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IID00338
 UniprotP08476
ProteinInhibin beta A chain
GeneINHBA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
426
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 30-258,283-305,311-426 Hetero tetramer :
 Evidence X-RAY 5hlz H Reference
       Region 5hlz H 311-356 order
       Region 5hlz H 357-388 disorder
       Region 5hlz H 389-426 order
 Evidence X-RAY 5hlz F Reference
       Region 5hlz F 311-356 order
       Region 5hlz F 357-386 disorder
       Region 5hlz F 387-426 order
 Evidence X-RAY 5hlz D Reference
       Region 5hlz D 311-354 order
       Region 5hlz D 355-388 disorder
       Region 5hlz D 389-426 order
 Evidence X-RAY 5hlz B Reference
       Region 5hlz B 311-356 order
       Region 5hlz B 357-386 disorder
       Region 5hlz B 387-426 order
 Evidence X-RAY 5hlz G Reference
       Region 5hlz G 30-50 disorder
       Region 5hlz G 51-180 order
       Region 5hlz G 181-201 disorder
       Region 5hlz G 202-258 order
       Region 5hlz G 283-299 order
       Region 5hlz G 300-305 disorder
 Evidence X-RAY 5hlz E Reference
       Region 5hlz E 30-50 disorder
       Region 5hlz E 51-180 order
       Region 5hlz E 181-201 disorder
       Region 5hlz E 202-258 order
       Region 5hlz E 283-299 order
       Region 5hlz E 300-305 disorder
 Evidence X-RAY 5hlz C Reference
       Region 5hlz C 30-50 disorder
       Region 5hlz C 51-180 order
       Region 5hlz C 181-201 disorder
       Region 5hlz C 202-258 order
       Region 5hlz C 283-299 order
       Region 5hlz C 300-305 disorder
 Evidence X-RAY 5hlz A Reference
       Region 5hlz A 30-50 disorder
       Region 5hlz A 51-180 order
       Region 5hlz A 181-201 disorder
       Region 5hlz A 202-258 order
       Region 5hlz A 283-299 order
       Region 5hlz A 300-305 disorder
Seq 30-258,283-426 Homo dimer :
 Evidence X-RAY 5hly A Reference
       Region 5hly A 30-50 disorder
       Region 5hly A 51-181 order
       Region 5hly A 182-199 disorder
       Region 5hly A 200-258 order
       Region 5hly A 283-300 order
       Region 5hly A 301-310 disorder
       Region 5hly A 311-359 order
       Region 5hly A 360-384 disorder
       Region 5hly A 385-426 order
Seq 311-426 Hetero tetramer : IID50202Complex
 Evidence X-RAY 2arp A Reference
       Region 2arp A 311-316 order
       Region 2arp A 317-318 disorder
       Region 2arp A 319-355 order
       Region 2arp A 356-364 disorder
       Region 2arp A 365-426 order
Seq 311-426 Hetero tetramer : IID50131Complex
 Evidence X-RAY 1s4y D Reference
       Region 1s4y D 311-313 disorder
       Region 1s4y D 314-359 order
       Region 1s4y D 360-367 disorder
       Region 1s4y D 368-380 order
       Region 1s4y D 381-389 disorder
       Region 1s4y D 390-426 order
 Evidence X-RAY 1s4y B Reference
       Region 1s4y B 311-315 order
       Region 1s4y B 316-317 disorder
       Region 1s4y B 318-379 order
       Region 1s4y B 380-382 disorder
       Region 1s4y B 383-426 order
Seq 311-426 Hetero tetramer : IID00339Complex
 Evidence X-RAY 2b0u B Reference
       Region 2b0u B 311-426 order
 Evidence X-RAY 2b0u A Reference
       Region 2b0u A 311-426 order
Seq 311-426 Hetero tetramer : IID50130Complex
 Evidence X-RAY 1nyu D Reference
       Region 1nyu D 311-320 disorder
       Region 1nyu D 321-324 order
       Region 1nyu D 325-325 disorder
       Region 1nyu D 326-329 order
       Region 1nyu D 330-338 disorder
       Region 1nyu D 339-346 order
       Region 1nyu D 347-347 disorder
       Region 1nyu D 348-355 order
       Region 1nyu D 356-389 disorder
       Region 1nyu D 390-407 order
       Region 1nyu D 408-409 disorder
       Region 1nyu D 410-426 order
 Evidence X-RAY 1nyu B Reference
       Region 1nyu B 311-311 disorder
       Region 1nyu B 312-318 order
       Region 1nyu B 319-319 disorder
       Region 1nyu B 320-358 order
       Region 1nyu B 359-386 disorder
       Region 1nyu B 387-426 order
 Evidence X-RAY 1nys D Reference
       Region 1nys D 311-319 disorder
       Region 1nys D 320-333 order
       Region 1nys D 334-334 disorder
       Region 1nys D 335-350 order
       Region 1nys D 351-351 disorder
       Region 1nys D 352-356 order
       Region 1nys D 357-386 disorder
       Region 1nys D 387-426 order
 Evidence X-RAY 1nys B Reference
       Region 1nys B 311-311 disorder
       Region 1nys B 312-316 order
       Region 1nys B 317-318 disorder
       Region 1nys B 319-358 order
       Region 1nys B 359-386 disorder
       Region 1nys B 387-426 order
Seq 311-426 Homo dimer :
 Evidence X-RAY 2arv B Reference
       Region 2arv B 311-356 order
       Region 2arv B 357-366 disorder
       Region 2arv B 367-426 order
 Evidence X-RAY 2arv A Reference
       Region 2arv A 311-426 order
Seq 311-426 Hetero tetramer : IID00192Complex
 Evidence X-RAY 3b4v F Reference
       Region 3b4v F 311-314 order
       Region 3b4v F 315-315 disorder
       Region 3b4v F 316-316 order
       Region 3b4v F 317-317 disorder
       Region 3b4v F 318-426 order
 Evidence X-RAY 3b4v E Reference
       Region 3b4v E 311-315 order
       Region 3b4v E 316-318 disorder
       Region 3b4v E 319-358 order
       Region 3b4v E 359-364 disorder
       Region 3b4v E 365-426 order
 Evidence X-RAY 3b4v B Reference
       Region 3b4v B 311-314 order
       Region 3b4v B 315-315 disorder
       Region 3b4v B 316-361 order
       Region 3b4v B 362-362 disorder
       Region 3b4v B 363-426 order
 Evidence X-RAY 3b4v A Reference
       Region 3b4v A 311-315 order
       Region 3b4v A 316-316 disorder
       Region 3b4v A 317-358 order
       Region 3b4v A 359-364 disorder
       Region 3b4v A 365-426 order
Seq 311-426 Hetero pentamer : IID00339Complex
 Evidence X-RAY 2p6a A Reference
       Region 2p6a A 311-426 order
 Evidence X-RAY 2p6a B Reference
       Region 2p6a B 311-426 order
Seq 338-355,390-426 Homo dimer : IID00354Complex
 Evidence X-RAY 4mid A This region is the chimera protein. Reference
       Region 4mid A 338-355 order
       Region 4mid A 390-426 order
SeqProS verified 359-379,383-386 Hetero tetramer : IID50131Complex
       Region 1s4y B 318-379 order
       Region 1s4y B 383-426 order
       Region 1nyu B 359-386 disorder
SeqProS verified 359-386 This region is ordered when interacts with another chain of this protein. Homo dimer :
       Region 2arv A 311-426 order
       Region 1nyu B 359-386 disorder
 
Prediction
NeProc
Disorder 1-51,87-91,98-130,258-316
Order 52-86,92-97,131-257,317-426
ProS 6-19,33-45,87-91,98-130,258-262,269-276,284-301,309-316
AlphaFold
Disorder 1-50,144-144,181-200,258-285,300-311,356-371,373-378,380-387
Order 51-143,145-180,201-257,286-299,312-355,372-372,379-379,388-426
Pfam Hmmer
PF00688 42-274 8.4e-56
PF00019 318-426 4.2e-63
SEG 258-286
Function
Function in SwissProt
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.