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IID00330
 UniprotQ9UBU8
ProteinMortality factor 4-like protein 1
GeneMORF4L1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
362
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-51,91-129 Homo trimer :
 Evidence X-RAY 2f5k A Reference
       Region 2f5k A 1-5 disorder
       Region 2f5k A 6-51 order
       Region 2f5k A 91-127 order
       Region 2f5k A 128-129 disorder
 Evidence X-RAY 2f5k B Reference
       Region 2f5k B 1-5 disorder
       Region 2f5k B 6-51 order
       Region 2f5k B 91-129 order
 Evidence X-RAY 2f5k C Reference
       Region 2f5k C 1-6 disorder
       Region 2f5k C 7-51 order
       Region 2f5k C 91-125 order
       Region 2f5k C 126-129 disorder
 Evidence X-RAY 2f5k D Reference
       Region 2f5k D 1-5 disorder
       Region 2f5k D 6-51 order
       Region 2f5k D 91-123 order
       Region 2f5k D 124-129 disorder
 Evidence X-RAY 2f5k E Reference
       Region 2f5k E 1-5 disorder
       Region 2f5k E 6-51 order
       Region 2f5k E 91-122 order
       Region 2f5k E 123-129 disorder
 Evidence X-RAY 2f5k F Reference
       Region 2f5k F 1-8 disorder
       Region 2f5k F 9-51 order
       Region 2f5k F 91-125 order
       Region 2f5k F 126-129 disorder
Seq 1-51,89-132 Monomer :
 Evidence NMR 2efi A Reference
       Region 2efi A 1-4 high_rmsd
       Region 2efi A 1-51 order
       Region 2efi A 89-93 high_rmsd
       Region 2efi A 91-132 order
Seq 190-362 Homo dimer :
 Evidence X-RAY 2aql A Reference
       Region 2aql A 190-193 disorder
       Region 2aql A 194-240 order
       Region 2aql A 241-249 disorder
       Region 2aql A 250-360 order
       Region 2aql A 361-362 disorder
 Evidence X-RAY 2aql B Reference
       Region 2aql B 190-195 disorder
       Region 2aql B 196-240 order
       Region 2aql B 241-251 disorder
       Region 2aql B 252-358 order
       Region 2aql B 359-362 disorder
 Evidence X-RAY 2f5j A Reference
       Region 2f5j A 190-194 disorder
       Region 2f5j A 195-242 order
       Region 2f5j A 243-250 disorder
       Region 2f5j A 251-359 order
       Region 2f5j A 360-360 disorder
 Evidence X-RAY 2f5j B Reference
       Region 2f5j B 190-194 disorder
       Region 2f5j B 195-243 order
       Region 2f5j B 244-250 disorder
       Region 2f5j B 251-360 order
Seq 194-362 Hetero dimer : Q9NV56
 Evidence NMR 2n1d B Reference
       Region 2n1d B 194-362 order
Seq 194-362 Hetero dimer : IID00326Complex
 Evidence NMR 2lkm B Reference
       Region 2lkm B 194-362 order
Seqacetylation
    143-143 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-9,59-82,115-188,244-247
Order 10-58,83-114,189-243,248-362
ProS 79-82,115-123,145-152,174-188,244-247
AlphaFold
Disorder 1-5,48-92,122-194,244-247
Order 6-47,93-121,195-243,248-362
Pfam Hmmer
PF05712 90-350 2.5e-133
Function
Function in SwissProt
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.
Biological Process
See also
Diagram with PDB data
PHF12/MORF4L1Structural Basis for Molecular Interactions Involving MRG Domains: Implications in Chromatin Biology