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IID00336
 UniprotQ9Y6K1
ProteinDNA (cytosine-5)-methyltransferase 3A
GeneDNMT3A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
912
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 40-53 Hetero dimer : IID00392Complex
 Evidence X-RAY 3svm P Reference
       Region 3svm P 40-50 order
       Region 3svm P 51-53 disorder
Seq 275-427 Monomer :
 Evidence X-RAY 3llr A Reference
       Region 3llr A 275-282 disorder
       Region 3llr A 283-385 order
       Region 3llr A 386-397 disorder
       Region 3llr A 398-425 order
       Region 3llr A 426-427 disorder
 Evidence X-RAY 3llr B Reference
       Region 3llr B 275-281 disorder
       Region 3llr B 282-385 order
       Region 3llr B 386-397 disorder
       Region 3llr B 398-425 order
       Region 3llr B 426-427 disorder
 Evidence X-RAY 3llr C Reference
       Region 3llr C 275-282 disorder
       Region 3llr C 283-384 order
       Region 3llr C 385-396 disorder
       Region 3llr C 397-425 order
       Region 3llr C 426-427 disorder
 Evidence X-RAY 3llr D Reference
       Region 3llr D 275-282 disorder
       Region 3llr D 283-425 order
       Region 3llr D 426-427 disorder
 Evidence X-RAY 3llr E Reference
       Region 3llr E 275-282 disorder
       Region 3llr E 283-385 order
       Region 3llr E 386-395 disorder
       Region 3llr E 396-425 order
       Region 3llr E 426-427 disorder
Seq 455-912 Hetero dimer : Q9UJW3
 Evidence X-RAY 4u7p A Reference
       Region 4u7p A 455-473 disorder
       Region 4u7p A 474-832 order
       Region 4u7p A 833-845 disorder
       Region 4u7p A 846-912 order
Seq 476-611 Hetero dimer : IID00062Complex
 Evidence X-RAY 4qbr A Reference
       Region 4qbr A 476-610 order
       Region 4qbr A 611-611 disorder
 Evidence X-RAY 4qbr C Reference
       Region 4qbr C 476-610 order
       Region 4qbr C 611-611 disorder
 Evidence X-RAY 4qbs A Reference
       Region 4qbs A 476-611 order
Seq 476-614 Monomer : IID00062Complex
 Evidence X-RAY 3a1b A Reference
       Region 3a1b A 476-610 order
       Region 3a1b A 611-614 disorder
Seq 476-614 Monomer :
 Evidence X-RAY 3a1a A Reference
       Region 3a1a A 476-576 order
       Region 3a1a A 577-580 disorder
       Region 3a1a A 581-609 order
       Region 3a1a A 610-614 disorder
Seq 476-912 Hetero hexamer : IID00239Complex,Q9UJW3
 Evidence X-RAY 4u7t C Reference
       Region 4u7t C 476-610 order
       Region 4u7t C 611-619 disorder
       Region 4u7t C 620-833 order
       Region 4u7t C 834-845 disorder
       Region 4u7t C 846-912 order
 Evidence X-RAY 4u7t A Reference
       Region 4u7t A 476-610 order
       Region 4u7t A 611-620 disorder
       Region 4u7t A 621-833 order
       Region 4u7t A 834-845 disorder
       Region 4u7t A 846-912 order
Seq 479-610 Hetero trimer : IID00062Complex
 Evidence X-RAY 4qbq C Reference
       Region 4qbq C 479-610 order
 Evidence X-RAY 4qbq A Reference
       Region 4qbq A 479-610 order
Seq 627-912 Hetero tetramer : Q9UJW3
 Evidence X-RAY 2qrv D Reference
       Region 2qrv D 627-629 disorder
       Region 2qrv D 630-831 order
       Region 2qrv D 832-847 disorder
       Region 2qrv D 848-912 order
 Evidence X-RAY 2qrv A Reference
       Region 2qrv A 627-831 order
       Region 2qrv A 832-845 disorder
       Region 2qrv A 846-912 order
 Evidence X-RAY 2qrv H Reference
       Region 2qrv H 627-629 disorder
       Region 2qrv H 630-831 order
       Region 2qrv H 832-847 disorder
       Region 2qrv H 848-912 order
 Evidence X-RAY 2qrv E Reference
       Region 2qrv E 627-831 order
       Region 2qrv E 832-847 disorder
       Region 2qrv E 848-912 order
 Evidence X-RAY 5yx2 D Reference
       Region 5yx2 D 628-912 order
 Evidence X-RAY 5yx2 A Reference
       Region 5yx2 A 628-912 order
 Evidence X-RAY 6brr D Reference
       Region 6brr D 628-912 order
 Evidence X-RAY 6brr A Reference
       Region 6brr A 628-912 order
 Evidence X-RAY 6f57 D Reference
       Region 6f57 D 628-629 disorder
       Region 6f57 D 630-912 order
 Evidence X-RAY 6f57 A Reference
       Region 6f57 A 628-912 order
Seqphosphorylation
    105-105 Phosphoserine
    124-124 Phosphothreonine
    243-243 Phosphoserine
    255-255 Phosphoserine
    261-261 Phosphothreonine
    267-267 Phosphoserine
    390-390 Phosphoserine
    393-393 Phosphoserine
 
Prediction
NeProc
Disorder 1-282,392-401,426-471
Order 283-391,402-425,472-912
ProS 8-12,18-25,40-47,56-65,73-80,87-95,135-143,167-181,187-199,204-220,240-244,250-254,269-274,392-401,426-471
AlphaFold
Disorder 1-203,206-206,221-282,386-398,431-473,611-615
Order 204-205,207-220,283-385,399-430,474-610,616-912
Pfam Hmmer
PF00855 289-362 4.3e-34
PF00145 634-907 3.9e-08
SEG 18-41 ,102-128 ,164-181 ,208-219 ,416-434 ,442-457
Function
Function in SwissProt
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:12138111, PubMed:16357870, PubMed:30478443). DNA methylation is coordinated with methylation of histones (PubMed:12138111, PubMed:16357870, PubMed:30478443). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:12138111, PubMed:16357870, PubMed:30478443). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity). Plays a role in paternal and maternal imprinting (By similarity). Required for methylation of most imprinted loci in germ cells (By similarity). Acts as a transcriptional corepressor for ZBTB18 (By similarity). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity). Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity).