Search Keyword:


Search option:


IID00341
 UniprotP06730
ProteinEukaryotic translation initiation factor 4E
GeneEIF4E
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
217
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-217 Hetero dimer : Q04637
 Evidence X-RAY 5ei3 A Reference
       Region 5ei3 A 1-26 disorder
       Region 5ei3 A 27-217 order
 Evidence X-RAY 5eir A Reference
       Region 5eir A 1-27 disorder
       Region 5eir A 28-205 order
       Region 5eir A 206-210 disorder
       Region 5eir A 211-217 order
 Evidence X-RAY 5ehc A Reference
       Region 5ehc A 1-26 disorder
       Region 5ehc A 27-204 order
       Region 5ehc A 205-209 disorder
       Region 5ehc A 210-217 order
 Evidence X-RAY 4aza C Reference
       Region 4aza C 1-26 disorder
       Region 4aza C 27-206 order
       Region 4aza C 207-211 disorder
       Region 4aza C 212-217 order
 Evidence X-RAY 4aza A Reference
       Region 4aza A 1-26 disorder
       Region 4aza A 27-208 order
       Region 4aza A 209-211 disorder
       Region 4aza A 212-217 order
Seq 1-217 Hetero tetramer : Q04637
 Evidence X-RAY 2w97 B Reference
       Region 2w97 B 1-29 disorder
       Region 2w97 B 30-50 order
       Region 2w97 B 51-58 disorder
       Region 2w97 B 59-206 order
       Region 2w97 B 207-209 disorder
       Region 2w97 B 210-217 order
 Evidence X-RAY 2w97 A Reference
       Region 2w97 A 1-30 disorder
       Region 2w97 A 31-217 order
Seq 1-217 Monomer :
 Evidence NMR 2gpq A Reference
       Region 2gpq A 1-217 order
       Region 2gpq A 1-35 high_rmsd
       Region 2gpq A 52-57 high_rmsd
       Region 2gpq A 190-190 high_rmsd
       Region 2gpq A 204-211 high_rmsd
 Evidence X-RAY 4tqc B Reference
       Region 4tqc B 28-34 disorder
       Region 4tqc B 35-207 order
       Region 4tqc B 208-211 disorder
       Region 4tqc B 212-217 order
 Evidence X-RAY 4tqc A Reference
       Region 4tqc A 28-34 disorder
       Region 4tqc A 35-82 order
       Region 4tqc A 83-85 disorder
       Region 4tqc A 86-207 order
       Region 4tqc A 208-211 disorder
       Region 4tqc A 212-217 order
 Evidence X-RAY 4tqb B Reference
       Region 4tqb B 28-34 disorder
       Region 4tqb B 35-217 order
 Evidence X-RAY 4tqb A Reference
       Region 4tqb A 28-32 disorder
       Region 4tqb A 33-217 order
 Evidence X-RAY 4tpw B Reference
       Region 4tpw B 28-34 disorder
       Region 4tpw B 35-217 order
 Evidence X-RAY 4tpw A Reference
       Region 4tpw A 28-32 disorder
       Region 4tpw A 33-217 order
 Evidence X-RAY 1ipc A Reference
       Region 1ipc A 1-26 disorder
       Region 1ipc A 27-205 order
       Region 1ipc A 206-210 disorder
       Region 1ipc A 211-217 order
 Evidence X-RAY 1ipb A Reference
       Region 1ipb A 1-26 disorder
       Region 1ipb A 27-217 order
 Evidence X-RAY 5gw6 A Reference
       Region 5gw6 A 23-31 disorder
       Region 5gw6 A 32-206 order
       Region 5gw6 A 207-210 disorder
       Region 5gw6 A 211-217 order
 Evidence X-RAY 4dum A Reference
       Region 4dum A 1-26 disorder
       Region 4dum A 27-207 order
       Region 4dum A 208-211 disorder
       Region 4dum A 212-217 order
 Evidence X-RAY 4dt6 A Reference
       Region 4dt6 A 1-26 disorder
       Region 4dt6 A 27-207 order
       Region 4dt6 A 208-211 disorder
       Region 4dt6 A 212-217 order
 Evidence X-RAY 4bea A Reference
       Region 4bea A 1-30 disorder
       Region 4bea A 31-205 order
       Region 4bea A 206-211 disorder
       Region 4bea A 212-217 order
Seq 1-217 Hetero dimer : Q04637
 Evidence X-RAY 5t46 C Reference
       Region 5t46 C 1-29 disorder
       Region 5t46 C 30-206 order
       Region 5t46 C 207-217 disorder
 Evidence X-RAY 5t46 A Reference
       Region 5t46 A 1-30 disorder
