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IID00332
 UniprotQ9UIS9
ProteinMethyl-CpG-binding domain protein 1
GeneMBD1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
605
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-75 Monomer :
 Evidence NMR 1d9n A Reference
       Region 1d9n A 1-75 order
 Evidence NMR 1ig4 A Reference
       Region 1ig4 A 1-75 order
       Region 1ig4 A 1-1 high_rmsd
       Region 1ig4 A 72-75 high_rmsd
Seqdisorder 22-29
 Evidence NMR Reference
       Region 22-29 disorder
Seq 167-222 Monomer :
 Evidence NMR 4d4w A Reference
       Region 4d4w A 167-222 order
       Region 4d4w A 167-173 high_rmsd
       Region 4d4w A 199-206 high_rmsd
       Region 4d4w A 220-222 high_rmsd
Seq 330-388 Monomer :
 Evidence X-RAY 5w9q A Reference
       Region 5w9q A 330-332 disorder
       Region 5w9q A 333-388 order
 Evidence X-RAY 5w9q B Reference
       Region 5w9q B 330-333 disorder
       Region 5w9q B 334-339 order
       Region 5w9q B 340-340 disorder
       Region 5w9q B 341-388 order
SeqProS verified 22-29 This region is ordered in the complex with DNA. :
       Region 1ig4 A 1-75 order
       Region 22-29 disorder
Seqphosphorylation
    297-297 Phosphoserine
    391-391 Phosphoserine
    399-399 Phosphoserine
 
Prediction
NeProc
Disorder 78-217,253-344,349-576,598-605
Order 1-77,218-252,345-348,577-597
ProS 78-84,128-144,150-196,207-217,253-295,304-327,338-344,349-379,442-447,451-460,468-472,522-529,569-576
AlphaFold
Disorder 1-2,73-131,141-151,220-224,251-253,264-335,388-605
Order 3-72,132-140,152-219,225-250,254-263,336-387
Pfam Hmmer
PF01429 1-72 5.1e-23
PF02008 168-215 7.3e-17
PF02008 217-262 9.1e-20
PF02008 330-377 2.2e-21
SEG 82-98 ,284-305 ,399-414 ,538-554
Function
Function in SwissProt
Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
Biological Process
Diagram with PDB data
MBD1/DNASolution Structure of the Methyl-CpG-Binding Domain of Human MBD1 in Complex with Methylated DNA