Region 6cby B 5-279 order
       Region 6cby B 280-286 disorder
       Region 6cby B 287-433 order
Seq 1-433 Hetero dimer : IID00013Complex
 Evidence X-RAY 4o6f A Reference
       Region 4o6f A 1-2 disorder
       Region 4o6f A 3-432 order
       Region 4o6f A 433-433 disorder
Seq 1-433 Hetero dimer :
 Evidence X-RAY 3s7f A Reference
       Region 3s7f A 1-4 disorder
       Region 3s7f A 5-433 order
Seq 1-433 Hetero dimer :
 Evidence X-RAY 3s7d A Reference
       Region 3s7d A 1-4 disorder
       Region 3s7d A 5-433 order
Seq 1-433 Hetero dimer : IID00015Complex
 Evidence X-RAY 3tg5 A Reference
       Region 3tg5 A 1-5 disorder
       Region 3tg5 A 6-430 order
       Region 3tg5 A 431-433 disorder
Seqphosphorylation
    283-283 Phosphoserine
 
Prediction
NeProc
Disorder 1-5,284-289
Order 6-283,290-433
ProS 284-289
AlphaFold
Disorder 1-4
Order 5-433
Pfam Hmmer
PF01753 52-90 4.4e-11
Function
Function in SwissProt
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
Biological Process
See also
Diagram with PDB data
ESR1/SMYD2Structural Basis of Estrogen Receptor Alpha Methylation Mediated by Histone Methyltransferase SmyD2
TP53/SMYD2Structure of SMYD2 in complex with p53 and SAH