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IID00337
 UniprotP43487
ProteinRan-specific GTPase-activating protein
GeneRANBP1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
201
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-201 Hetero trimer : IID00162Complex
 Evidence X-RAY 1k5g K Reference
       Region 1k5g K 1-21 disorder
       Region 1k5g K 22-167 order
       Region 1k5g K 168-201 disorder
 Evidence X-RAY 1k5g H Reference
       Region 1k5g H 1-21 disorder
       Region 1k5g H 22-167 order
       Region 1k5g H 168-201 disorder
 Evidence X-RAY 1k5g E Reference
       Region 1k5g E 1-21 disorder
       Region 1k5g E 22-167 order
       Region 1k5g E 168-201 disorder
 Evidence X-RAY 1k5g B Reference
       Region 1k5g B 1-21 disorder
       Region 1k5g B 22-167 order
       Region 1k5g B 168-201 disorder
 Evidence X-RAY 1k5d K Reference
       Region 1k5d K 1-21 disorder
       Region 1k5d K 22-167 order
       Region 1k5d K 168-201 disorder
 Evidence X-RAY 1k5d H Reference
       Region 1k5d H 1-21 disorder
       Region 1k5d H 22-167 order
       Region 1k5d H 168-201 disorder
 Evidence X-RAY 1k5d E Reference
       Region 1k5d E 1-21 disorder
       Region 1k5d E 22-167 order
       Region 1k5d E 168-201 disorder
 Evidence X-RAY 1k5d B Reference
       Region 1k5d B 1-21 disorder
       Region 1k5d B 22-167 order
       Region 1k5d B 168-201 disorder
Seqphosphorylation
    18-18 Phosphothreonine
    60-60 Phosphoserine
    21-21 Phosphoserine
    188-188 Phosphoserine
    13-13 Phosphothreonine
Seqacetylation
    183-183 N6-acetyllysine
    150-150 N6-acetyllysine; alternate
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-23
Order 24-201
AlphaFold
Disorder 1-22,170-179,187-201
Order 23-169,180-186
Pfam Hmmer
PF00638 37-161 1.6e-89
SEG 35-47 ,154-168
Function
Function in SwissProt
Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (PubMed:17671426). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:7882974). Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (PubMed:7882974, PubMed:7616957).