       Region 5t46 A 31-206 order
       Region 5t46 A 207-217 disorder
Seq 1-217 Homo tetramer :
 Evidence X-RAY 3tf2 A Reference
       Region 3tf2 A 1-34 disorder
       Region 3tf2 A 35-203 order
       Region 3tf2 A 204-209 disorder
       Region 3tf2 A 210-217 order
 Evidence X-RAY 3tf2 B Reference
       Region 3tf2 B 1-34 disorder
       Region 3tf2 B 35-50 order
       Region 3tf2 B 51-53 disorder
       Region 3tf2 B 54-205 order
       Region 3tf2 B 206-209 disorder
       Region 3tf2 B 210-217 order
 Evidence X-RAY 3tf2 C Reference
       Region 3tf2 C 1-32 disorder
       Region 3tf2 C 33-118 order
       Region 3tf2 C 119-122 disorder
       Region 3tf2 C 123-205 order
       Region 3tf2 C 206-211 disorder
       Region 3tf2 C 212-217 order
 Evidence X-RAY 3tf2 D Reference
       Region 3tf2 D 1-34 disorder
       Region 3tf2 D 35-117 order
       Region 3tf2 D 118-124 disorder
       Region 3tf2 D 125-203 order
       Region 3tf2 D 204-211 disorder
       Region 3tf2 D 212-217 order
Seq 1-217 Hetero dimer : IID00170Complex
 Evidence X-RAY 1wkw A Reference
       Region 1wkw A 27-217 order
 Evidence X-RAY 2v8y E Reference
       Region 2v8y E 1-33 disorder
       Region 2v8y E 34-203 order
       Region 2v8y E 204-208 disorder
       Region 2v8y E 209-217 order
 Evidence X-RAY 2v8y A Reference
       Region 2v8y A 1-31 disorder
       Region 2v8y A 32-205 order
       Region 2v8y A 206-210 disorder
       Region 2v8y A 211-217 order
 Evidence X-RAY 2v8x E Reference
       Region 2v8x E 1-33 disorder
       Region 2v8x E 34-203 order
       Region 2v8x E 204-208 disorder
       Region 2v8x E 209-217 order
 Evidence X-RAY 2v8x A Reference
       Region 2v8x A 1-31 disorder
       Region 2v8x A 32-205 order
       Region 2v8x A 206-210 disorder
       Region 2v8x A 211-217 order
 Evidence X-RAY 2v8w E Reference
       Region 2v8w E 1-33 disorder
       Region 2v8w E 34-203 order
       Region 2v8w E 204-208 disorder
       Region 2v8w E 209-217 order
 Evidence X-RAY 2v8w A Reference
       Region 2v8w A 1-31 disorder
       Region 2v8w A 32-205 order
       Region 2v8w A 206-210 disorder
       Region 2v8w A 211-217 order
 Evidence X-RAY 3u7x B Reference
       Region 3u7x B 1-30 disorder
       Region 3u7x B 31-217 order
 Evidence X-RAY 3u7x A Reference
       Region 3u7x A 1-30 disorder
       Region 3u7x A 31-217 order
 Evidence X-RAY 5ekv C Reference
       Region 5ekv C 1-35 disorder
       Region 5ekv C 36-204 order
       Region 5ekv C 205-212 disorder
       Region 5ekv C 213-217 order
 Evidence X-RAY 5ekv A Reference
       Region 5ekv A 1-30 disorder
       Region 5ekv A 31-205 order
       Region 5ekv A 206-210 disorder
       Region 5ekv A 211-217 order
Seq 27-217 Hetero dimer : IID00564Complex
 Evidence X-RAY 3am7 A Reference
       Region 3am7 A 27-59 order
       Region 3am7 A 60-60 disorder
       Region 3am7 A 61-217 order
Seq 36-217 Hetero dimer : IID00170Complex
 Evidence X-RAY 4ued A Reference
       Region 4ued A 36-204 order
       Region 4ued A 205-211 disorder
       Region 4ued A 212-217 order
Seqphosphorylation
    22-22 Phosphothreonine
    209-209 Phosphoserine; by PKC and MKNK2
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-32,208-212
Order 33-207,213-217
ProS 208-212
AlphaFold
Disorder 1-28,207-207
Order 29-206,208-217
Pfam Hmmer
PF01652 2-217 3.2e-138
SEG 5-23
Function
Function in SwissProt
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:16271312, PubMed:22578813). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:24335285). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (By similarity). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (PubMed:24335285). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity).