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IID00335
 UniprotQ9Y468
ProteinLethal(3)malignant brain tumor-like protein 1
GeneL3MBTL1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
840
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 259-598 Homo trimer :
 Evidence X-RAY 3oq5 A Reference
       Region 3oq5 A 259-273 disorder
       Region 3oq5 A 274-377 order
       Region 3oq5 A 378-381 disorder
       Region 3oq5 A 382-586 order
       Region 3oq5 A 587-598 disorder
 Evidence X-RAY 3oq5 B Reference
       Region 3oq5 B 259-273 disorder
       Region 3oq5 B 274-377 order
       Region 3oq5 B 378-381 disorder
       Region 3oq5 B 382-586 order
       Region 3oq5 B 587-598 disorder
 Evidence X-RAY 3oq5 C Reference
       Region 3oq5 C 259-273 disorder
       Region 3oq5 C 274-377 order
       Region 3oq5 C 378-381 disorder
       Region 3oq5 C 382-586 order
       Region 3oq5 C 587-598 disorder
Seq 265-594 Hetero dimer : IID00028Complex
 Evidence X-RAY 2rhi A Reference
       Region 2rhi A 265-272 disorder
       Region 2rhi A 273-594 order
Seq 265-595 Homo nonamer :
 Evidence X-RAY 1oyx A Reference
       Region 1oyx A 265-273 disorder
       Region 1oyx A 274-586 order
       Region 1oyx A 587-595 disorder
 Evidence X-RAY 1oyx B Reference
       Region 1oyx B 265-273 disorder
       Region 1oyx B 274-586 order
       Region 1oyx B 587-595 disorder
 Evidence X-RAY 1oyx C Reference
       Region 1oyx C 265-273 disorder
       Region 1oyx C 274-586 order
       Region 1oyx C 587-595 disorder
 Evidence X-RAY 1oz3 A Reference
       Region 1oz3 A 265-273 disorder
       Region 1oz3 A 274-586 order
       Region 1oz3 A 587-595 disorder
 Evidence X-RAY 1oz3 B Reference
       Region 1oz3 B 265-273 disorder
       Region 1oz3 B 274-586 order
       Region 1oz3 B 587-595 disorder
 Evidence X-RAY 1oz3 C Reference
       Region 1oz3 C 265-273 disorder
       Region 1oz3 C 274-586 order
       Region 1oz3 C 587-595 disorder
Seq 265-598 Monomer :
 Evidence X-RAY 1oz2 A Reference
       Region 1oz2 A 265-271 disorder
       Region 1oz2 A 272-595 order
 Evidence X-RAY 2rhu A Reference
       Region 2rhu A 274-587 order
 Evidence X-RAY 2rhx A Reference
       Region 2rhx A 265-271 disorder
       Region 2rhx A 272-594 order
 Evidence X-RAY 2rhy A Reference
       Region 2rhy A 274-587 order
 Evidence X-RAY 2rhz A Reference
       Region 2rhz A 274-587 order
 Evidence X-RAY 2ri2 A Reference
       Region 2ri2 A 274-587 order
 Evidence X-RAY 2ri3 A Reference
       Region 2ri3 A 274-587 order
 Evidence X-RAY 2ri5 A Reference
       Region 2ri5 A 274-587 order
 Evidence X-RAY 2rjc A Reference
       Region 2rjc A 268-273 disorder
       Region 2rjc A 274-586 order
       Region 2rjc A 587-598 disorder
 Evidence X-RAY 2rjc B Reference
       Region 2rjc B 268-272 disorder
       Region 2rjc B 273-377 order
       Region 2rjc B 378-381 disorder
       Region 2rjc B 382-590 order
       Region 2rjc B 591-598 disorder
 Evidence X-RAY 2rjc C Reference
       Region 2rjc C 268-273 disorder
       Region 2rjc C 274-377 order
       Region 2rjc C 378-380 disorder
       Region 2rjc C 381-484 order
       Region 2rjc C 485-489 disorder
       Region 2rjc C 490-587 order
       Region 2rjc C 588-598 disorder
 Evidence X-RAY 2rjd A Reference
       Region 2rjd A 268-271 disorder
       Region 2rjd A 272-403 order
       Region 2rjd A 404-407 disorder
       Region 2rjd A 408-596 order
       Region 2rjd A 597-598 disorder
 Evidence X-RAY 3p8h A Reference
       Region 3p8h A 268-273 disorder
       Region 3p8h A 274-586 order
       Region 3p8h A 587-590 disorder
 Evidence X-RAY 3p8h B Reference
       Region 3p8h B 268-273 disorder
       Region 3p8h B 274-377 order
       Region 3p8h B 378-381 disorder
       Region 3p8h B 382-587 order
       Region 3p8h B 588-590 disorder
 Evidence X-RAY 3p8h C Reference
       Region 3p8h C 268-273 disorder
       Region 3p8h C 274-378 order
       Region 3p8h C 379-380 disorder
       Region 3p8h C 381-587 order
       Region 3p8h C 588-590 disorder
 Evidence X-RAY 3uwn A Reference
       Region 3uwn A 268-271 disorder
       Region 3uwn A 272-403 order
       Region 3uwn A 404-407 disorder
       Region 3uwn A 408-487 order
       Region 3uwn A 488-489 disorder
       Region 3uwn A 490-595 order
       Region 3uwn A 596-598 disorder
 Evidence X-RAY 6byb A Reference
       Region 6byb A 268-271 disorder
       Region 6byb A 272-377 order
       Region 6byb A 378-380 disorder
       Region 6byb A 381-403 order
       Region 6byb A 404-407 disorder
       Region 6byb A 408-522 order
Seq 268-590 Hetero dimer :
 Evidence X-RAY 2pqw A Reference
       Region 2pqw A 268-273 disorder
       Region 2pqw A 274-588 order
       Region 2pqw A 589-590 disorder
Seq 268-598 Hetero pentamer :
 Evidence X-RAY 2rjf A Reference
       Region 2rjf A 268-273 disorder
       Region 2rjf A 274-588 order
       Region 2rjf A 589-598 disorder
 Evidence X-RAY 2rjf C Reference
       Region 2rjf C 268-273 disorder
       Region 2rjf C 274-588 order
       Region 2rjf C 589-598 disorder
 Evidence X-RAY 2rjf E Reference
       Region 2rjf E 268-273 disorder
       Region 2rjf E 274-588 order
       Region 2rjf E 589-598 disorder
Seq 268-598 Hetero pentamer : IID00058Complex
 Evidence X-RAY 2rje A Reference
       Region 2rje A 268-273 disorder
       Region 2rje A 274-377 order
       Region 2rje A 378-381 disorder
       Region 2rje A 382-586 order
       Region 2rje A 587-598 disorder
 Evidence X-RAY 2rje B Reference
       Region 2rje B 268-273 disorder
       Region 2rje B 274-586 order
       Region 2rje B 587-598 disorder
 Evidence X-RAY 2rje C Reference
       Region 2rje C 268-273 disorder
       Region 2rje C 274-377 order
       Region 2rje C 378-381 disorder
       Region 2rje C 382-485 order
       Region 2rje C 486-486 disorder
       Region 2rje C 487-590 order
       Region 2rje C 591-598 disorder
Seqphosphorylation
    117-117 Phosphoserine
 
Prediction
NeProc
Disorder 1-75,112-176,188-261,589-724
Order 76-111,177-187,262-297,303-403,410-588,725-840
ProS 1-8,14-44,49-53,59-66,121-130,162-176,188-195,206-211,232-261,601-606,615-638,643-654,708-714
AlphaFold
Disorder 1-272,589-620,652-741,776-840
Order 273-588,621-651,742-775
Pfam Hmmer
PF02820 310-383 6.5e-47
PF02820 417-490 2.1e-39
PF02820 521-594 4.8e-37
PF01530 619-649 7e-16
SEG 129-145 ,149-164 ,223-242
Function
Function in SwissProt
Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.