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IID00333
 UniprotQ9ULH1
ProteinArf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
GeneASAP1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1129
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 323-423 Monomer :
 Evidence NMR 2da0 A Reference
       Region 2da0 A 323-423 order
       Region 2da0 A 360-362 high_rmsd
Seq 823-837 Hetero trimer : Q14247
 Evidence X-RAY 2d1x P Reference
       Region 2d1x P 823-824 disorder
       Region 2d1x P 825-833 order
       Region 2d1x P 834-837 disorder
 Evidence X-RAY 2d1x Q Reference
       Region 2d1x Q 823-824 disorder
       Region 2d1x Q 825-833 order
       Region 2d1x Q 834-837 disorder
Seq 1067-1129 Monomer :
 Evidence NMR 2ed1 A Reference
       Region 2ed1 A 1067-1129 order
 Evidence NMR 2rqt A Reference
       Region 2rqt A 1069-1129 order
Seq 1069-1129 Hetero dimer : IID00035Complex
 Evidence NMR 2rqu A Reference
       Region 2rqu A 1069-1129 order
SeqProS possible 825-833 SH3 binding region (Pro rich) Hetero trimer : Q14247
       Region 2d1x P 825-833 order
       Region 2d1x Q 825-833 order
Seqphosphorylation
    1128-1128 Phosphoserine
    1048-1048 Phosphothreonine
    1041-1041 Phosphoserine
    1027-1027 Phosphoserine
    1008-1008 Phosphoserine
    843-843 Phosphoserine
    839-839 Phosphoserine
    726-726 Phosphoserine
    717-717 Phosphoserine
 
Prediction
NeProc
Disorder 1-13,184-197,298-317,425-435,712-1068
Order 14-183,198-297,318-424,436-711,1069-1129
ProS 4-13,184-197,298-317,432-435,723-729,737-741,889-937,967-974
AlphaFold
Disorder 1-22,190-199,298-318,424-432,595-597,710-1068,1129-1129
Order 23-189,200-297,319-423,433-594,598-709,1069-1128
Pfam Hmmer
PF00169 325-416 5.6e-15
PF01412 439-562 2e-37
PF00023 600-635 0.00051
PF00018 1070-1127 1.6e-11
SEG 2-16 ,122-136 ,147-164 ,524-534 ,588-602 ,712-730 ,777-795 ,799-825 ,827-832 ,841-850 ,876-889 ,930-943 ,955-969 ,1047-1059 ,1089-1100
Function
Function in SwissProt
Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis.